Other Characterized Proteins Similar to cycA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to cycA

Finding the characterized proteins for cycA (L-alanine symporter CycA) in L-alanine catabolism

Or see clustering for step cycA

Or see all steps for L-alanine catabolism

Or cluster curated proteins matching a keyword

Definition of cycA

Curated sequence P0AAE0: D-serine/D-alanine/glycine transporter. D-Serine/D-alanine/glycine/D-cycloserine:H+ symporter. D-serine/alanine/glycine/:H⁺symporter. D-serine/alanine/glycine/:H⁺symporter
Curated sequence F2HQ24: Serine transporter, SerP2 or YdgB, of 459 aas and 12 TMSs (Trip et al. 2013). Transports L-alanine (Km = 20 μM), D-alanine (Km = 38 μM), L-serine, D-serine (Km = 356 μM) and glycine (Noens and Lolkema 2015). The encoding gene is adjacent to the one encoding SerP1 (TC# 2.A.3.1.21)
Curated sequence M1IW84: D-serine/L-alanine/D-alanine/glycine/D-cycloserine uptake porter of 556 aas, CycA
Curated sequence Q2VQZ4: Arbuscular mycorrhizal fungal proline:H+ symporter, AAP1 (binds and probably transports nonpolar, hydrophobic amino acids)
Curated sequence GFF1065: L-alanine and D-alanine permease
Curated sequence AO353_16120: D-alanine and L-alanine transporter
Curated sequence AO356_17670: L-alanine and D-alanine permease
Ignore hits to A0A0H2VDI7 when looking for 'other' hits (D-serine/D-alanine/glycine transporter)
Curated sequence A2RI86: DL-alanine permease SerP2
Curated sequence P19145: general amino-acid permease GAP1. General amino-acid permease GAP1. General amino acid permease (all L-amino acids and some D-amino acids as well as β-alanine, polyamines and GABA)
Curated sequence A0A1D8PK89: General amino-acid permease GAP2. General amino and permease and transceptor, GAP2. Transports all amino acids including citruline and eight tested toxic amino acid derivatives
Comment: A sequence nearly identical to E. coli K-12's cycA (CYCA_ECOL6 / A0A0H2VDI7) is annotated as a D-alanine transporter only, ignore. And add DL-alanine permease SERP2_LACLM / A2RI86. And add general amino-acid permease GAP1_YEAST / P19145, GAP2_CANAL / A0A1D8PK89.

Fetched 10 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 35 other characterized sequences. (Found 45 hits including self hits.)

Removing ignored items reduces this to 34 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for cycA.)

SERP1_LACLM / A2RI87 Serine permease SerP1 from Lactococcus lactis subsp. cremoris (strain MG1363)
PFams: AA_permease, AA_permease_2
459 amino acids: PaperBLAST, CDD, SwissProt::A2RI87
62% identical to

TC 2.A.3.1.20 / F2HQ24 Serine transporter, SerP2 or YdgB, of 459 aas and 12 TMSs (Trip et al. 2013). Transports L-alanine (Km = 20 μM), D-alanine (Km = 38 μM), L-serine, D-serine (Km = 356 μM) and glycine (Noens and Lolkema 2015). The encoding gene is adjacent to the one encoding SerP1 (TC# 2.A.3.1.21) from Lactococcus lactis subsp. lactis (strain CV56)
PFams: AA_permease, AA_permease_2
457 amino acids: PaperBLAST, CDD

TC 2.A.3.1.21 / F2HQ25 Serine uptake transporter, SerP1, of 259 aas and 12 TMSs (Trip et al. 2013). L-serine is the highest affinity substrate (Km = 18 μM), but SerP1 also transports L-threonine and L-cysteine (Km values = 20 - 40 μM) from Lactococcus lactis subsp. lactis (strain CV56)
PFams: AA_permease, AA_permease_2
459 amino acids: PaperBLAST, CDD, TCDB::F2HQ25
62% identical to

SERP2_LACLM / A2RI86 DL-alanine permease SerP2 from Lactococcus lactis subsp. cremoris (strain MG1363)
PFams: AA_permease, AA_permease_2
460 amino acids: PaperBLAST, CDD

