Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for ans (asparaginase) in L-asparagine catabolism

Or see other characterized proteins similar to ans

Or see all steps for L-asparagine catabolism

Or cluster curated proteins matching a keyword

Definition of ans

Curated proteins or TIGRFams with EC 3.5.1.1
Curated proteins or TIGRFams with EC 3.5.1.38
Do not include HMM TIGR00519 (when considering EC numbers)
Comment: Isoaspartyl peptidases such as E. coli iaaA have this activity and are labeled heteromeric, because the proenzyme is cleaved into two subunits; this need not be represented here. TIGR00519 is not used because it hits GatD, a subunit of glutamyl-tRNA(Gln) amidotransferase

Fetched 44 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 41 of these sequences

Found 6 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 324-381 amino acids (not heteromeric)

B6ZCD8 asparaginase (EC 3.5.1.1) from Helicobacter pylori
I0ZIE0 asparaginase (EC 3.5.1.1) from Helicobacter pylori
PFams: Asparaginase, Asparaginase_C
330 amino acids: PaperBLAST, CDD, Compare to cluster

J9H7D1 asparaginase (EC 3.5.1.1) from Staphylococcus sp.
PFams: Asparaginase, Asparaginase_C
324 amino acids: PaperBLAST, CDD, Compare to cluster

b2957 L-asparaginase 2 (EC 3.5.1.38; EC 3.5.1.1) from Escherichia coli K-12 substr. MG1655
P00805 L-asparaginase 2 (EC 3.5.1.38) from Escherichia coli (strain K12)
ASPG2_ECOLI / P00805 L-asparaginase 2; L-asparaginase II; L-ASNase II; L-asparagine amidohydrolase II; Colaspase; EC 3.5.1.1 from Escherichia coli (strain K12)
P00805 asparaginase (EC 3.5.1.1) from Escherichia coli
PFams: Asparaginase, Asparaginase_C
348 amino acids: PaperBLAST, CDD, Compare to cluster

P38986 asparaginase (EC 3.5.1.1) from Saccharomyces cerevisiae
PFams: Asparaginase, Asparaginase_C
381 amino acids: PaperBLAST, CDD, Compare to cluster

Q66CJ2 asparaginase (EC 3.5.1.1) from Yersinia pseudotuberculosis
PFams: Asparaginase, Asparaginase_C
345 amino acids: PaperBLAST, CDD, Compare to cluster

Q6Q4F3 asparaginase (EC 3.5.1.1) from Dickeya chrysanthemi
PFams: Asparaginase, Asparaginase_C
348 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZLB9 asparaginase (EC 3.5.1.1) from Helicobacter pylori J99
PFams: Asparaginase, Asparaginase_C
332 amino acids: PaperBLAST, CDD, Compare to cluster

PDB|1AGX_A glutaminase-asparaginase; EC 3.5.1.38 from Acinetobacter glutaminasificans
PFams: Asparaginase, Asparaginase_C
331 amino acids: PaperBLAST, CDD, Compare to cluster

ASPG2_BACSU / O34482 L-asparaginase 2; L-ASNase 2; L-asparagine amidohydrolase 2; EC 3.5.1.1 from Bacillus subtilis (strain 168)
PFams: Asparaginase, Asparaginase_C
375 amino acids: PaperBLAST, CDD, Compare to cluster

ASPQ_PSEFA / O68897 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; EC 3.5.1.38 from Pseudomonas fluorescens biotype A
PFams: Asparaginase, Asparaginase_C
362 amino acids: PaperBLAST, CDD, Compare to cluster

ASPG_DICCH / P06608 L-asparaginase; L-ASNase; L-asparagine amidohydrolase; EC 3.5.1.1 from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
PFams: Asparaginase, Asparaginase_C
348 amino acids: PaperBLAST, CDD, Compare to cluster

ASP22_YEAST / P0CX77 L-asparaginase 2-2; L-asparaginase II; L-asparagine amidohydrolase II; ASP II; EC 3.5.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
ASP23_YEAST / P0CX78 L-asparaginase 2-3; L-asparaginase II; L-asparagine amidohydrolase II; ASP II; EC 3.5.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
ASP24_YEAST / P0CX79 L-asparaginase 2-4; L-asparaginase II; L-asparagine amidohydrolase II; ASP II; EC 3.5.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
ASP21_YEAST / P0CZ17 L-asparaginase 2-1; L-asparaginase II; L-asparagine amidohydrolase II; ASP II; EC 3.5.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Asparaginase, Asparaginase_C
362 amino acids: PaperBLAST, CDD, Compare to cluster

ASPQ_PSES7 / P10182 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; PGA; EC 3.5.1.38 from Pseudomonas sp. (strain ATCC 29598 / 7A)
PFams: Asparaginase, Asparaginase_C
337 amino acids: PaperBLAST, CDD, Compare to cluster

