Other Characterized Proteins Similar to hcl

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to hcl

Finding the characterized proteins for hcl (4-hydroxybenzoyl-CoA ligase) in 4-hydroxybenzoate catabolism

Or see clustering for step hcl

Or see all steps for 4-hydroxybenzoate catabolism

Or cluster curated proteins matching a keyword

Definition of hcl

Curated proteins or TIGRFams with EC 6.2.1.27
Curated sequence Q8GQN9: Benzoate--CoA ligase; Benzoyl-CoA synthetase; EC 6.2.1.25. benzoate-CoA ligase (EC 6.2.1.25). benzoate-CoA ligase (EC 6.2.1.32; EC 6.2.1.25)
Ignore hits to items matching 6.2.1.25 when looking for 'other' hits
Ignore hits to Q8VUF1 when looking for 'other' hits (benzoyl-CoA reductase (EC 1.3.7.8))
Comment: benzoyl-CoA ligases (EC 6.2.1.25) may have this activity as well, i.e. see PMID:12897012 (discussing Q8GQN9). Q8VUF1 (probably a benzoyl-CoA ligase) is misannotated in BRENDA as benzoyl-CoA reductase.

Fetched 4 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 6 other characterized sequences. (Found 10 hits including self hits.)

Removing ignored items reduces this to 1 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for hcl.)

F3Y661 anthranilate-CoA ligase (EC 6.2.1.32) from Stigmatella aurantiaca
PFams: AMP-binding, AMP-binding_C
516 amino acids: PaperBLAST, CDD, metacyc::MONOMER-18342
47% identical to

Q8GQN9 benzoate-CoA ligase (EC 6.2.1.32; EC 6.2.1.25) from Thauera aromatica
BCLA_THAAR / Q8GQN9 Benzoate--CoA ligase; Benzoyl-CoA synthetase; EC 6.2.1.25 from Thauera aromatica
Q8GQN9 benzoate-CoA ligase (EC 6.2.1.25) from Thauera aromatica
PFams: AMP-binding, AMP-binding_C
527 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for hcl.)

Q84HI0 benzoate-CoA ligase subunit (EC 6.2.1.25) from Azoarcus evansii
PFams: AMP-binding, AMP-binding_C
529 amino acids: PaperBLAST, CDD, metacyc::MONOMER-3101
74% identical to

Q8VUF1 benzoyl-CoA reductase (EC 1.3.7.8) from Azoarcus evansii
PFams: AMP-binding, AMP-binding_C
533 amino acids: PaperBLAST, CDD, BRENDA::Q8VUF1
68% identical to

Q59760 benzoate-CoA ligase (EC 6.2.1.25) from Rhodopseudomonas palustris
PFams: AMP-binding, AMP-binding_C
521 amino acids: PaperBLAST, CDD, metacyc::MONOMER-926
52% identical to

Q3LB11 benzoate-CoA ligase (EC 6.2.1.25) from Rhodopseudomonas palustris
PFams: AMP-binding, AMP-binding_C
524 amino acids: PaperBLAST, CDD, BRENDA::Q3LB11
52% identical to

Q39TQ2 benzoate-CoA ligase (EC 6.2.1.25) from Geobacter metallireducens
PFams: AMP-binding, AMP-binding_C
523 amino acids: PaperBLAST, CDD, BRENDA::Q39TQ2
52% identical to