TC 2.A.3.1.6 / P37460 Proline-specific permease (ProY) from Salmonella typhimurium
PFams: AA_permease_2, Spore_permease, AA_permease
456 amino acids: PaperBLAST, CDD, TCDB::P37460
57% identical to

AO353_16120 D-alanine and L-alanine transporter from Pseudomonas fluorescens FW300-N2E3
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

TC 2.A.3.1.23 / P0AAE2 ProY of 457 aas and 12 TMSs from Escherichia coli (strain K12)
PFams: AA_permease_2, Spore_permease, AA_permease
457 amino acids: PaperBLAST, CDD, TCDB::P0AAE2
55% identical to

PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

AO353_12275 histidine permease from Pseudomonas fluorescens FW300-N2E3
PFams: AA_permease, AA_permease_2
468 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_12275
54% identical to

PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

GAP5_CANAL / A0A1D8PMB1 Amino-acid permease GAP5 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: AA_permease, AA_permease_2
618 amino acids: PaperBLAST, CDD, SwissProt::A0A1D8PMB1
55% identical to

GAP2_CANAL / A0A1D8PK89 General amino-acid permease GAP2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
TC 2.A.3.10.24 / Q59YT0 General amino and permease and transceptor, GAP2. Transports all amino acids including citruline and eight tested toxic amino acid derivatives from Candida albicans
PFams: AA_permease, AA_permease_2
588 amino acids: PaperBLAST, CDD

GAP1_CANAL / Q5AG77 Amino-acid permease GAP1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
TC 2.A.3.10.23 / Q5AG77 Amino acid permease, GAP1. Transports Arg, Met, Leu and Phe from Candida albicans
CH_123668 general amino acid permease from Candida albicans
PFams: AA_permease_2, AA_permease
582 amino acids: PaperBLAST, CDD, SwissProt::Q5AG77
53% identical to

GAP3_CANAL / A0A1D8PN88 Amino-acid permease GAP3 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: AA_permease, AA_permease_2
599 amino acids: PaperBLAST, CDD, SwissProt::A0A1D8PN88
54% identical to

YI26_SCHPO / Q9P768 Uncharacterized amino-acid permease P7G5.06 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
CH_125860 plasma membrane amino acid permease Per1 from Schizosaccharomyces pombe
PFams: AA_permease, AA_permease_2
583 amino acids: PaperBLAST, CDD, CharProtDB::CH_125860
50% identical to

TC 2.A.3.10.22 / Q2VQZ4 Arbuscular mycorrhizal fungal proline:H+ symporter, AAP1 (binds and probably transports nonpolar, hydrophobic amino acids) from Glomus mosseae
PFams: AA_permease, AA_permease_2
536 amino acids: PaperBLAST, CDD

TC 2.A.3.10.26 / Q59NZ6 General amino acid porter, GAP6. Transports almost all amino acids tested except arginine and citruline from Candida albicans
PFams: AA_permease_2, AA_permease
576 amino acids: PaperBLAST, CDD, TCDB::Q59NZ6
48% identical to

GAP1_YEAST / P19145 General amino-acid permease GAP1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.2 / P19145 General amino acid permease (all L-amino acids and some D-amino acids as well as β-alanine, polyamines and GABA) from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_012965.1 general amino-acid permease GAP1 from Saccharomyces cerevisiae
PFams: AA_permease, AA_permease_2
602 amino acids: PaperBLAST, CDD

GAP4_CANAL / Q59WB3 S-adenosylmethionine permease GAP4; SAM permease; Amino-acid permease GAP4 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
TC 2.A.3.10.25 / Q59WB3 Arginine transporter, GAP4 from Candida albicans
CH_123720 potential general amino acid permease from Candida albicans
PFams: AA_permease, AA_permease_2
607 amino acids: PaperBLAST, CDD, SwissProt::Q59WB3
48% identical to

HIP1_YEAST / P06775 Histidine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.1 / P06775 High affinity histidine permease (also implicated in Mn2+ efflux; Co2+, Ni2+, Zn2+ and Cu2+ uptake) from Saccharomyces cerevisiae (Baker's yeast)
GI|1323339 histidine permease from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
603 amino acids: PaperBLAST, CDD, CharProtDB::CH_091109
54% identical to

GAP6_CANAL / A0A1D8PNP3 Amino-acid permease GAP6 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: AA_permease_2, AA_permease
568 amino acids: PaperBLAST, CDD, SwissProt::A0A1D8PNP3
54% identical to

