Other Characterized Proteins Similar to dctA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to dctA

Finding the characterized proteins for dctA (organic acid/proton symporter DctA) in acetate catabolism

Or see clustering for step dctA

Or see all steps for acetate catabolism

Or cluster curated proteins matching a keyword

Definition of dctA

Curated sequence Q848I3: Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs
Ignore hits to Q9I4F5 when looking for 'other' hits (C4-dicarboxylate transport protein 2)
Ignore hits to AO356_18980 when looking for 'other' hits (sodium:C4-dicarboxylate symporter (dctA))
Comment: A mutant in P. chlororaphis is reported to be defective in acetate utilization, implying uptake. Fitness data for various strains of P. fluorescens did not indicate this, but uptake could be redundant; for the ortholog in P. aeruginosa (Q9I4F5), acetate does not seem to have been considered as a potential substrate

Fetched 1 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 9 other characterized sequences. (Found 10 hits including self hits.)

Removing ignored items reduces this to 7 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for dctA.)

b3528 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P0A830 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli (strain K12)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12)
GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli
PFams: SDF
428 amino acids: PaperBLAST, CDD, CharProtDB::CH_014038
77% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
PFams: SDF
444 amino acids: PaperBLAST, CDD, TCDB::Q01857
63% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
PFams: SDF
442 amino acids: PaperBLAST, CDD, TCDB::Q1J1H5
61% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis
PFams: SDF
421 amino acids: PaperBLAST, CDD, TCDB::P96603
58% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

b4077 glutamate/aspartate : H⁺ symporter GltP from Escherichia coli K-12 substr. MG1655
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli
PFams: SDF
437 amino acids: PaperBLAST, CDD, SwissProt::P21345
41% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

GLTT_GEOSE / P24943 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Geobacillus stearothermophilus (Bacillus stearothermophilus)
TC 2.A.23.1.2 / P24943 Glutamate/aspartate:Na+ + H+ symporter from Bacillus stearothermophilus
GI|143000 proton/sodium-glutamate symport protein GltT from Geobacillus stearothermophilus
PFams: SDF
421 amino acids: PaperBLAST, CDD, SwissProt::P24943
40% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

GLTT_BACCA / P24944 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus caldotenax
GI|143002 proton/sodium-glutamate symport protein GltT from Bacillus caldotenax
PFams: SDF
421 amino acids: PaperBLAST, CDD, CharProtDB::CH_088342
40% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for dctA.)

AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
PFams: SDF
450 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_18980
91% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD

DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: SDF
436 amino acids: PaperBLAST, CDD, SwissProt::Q9I4F5
81% identical to

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD