GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for D-LDH (D-lactate dehydrogenase) in D-lactate catabolism

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Definition of D-LDH

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 30 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 322-337 amino acids (not heteromeric)

C0LJH4 D-lactate dehydrogenase (EC 1.1.1.28) from Lactobacillus plantarum subsp. plantarum
Q88VJ2 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, NAD_binding_2
332 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0M3KL04 D-lactate dehydrogenase (EC 1.1.1.28) from Sporolactobacillus inulinus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
335 amino acids: PaperBLAST, CDD, Compare to cluster

A0A140N893 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
329 amino acids: PaperBLAST, CDD, Compare to cluster

F8A9V0 D-lactate dehydrogenase (EC 1.1.1.28) from Thermodesulfatator indicus
PFams: 2-Hacid_dh, 2-Hacid_dh_C
325 amino acids: PaperBLAST, CDD, Compare to cluster

F8RPR8 D-lactate dehydrogenase (EC 1.1.1.28) from Bacillus coagulans
PFams: 2-Hacid_dh, 2-Hacid_dh_C
329 amino acids: PaperBLAST, CDD, Compare to cluster

O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
334 amino acids: PaperBLAST, CDD, Compare to cluster

LDHD_LACDA / P26297 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
P26297 D-lactate dehydrogenase (EC 1.1.1.28) from Lactobacillus delbrueckii subsp. bulgaricus
OMNI|NTL01LD0096 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
PFams: 2-Hacid_dh, 2-Hacid_dh_C, AdoHcyase_NAD, NAD_binding_2
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q1GAA2 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lactobacillus delbrueckii subsp. bulgaricus
PFams: 2-Hacid_dh, 2-Hacid_dh_C
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q48534 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lactobacillus delbrueckii
PFams: 2-Hacid_dh, 2-Hacid_dh_C
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q8RG11 D-lactate dehydrogenase (EC 1.1.1.28) from Fusobacterium nucleatum subsp. nucleatum
PFams: 2-Hacid_dh, 2-Hacid_dh_C, AdoHcyase_NAD, NAD_binding_2
335 amino acids: PaperBLAST, CDD, Compare to cluster

Q9I530 D-lactate dehydrogenase (EC 1.1.1.28) from Pseudomonas aeruginosa
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
329 amino acids: PaperBLAST, CDD, Compare to cluster

CH_091795 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus pentosus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, NAD_binding_2
332 amino acids: PaperBLAST, CDD, Compare to cluster

b1380 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli K-12 substr. MG1655
P52643 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli (strain K12)
CH_091799 D-lactate dehydrogenase; EC 1.1.1.28 from Escherichia coli K12
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
329 amino acids: PaperBLAST, CDD, Compare to cluster

GB|CAA47255.1 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
337 amino acids: PaperBLAST, CDD, Compare to cluster

P51011 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Leuconostoc mesenteroides subsp. cremoris
CH_091801 D-lactate dehydrogenase; EC 1.1.1.28 from Leuconostoc mesenteroides subsp. cremoris
PFams: 2-Hacid_dh, 2-Hacid_dh_C, AlaDh_PNT_C, IlvN, AdoHcyase_NAD
331 amino acids: PaperBLAST, CDD, Compare to cluster

VANH_ENTFC / Q05709 D-specific alpha-keto acid dehydrogenase; Vancomycin resistance protein VanH; EC 1.1.1.- from Enterococcus faecium (Streptococcus faecium)
Q7B609 D-lactate dehydrogenase (EC 1.1.1.28) from Enterococcus faecium
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
322 amino acids: PaperBLAST, CDD, Compare to cluster

LDHD_PEDAC / Q59642 D-lactate/D-glycerate dehydrogenase; D-LDH/GDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28; EC 1.1.1.29 from Pediococcus acidilactici
GI|897794 D-lactate dehydrogenase; EC 1.1.1.28; EC 1.1.1.81 from Pediococcus acidilactici
PFams: 2-Hacid_dh, 2-Hacid_dh_C
331 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 440-587 amino acids (not heteromeric)

A0A0G2K1W9 D-lactate dehydrogenase (EC 1.1.1.28) from Rattus norvegicus
PFams: FAD_binding_4, FAD-oxidase_C
482 amino acids: PaperBLAST, CDD, Compare to cluster

DLD_ARCFU / O29853 D-lactate dehydrogenase (acceptor); EC 1.1.99.6 from Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
O29853 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Archaeoglobus fulgidus
PFams: FAD_binding_4, FAD-oxidase_C
443 amino acids: PaperBLAST, CDD, Compare to cluster

DLD_ARATH / Q94AX4 D-lactate dehydrogenase [cytochrome], mitochondrial; AtD-LDH; D-lactate ferricytochrome C oxidoreductase; Glycolate dehydrogenase; EC 1.1.2.4 from Arabidopsis thaliana (Mouse-ear cress)
Q94AX4 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) from Arabidopsis thaliana
Q94AX4 glycolate dehydrogenase / D-lactate dehydrogenase (EC 1.1.99.14; EC 1.1.2.4) from Arabidopsis thaliana
PFams: FAD_binding_4, FAD-oxidase_C
567 amino acids: PaperBLAST, CDD, Compare to cluster

Q974L0 D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Sulfurisphaera tokodaii
PFams: FAD_binding_4, FAD-oxidase_C
440 amino acids: PaperBLAST, CDD, Compare to cluster

Q9YEU4 D-lactate dehydrogenase (EC 1.1.1.28); D-lactate dehydrogenase (acceptor) (EC 1.1.99.6) from Aeropyrum pernix
PFams: FAD_binding_4, FAD-oxidase_C
473 amino acids: PaperBLAST, CDD, Compare to cluster

W1QLN6 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) from Ogataea angusta
PFams: FAD_binding_4, FAD-oxidase_C
564 amino acids: PaperBLAST, CDD, Compare to cluster

LDHD_DANRE / F1QXM5 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Danio rerio (Zebrafish) (Brachydanio rerio)
PFams: FAD_binding_4, FAD-oxidase_C
497 amino acids: PaperBLAST, CDD, Compare to cluster

DLD1_YEAST / P32891 D-lactate dehydrogenase [cytochrome] 1, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: FAD_binding_4, FAD-oxidase_C
587 amino acids: PaperBLAST, CDD, Compare to cluster

LDHD_MOUSE / Q7TNG8 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Mus musculus (Mouse)
PFams: FAD_binding_4, FAD-oxidase_C
484 amino acids: PaperBLAST, CDD, Compare to cluster

LDHD_HUMAN / Q86WU2 Probable D-lactate dehydrogenase, mitochondrial; DLD; Lactate dehydrogenase D; EC 1.1.2.4 from Homo sapiens (Human)
Q86WU2 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) from Homo sapiens
Q86WU2 mitochondrial D-lactate dehydrogenase (EC 1.1.2.4) from Homo sapiens
PFams: FAD_binding_4, FAD-oxidase_C
507 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 496-530 amino acids (not heteromeric)

DLD3_YEAST / P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P39976 (R)-2-hydroxyglutarate-pyruvate transhydrogenase (EC 1.1.99.40) from Saccharomyces cerevisiae
PFams: FAD_binding_4, FAD-oxidase_C
496 amino acids: PaperBLAST, CDD, Compare to cluster

DLD2_YEAST / P46681 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2HG--pyruvate transhydrogenase DLD2; Actin-interacting protein 2; D-lactate dehydrogenase [cytochrome] 2, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: FAD_binding_4, FAD-oxidase_C
530 amino acids: PaperBLAST, CDD, Compare to cluster

YN53_SCHPO / Q9C1X2 Putative D-lactate dehydrogenase C713.03, mitochondrial; EC 1.1.2.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: FAD_binding_4, FAD-oxidase_C
526 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q8EGS3 Respiratory FAD-dependent D-lactate dehydrogenase Dld; EC=1.1.2.4
934 amino acids: PaperBLAST, CDD