AAT1_SCHPO / Q9P5N2 Amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: AA_permease_2, AA_permease
579 amino acids: PaperBLAST, CDD, SwissProt::Q9P5N2
51% identical to

TC 2.A.3.10.21 / Q9URZ4 The basic amino acid (canavanine sensitivity) transporter, Cat1 from Schizosaccharomyces pombe (Fission yeast)
RF|NP_595008.2 uncharacterized amino-acid permease C869.11 from Schizosaccharomyces pombe
PFams: AA_permease, AA_permease_2
580 amino acids: PaperBLAST, CDD, CharProtDB::CH_091412
49% identical to

CAT1_SCHPO / Q9URZ4 Cationic amino acid transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: AA_permease, AA_permease_2
587 amino acids: PaperBLAST, CDD, SwissProt::Q9URZ4
49% identical to

TC 2.A.3.10.28 / O60170 Probable amino-acid permease Meu22 (Meiotic expression up-regulated protein 22) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
PFams: AA_permease, AA_permease_2
574 amino acids: PaperBLAST, CDD, TCDB::O60170
45% identical to

SAM3_YEAST / Q08986 S-adenosylmethionine permease SAM3; S-adenosylmethionine metabolism protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.15 / Q08986 S-adenosylmethionine uptake permease, SAM3 (also takes up polyamines, glutamate, lysine and the toxic S-adenosylmethionine analogue sinefungin) from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_015049.1 S-adenosylmethionine permease SAM3 from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
587 amino acids: PaperBLAST, CDD, CharProtDB::CH_091257
45% identical to

TAT2_YEAST / P38967 Tryptophan permease; Tryptophan amino acid transporter from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.8 / P38967 Tryptophan permease, Tat2. Regulated via endocytosis by ATP-binding Cassette Transporters, Pdr5 (3.A.1.205.1) and Yor1 (3.A.208.3) as well as a seven-transmembrane protein, RSB1 (9.A.27.1.2) from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_014622.1 tryptophan permease from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
592 amino acids: PaperBLAST, CDD, CharProtDB::CH_091156
47% identical to

GNP1_YEAST / P48813 High-affinity glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.5 / P48813 High affinity glutamine permease from Saccharomyces cerevisiae (Baker's yeast)
GI|927778 high-affinity glutamine permease from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
663 amino acids: PaperBLAST, CDD, CharProtDB::CH_090998
45% identical to

BAP2_YEAST / P38084 Leu/Val/Ile amino-acid permease; Branched-chain amino-acid permease 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: AA_permease, AA_permease_2
609 amino acids: PaperBLAST, CDD, SwissProt::P38084
43% identical to

TC 2.A.3.10.6 / P38084 Leu/Val/Ile amino acid permease from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_009624.1 Leu/Val/Ile amino-acid permease from Saccharomyces cerevisiae
PFams: AA_permease, AA_permease_2
609 amino acids: PaperBLAST, CDD, CharProtDB::CH_091448
43% identical to

RF|NP_595000.1 amino acid permease Isp5 from Schizosaccharomyces pombe
PFams: AA_permease, AA_permease_2
580 amino acids: PaperBLAST, CDD, CharProtDB::CH_125310
46% identical to

AO356_18530 L-tyrosine transporter from Pseudomonas fluorescens FW300-N2C3
PFams: AA_permease, AA_permease_2
471 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_18530
43% identical to

AO356_17670 L-alanine and D-alanine permease from Pseudomonas fluorescens FW300-N2C3
PFams: AA_permease, AA_permease_2
473 amino acids: PaperBLAST, CDD

YHE1_SCHPO / Q9HDV2 Uncharacterized amino-acid permease PB2B2.01 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: AA_permease, AA_permease_2
585 amino acids: PaperBLAST, CDD, SwissProt::Q9HDV2
46% identical to

b0576 phenylalanine:H⁺ symporter PheP from Escherichia coli K-12 substr. MG1655
P24207 phenylalanine:H⁺ symporter PheP from Escherichia coli (strain K12)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli
PFams: AA_permease, AA_permease_2
458 amino acids: PaperBLAST, CDD, TCDB::P24207
44% identical to

