Other Characterized Proteins Similar to ech

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to ech

Finding the characterized proteins for ech ((S)-3-hydroxybutanoyl-CoA hydro-lyase) in 4-hydroxybenzoate catabolism

Or see clustering for step ech

Or see all steps for 4-hydroxybenzoate catabolism

Or cluster curated proteins matching a keyword

Definition of ech

Curated proteins or TIGRFams with EC 4.2.1.150
Ignore hits to Q97MS7 when looking for 'other' hits (short-chain-enoyl-CoA hydratase (EC 4.2.1.150))
Curated sequence BPHYT_RS17335: trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17)
Curated sequence GFF2389: Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17)
Ignore hits to items matching 4.2.1.17 when looking for 'other' hits
Comment: Psest_2437 (GFF2389) is the enoyl-CoA hydrotase for both isoleucine and valine degradation, which implies that (S)-3-hydroxybutanoyl-CoA is a substrate. Q97MS7 is misannotated in BRENDA. BPHYT_RS17335 was misannotated as paaF; it is very similar to the ech H16_A3307, which is a different explanation for its role in phenylacetate utilization. Short-chain enoyl-CoA hydratases are sometimes given EC 4.2.1.17 instead, so those are ignored.

Fetched 8 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 21 other characterized sequences. (Found 29 hits including self hits.)

Removing ignored items reduces this to 11 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for ech.)

CDYL_RAT / Q6AYK9 Chromodomain Y-like protein; CDY-like; Crotonyl-CoA hydratase; Putative tubulin acetyltransferase Cdyl; EC 4.2.1.-; EC 2.3.1.- from Rattus norvegicus (Rat)
PFams: Chromo, ECH_1, ECH_2
589 amino acids: PaperBLAST, CDD, SwissProt::Q6AYK9
93% identical to

CDYL_MOUSE / Q9WTK2 Chromodomain Y-like protein; CDY-like; Crotonyl-CoA hydratase; Putative histone acetyltransferase Cdyl; EC 4.2.1.-; EC 2.3.1.48 from Mus musculus (Mouse)
Q9WTK2 short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Mus musculus
PFams: Chromo, ECH_1, ECH_2
593 amino acids: PaperBLAST, CDD

O07453 BadK from Rhodopseudomonas palustris
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD, metacyc::MONOMER-943
64% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

C8YX87 AcuK from Halomonas sp. HTNK1
PFams: ECH_1, ECH_2
253 amino acids: PaperBLAST, CDD, metacyc::MONOMER-15200
60% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

CDY1_HUMAN / Q9Y6F8 Testis-specific chromodomain protein Y 1; EC 2.3.1.48 from Homo sapiens (Human)
PFams: Chromo, ECH_1, ECH_2
540 amino acids: PaperBLAST, CDD, SwissProt::Q9Y6F8
63% identical to

CDYL_HUMAN / Q9Y232 Chromodomain Y-like protein; CDY-like; Crotonyl-CoA hydratase; EC 4.2.1.- from Homo sapiens (Human)
Q9Y232 short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Homo sapiens
PFams: Chromo, ECH_1, ECH_2
598 amino acids: PaperBLAST, CDD

CH_121974 mitochondrial enoyl-CoA hydratase from Emericella nidulans
PFams: ECH_1, ECH_2
289 amino acids: PaperBLAST, CDD, CharProtDB::CH_121974
52% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
HPCD_METS5 / A4YI89 3-hydroxypropionyl-coenzyme A dehydratase; 3-hydroxypropionyl-CoA dehydratase; EC 4.2.1.116 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD, BRENDA::A4YI89
49% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

CDYL2_HUMAN / Q8N8U2 Chromodomain Y-like protein 2; CDY-like 2 from Homo sapiens (Human)
PFams: Chromo, ECH_1, ECH_2
506 amino acids: PaperBLAST, CDD, SwissProt::Q8N8U2
51% identical to

CDYL2_MOUSE / Q9D5D8 Chromodomain Y-like protein 2; CDY-like 2 from Mus musculus (Mouse)
PFams: Chromo, ECH_1, ECH_2
503 amino acids: PaperBLAST, CDD, SwissProt::Q9D5D8
50% identical to

Q1D5Y4 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Myxococcus xanthus
PFams: ECH_2, ECH_1
258 amino acids: PaperBLAST, CDD, BRENDA::Q1D5Y4
43% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

