Clusters of Characterized Proteins

Clustering the characterized proteins for ligU (4-oxalomesaconate tautomerase) in 4-hydroxybenzoate catabolism

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Definition of ligU

• Curated proteins or TIGRFams with EC 5.3.2.8
• Curated sequence Q0KJL4: (4E)-oxalomesaconate Delta-isomerase; OMA isomerase; 1,3-allylic isomerase LigU; EC 5.3.3.-
• Comment: This isomerization can occur spontaneously, but the enzyme is probably required for good growth (i.e., fitness data for utilization of 4-vinylphenol or gallic acid). This enzyme is named gllD in MetaCyc. Note that ligU = Q0KJL4 is reported to carry out a different isomerization of 4-oxalomesaconate as part of this pathway. I believe this is just a question of whether to treat the product as the enol form (in UniProt) or the keto form (in MetaCyc).

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 357-361 amino acids (not heteromeric)

LIGU_NOVK1 / Q0KJL4 (4E)-oxalomesaconate Delta-isomerase; OMA isomerase; 1,3-allylic isomerase LigU; EC 5.3.3.- from Novosphingobium sp. (strain KA1) (Sphingomonas sp. (strain KA1))
PFams: PrpF
357 amino acids: PaperBLAST, CDD, Compare to cluster

Q88JY0 4-oxalomesaconate tautomerase (EC 5.3.2.8) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
GALD_PSEPK / Q88JY0 4-oxalomesaconate tautomerase; Gallate degradation protein D; EC 5.3.2.8 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
PFams: PrpF
361 amino acids: PaperBLAST, CDD, Compare to cluster