AO356_17670 L-alanine and D-alanine permease from Pseudomonas fluorescens FW300-N2C3
PFams: AA_permease, AA_permease_2
473 amino acids: PaperBLAST, CDD

b0112 aromatic amino acid:H⁺ symporter AroP from Escherichia coli K-12 substr. MG1655
P15993 aromatic amino acid:H⁺ symporter AroP from Escherichia coli (strain K12)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli
PFams: AA_permease, AA_permease_2
457 amino acids: PaperBLAST, CDD, TCDB::P15993
44% identical to

PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

MMP1_YEAST / Q12372 S-methylmethionine permease 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.16 / Q12372 S-methylmethionine uptake permease, Mmp1 from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_013039.1 S-methylmethionine permease 1 from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
583 amino acids: PaperBLAST, CDD, CharProtDB::CH_091514
42% identical to

AGP1_YEAST / P25376 General amino acid permease AGP1; Asparagine/glutamine permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.7 / P25376 Asn/Gln permease from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_009905.3 general amino acid permease AGP1 from Saccharomyces cerevisiae
PFams: AA_permease_2, AA_permease
633 amino acids: PaperBLAST, CDD, CharProtDB::CH_091105
42% identical to

TAT1_YEAST / P38085 Valine/tyrosine/tryptophan amino-acid permease 1; Tyrosine and tryptophan amino acid transporter 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.9 / P38085 Val/Tyr/Trp permease from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_009625.1 valine/tyrosine/tryptophan amino-acid permease from Saccharomyces cerevisiae
PFams: AA_permease, AA_permease_2
619 amino acids: PaperBLAST, CDD, CharProtDB::CH_091631
44% identical to

BAP3_YEAST / P41815 Valine amino-acid permease; Branched-chain amino-acid permease 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.3.10.27 / P41815 Valine amino-acid permease (Branched-chain amino-acid permease 3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: AA_permease, AA_permease_2
604 amino acids: PaperBLAST, CDD, SwissProt::P41815
44% identical to

GABP_BACSU / P46349 GABA permease; 4-amino butyrate transport carrier; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis
PFams: Spore_permease, AA_permease_2, AA_permease
469 amino acids: PaperBLAST, CDD, SwissProt::P46349
40% identical to

PS417_05405 L-alanine and D-alanine permease from Pseudomonas simiae WCS417
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

TC 2.A.3.1.8 / P40812 Asparagine permease (AnsP) of 497 aas and 12 TMSs from Salmonella typhimurium
PFams: AA_permease_2, AA_permease
497 amino acids: PaperBLAST, CDD, TCDB::P40812
40% identical to

AO353_16120 D-alanine and L-alanine transporter from Pseudomonas fluorescens FW300-N2E3
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

b1453 L-asparagine transporter from Escherichia coli K-12 substr. MG1655
ANSP_ECOLI / P77610 L-asparagine permease; L-asparagine transport protein from Escherichia coli (strain K12)
TC 2.A.3.1.24 / P77610 Asparagine transporter of 499 aas and 12 TMSs, 91% identical to the orthologue in Salmonella enterica (2.A.3.1.8) from Escherichia coli (strain K12)
PFams: AA_permease_2, AA_permease
499 amino acids: PaperBLAST, CDD, SwissProt::P77610
42% identical to

AO353_16120 D-alanine and L-alanine transporter from Pseudomonas fluorescens FW300-N2E3
PFams: AA_permease, AA_permease_2
472 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for cycA.)

CYCA_ECOL6 / A0A0H2VDI7 D-serine/D-alanine/glycine transporter from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
PFams: AA_permease, AA_permease_2
470 amino acids: PaperBLAST, CDD, SwissProt::A0A0H2VDI7
98% identical to

b4208 D-serine/alanine/glycine/:H⁺symporter from Escherichia coli K-12 substr. MG1655
P0AAE0 D-serine/alanine/glycine/:H⁺symporter from Escherichia coli (strain K12)
CYCA_ECOLI / P0AAE0 D-serine/D-alanine/glycine transporter from Escherichia coli (strain K12)
TC 2.A.3.1.7 / P0AAE0 D-Serine/D-alanine/glycine/D-cycloserine:H+ symporter from Escherichia coli
PFams: AA_permease, AA_permease_2
470 amino acids: PaperBLAST, CDD