D3RXI4 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) from Ferroglobus placidus
PFams: 3HCDH_N, NAD_Gly3P_dh_N, NAD_binding_2, F420_oxidored, 3HCDH, 3HCDH, ECH_1, ECH_2
658 amino acids: PaperBLAST, CDD, BRENDA::D3RXI4
42% identical to

A4YDS4 crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.35; EC 4.2.1.150) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YDS4 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Metallosphaera sedula
PFams: 3HCDH_N, NAD_binding_2, 3HCDH, 3HCDH, ECH_1, ECH_2
651 amino acids: PaperBLAST, CDD

A9WEU4 propionyl-CoA synthase subunit (EC 1.3.1.84; EC 4.2.1.116; EC 6.2.1.36) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
PFams: ACAS_N, AMP-binding, AMP-binding_C, ECH_1, ECH_2
1822 amino acids: PaperBLAST, CDD, metacyc::MONOMER-13612
41% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for ech.)

Q58DM8 short chain enoyl-CoA hydratase subunit (EC 4.2.1.17) from Bos taurus
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, metacyc::MONOMER-11697
56% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

ECHM_RAT / P14604 Enoyl-CoA hydratase, mitochondrial; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17 from Rattus norvegicus (Rat)
P14604 enoyl-CoA hydratase (EC 4.2.1.17); DELTA3,5-DELTA2,4-dienoyl-CoA isomerase (EC 5.3.3.21) from Rattus norvegicus
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, BRENDA::P14604
56% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

Q845K2 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas sp. Y2
PFams: ECH_1, ECH_2
257 amino acids: PaperBLAST, CDD, metacyc::MONOMER-15953
55% identical to

Psest_2437 Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) from Pseudomonas stutzeri RCH2
PFams: ECH_1, ECH_2
257 amino acids: PaperBLAST, CDD

P30084 mitochondrial enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens
ECHM_HUMAN / P30084 Enoyl-CoA hydratase, mitochondrial; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17 from Homo sapiens (Human)
P30084 enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens
PFams: ECH_1, ECH_2
290 amino acids: PaperBLAST, CDD, BRENDA::P30084
55% identical to

BPHYT_RS17335 trans-2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD

PAAF_ECOLI / P76082 2,3-dehydroadipyl-CoA hydratase; Enoyl-CoA hydratase; EC 4.2.1.17 from Escherichia coli (strain K12)
P76082 enoyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli
PFams: ECH_1, ECH_2
255 amino acids: PaperBLAST, CDD, BRENDA::P76082
46% identical to

Psest_2437 Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) from Pseudomonas stutzeri RCH2
PFams: ECH_1, ECH_2
257 amino acids: PaperBLAST, CDD

FADB_BACSU / P94549 Probable enoyl-CoA hydratase; EC 4.2.1.17 from Bacillus subtilis (strain 168)
PFams: ECH_1, ECH_2
258 amino acids: PaperBLAST, CDD, SwissProt::P94549
41% identical to

CRCH_SYNWW / Q0AVM1 Crotonyl-CoA hydratase; EC 4.2.1.150 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
PFams: ECH_1, ECH_2
260 amino acids: PaperBLAST, CDD

Shewana3_0024 Enoyl-CoA hydratase (EC 4.2.1.17); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) from Shewanella sp. ANA-3
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
716 amino acids: PaperBLAST, CDD, reanno::ANA3:7022769
43% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

Q9HZJ2 fatty acid oxidation complex α subunit (EC 1.1.1.35; EC 4.2.1.17) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
715 amino acids: PaperBLAST, CDD, metacyc::MONOMER-17591
44% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

ECHP_RAT / P07896 Peroxisomal bifunctional enzyme; PBE; PBFE; EC 4.2.1.17; EC 5.3.3.8; EC 1.1.1.35 from Rattus norvegicus (Rat)
P07896 enoyl-CoA hydratase (EC 4.2.1.17) from Rattus norvegicus
RF|NP_598290.1 noyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH, 3HCDH
722 amino acids: PaperBLAST, CDD, BRENDA::P07896
41% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD

Sama_0032 Enoyl-CoA hydratase (EC 4.2.1.17); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) from Shewanella amazonensis SB2B
PFams: ECH_1, ECH_2, 3HCDH_N, 3HCDH
716 amino acids: PaperBLAST, CDD, reanno::SB2B:6935814
42% identical to

A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: ECH_1, ECH_2
259 amino acids: PaperBLAST, CDD