Other Characterized Proteins Similar to mhpE

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to mhpE

Finding the characterized proteins for mhpE (4-hydroxy-2-oxovalerate aldolase) in 4-hydroxybenzoate catabolism

Or see clustering for step mhpE

Or see all steps for 4-hydroxybenzoate catabolism

Or cluster curated proteins matching a keyword

Definition of mhpE

Curated proteins or TIGRFams with EC 4.1.3.39
Ignore hits to Q2XQZ7 when looking for 'other' hits (4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39))
Comment: Q2XQZ7 is misannotated in BRENDA

Fetched 13 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 3 other characterized sequences. (Found 16 hits including self hits.)

There are also 2 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for mhpE.)

b2245 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli K-12 substr. MG1655
P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli (strain K12)
RHMA_ECOLI / P76469 2-keto-3-deoxy-L-rhamnonate aldolase; KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; EC 4.1.2.53 from Escherichia coli (strain K12)
P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli
PFams: HpcH_HpaI
267 amino acids: PaperBLAST, CDD, BRENDA::P76469
54% identical to

HPCH_ECOLX / Q47098 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase; EC 4.1.2.52 from Escherichia coli
B1IS70 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52) from Escherichia coli
Q47098 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52); 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli
PFams: HpcH_HpaI
262 amino acids: PaperBLAST, CDD

b3126 α-dehydro-β-deoxy-D-glucarate aldolase (EC 4.1.2.20) from Escherichia coli K-12 substr. MG1655
P23522 α-dehydro-β-deoxy-D-glucarate aldolase (EC 4.1.2.20) from Escherichia coli (strain K12)
GARL_ECOLI / P23522 5-keto-4-deoxy-D-glucarate aldolase; KDGluc aldolase; KDGlucA; 2-dehydro-3-deoxy-D-glucarate aldolase; 2-keto-3-deoxy-D-glucarate aldolase; 5-dehydro-4-deoxy-D-glucarate aldolase; Alpha-keto-beta-deoxy-D-glucarate aldolase; EC 4.1.2.20 from Escherichia coli (strain K12)
PFams: HpcH_HpaI, PK
256 amino acids: PaperBLAST, CDD, SwissProt::P23522
48% identical to

KDSGA_PSEPU / P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase; 2-keto-3,6-dideoxy-6-sulfogluconate aldolase; KDSG aldolase; EC 4.1.2.58 from Pseudomonas putida (Arthrobacter siderocapsulatus)
P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase (EC 4.1.2.58) from Pseudomonas putida
PFams: HpcH_HpaI
255 amino acids: PaperBLAST, CDD, SwissProt::P0DOV8
43% identical to

HMM-only sequences

(Since these sequences' annotations are outside the definition for mhpE, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Comamonas testosteroni
PFams: HMGL-like, DmpG_comm
350 amino acids: PaperBLAST, CDD

Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Rhodococcus jostii (strain RHA1)
PFams: HMGL-like, DmpG_comm
339 amino acids: PaperBLAST, CDD