Other Characterized Proteins Similar to artM

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to artM

Finding the characterized proteins for artM (L-arginine ABC transporter, permease component 1 (ArtM/HisM/AotM)) in L-arginine catabolism

Or see clustering for step artM

Or see all steps for L-arginine catabolism

Or cluster curated proteins matching a keyword

Definition of artM

Curated sequence P0A2I7: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium
Curated sequence P0AEU3: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1)
Curated sequence O50183: AotP aka AotM aka PA0890, component of Arginine/ornithine (but not lysine) porter
Curated sequence Q9HU29: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
Curated sequence BPHYT_RS07680: ABC transporter for L-Arginine, permease component 1
Curated sequence GFF4243: ABC transporter for L-Arginine, permease component 2
Curated sequence Pf1N1B4_3433: ABC transporter for L-Arginine and L-Citrulline, permease component 2
Curated sequence AO353_03045: ABC transporter for L-Arginine and L-Citrulline, permease component 1
Curated sequence AO356_18710: L-Arginine ABC transporter, permease component 1
Curated sequence Pf6N2E2_5662: L-Arginine ABC transporter, permease protein AotM
Curated sequence P0AE30: Arginine ABC transporter permease protein ArtM. Arginine transport system permease protein ArtM aka B0861, component of Arginine porter. L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1). L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1)
Ignore hits to AO356_09910 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
Ignore hits to Pf6N2E2_2960 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
Ignore hits to AO356_05505 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
Comment: ArtM and HisM are distantly related and were combined. TC 1.B.6.2.7 / F9GZA7 is annotated as ArtM but seems more likely to be an outer membrane porin, so it is not included. Ignore closely related lysine transporters from P. fluorescens (which may well transport arginine; AO356_09910 has a subtle defect in arginine utilization).

Fetched 11 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 5 other characterized sequences. (Found 16 hits including self hits.)

Removing ignored items reduces this to 2 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for artM.)

TC 3.A.1.3.5 / P35114 OCM1 aka OccM, component of Octopine porter from Agrobacterium tumefaciens
PFams: BPD_transp_1
Heteromeric, 245 amino acids: PaperBLAST, CDD, TCDB::P35114
47% identical to

TC 3.A.1.3.11 / O50183 AotP aka AotM aka PA0890, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD

TC 3.A.1.3.6 / P35113 NocM aka ATU6025 aka AGR_PTI_65, component of Nopaline porter from Agrobacterium tumefaciens
PFams: BPD_transp_1
Heteromeric, 241 amino acids: PaperBLAST, CDD, TCDB::P35113
49% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for artM.)

AO356_09910 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
PFams: BPD_transp_1
Heteromeric, 229 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_09910
71% identical to

TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: BPD_transp_1
Heteromeric, 230 amino acids: PaperBLAST, CDD

Pf6N2E2_2960 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2E2
PFams: BPD_transp_1
Heteromeric, 236 amino acids: PaperBLAST, CDD, reanno::pseudo6_N2E2:Pf6N2E2_2960
66% identical to

BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
PFams: BPD_transp_1
Heteromeric, 237 amino acids: PaperBLAST, CDD

AO356_05505 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
PFams: BPD_transp_1
Heteromeric, 236 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_05505
65% identical to

BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
PFams: BPD_transp_1
Heteromeric, 237 amino acids: PaperBLAST, CDD