Q6Q4F4 L-asparaginase subunit (EC 3.5.1.38) from Pectobacterium atrosepticum
Q6Q4F4 asparaginase (EC 3.5.1.1) from Pectobacterium atrosepticum
PFams: Asparaginase, Asparaginase_C
346 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS08815 L-asparaginase (EC 3.5.1.1) from Burkholderia phytofirmans PsJN
PFams: Asparaginase, Asparaginase_C
347 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 326-339 amino acids (not heteromeric)

b1767 L-asparaginase 1 (EC 3.5.1.38; EC 3.5.1.1) from Escherichia coli K-12 substr. MG1655
P0A962 L-asparaginase 1 (EC 3.5.1.38) from Escherichia coli (strain K12)
ASPG1_ECOLI / P0A962 L-asparaginase 1; L-asparaginase I; L-ASNase I; L-asparagine amidohydrolase I; EC 3.5.1.1 from Escherichia coli (strain K12)
PFams: Asparaginase, Asparaginase_C
338 amino acids: PaperBLAST, CDD, Compare to cluster

Q8TZE8 asparaginase (EC 3.5.1.1) from Pyrococcus furiosus
PFams: Asparaginase, Asparaginase_C
326 amino acids: PaperBLAST, CDD, Compare to cluster

ASPG1_BACSU / P26900 L-asparaginase 1; L-ASNase 1; L-asparagine amidohydrolase 1; EC 3.5.1.1 from Bacillus subtilis (strain 168)
PFams: Asparaginase, Asparaginase_C
329 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS25090 L-asparaginase (EC 3.5.1.1) from Pedobacter sp. GW460-11-11-14-LB5
PFams: Asparaginase, Asparaginase_C
339 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_740 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens GW456-L13
PFams: Asparaginase, Asparaginase_C
334 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_2023 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N1B4
PFams: Asparaginase, Asparaginase_C
334 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_09960 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2E3
PFams: Asparaginase, Asparaginase_C
334 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_11100 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2C3
PFams: Asparaginase, Asparaginase_C
334 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_4087 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2E2
PFams: Asparaginase, Asparaginase_C
334 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 306-333 amino acids (5/7 heteromeric)

IAAA_ECOLI / P37595 Isoaspartyl peptidase; Beta-aspartyl-peptidase; EcAIII; Isoaspartyl dipeptidase; EC 3.4.19.5 from Escherichia coli (strain K12)
P37595 beta-aspartyl-peptidase (EC 3.4.19.5); asparaginase (EC 3.5.1.1) from Escherichia coli
ECOCYC|MONOMER0-3 L-asparaginase from Escherichia coli K12
PFams: Asparaginase_2
Heteromeric, 321 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JHT1 asparaginase (EC 3.5.1.1) from Thermococcus kodakarensis
PFams: Asparaginase_2
306 amino acids: PaperBLAST, CDD, Compare to cluster

Q7L266 isoaspartyl peptidase/L-asparaginase precursor from Homo sapiens
ASGL1_HUMAN / Q7L266 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Homo sapiens (Human)
Q7L266 beta-aspartyl-peptidase (EC 3.4.19.5); asparaginase (EC 3.5.1.1) from Homo sapiens
PFams: Asparaginase_2
Heteromeric, 308 amino acids: PaperBLAST, CDD, Compare to cluster

Q8GXG1 asparaginase (EC 3.5.1.1) from Arabidopsis thaliana
PFams: Asparaginase_2
325 amino acids: PaperBLAST, CDD, Compare to cluster

ASGL1_DANRE / Q5BKW9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Danio rerio (Zebrafish) (Brachydanio rerio)
PFams: Asparaginase_2
Heteromeric, 310 amino acids: PaperBLAST, CDD, Compare to cluster

ASGL1_MOUSE / Q8C0M9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Mus musculus (Mouse)
PFams: Asparaginase_2
Heteromeric, 326 amino acids: PaperBLAST, CDD, Compare to cluster

ASGL1_RAT / Q8VI04 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Asparaginase-like sperm autoantigen; Beta-aspartyl-peptidase; Glial asparaginase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Rattus norvegicus (Rat)
PFams: Asparaginase_2
Heteromeric, 333 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 564-682 amino acids (not heteromeric)

H0W0T5 asparaginase (EC 3.5.1.1) from Cavia porcellus
PFams: Asparaginase, Asparaginase_C, Ank_2, Ank_4, Ank_5, Ank, Ank_3, Ank_4
565 amino acids: PaperBLAST, CDD, Compare to cluster

W0G253 asparaginase (EC 3.5.1.1) from Rhizomucor miehei
PFams: Asparaginase, Asparaginase_C, Ank_4, Ank_2, Ank_5, Ank, Ank_3, Ank_4
682 amino acids: PaperBLAST, CDD, Compare to cluster

LPP60_RAT / O88202 60 kDa lysophospholipase; Lysophospholipase-transacylase; EC 3.1.1.5; EC 3.5.1.1; EC 3.1.1.47 from Rattus norvegicus (Rat)
PFams: Asparaginase, Asparaginase_C, Ank_2, Ank_4, Ank_5, Ank, Ank_3
564 amino acids: PaperBLAST, CDD, Compare to cluster

ASPG_DIRIM / Q9U518 L-asparaginase; DiAsp; L-asparagine amidohydrolase; EC 3.5.1.1 from Dirofilaria immitis (Canine heartworm)
PFams: Asparaginase, Asparaginase_C, Ank_4, Ank_2, Ank_5, Ank_3, Ank_2, Ank_4, Ank, Ank_3
590 amino acids: PaperBLAST, CDD, Compare to cluster

Q86U10 60 kDa lysophospholipase (EC 3.1.1.47; EC 3.5.1.38) from Homo sapiens
PFams: Asparaginase, Asparaginase_C, Ank_2, Ank_4, Ank_5, Ank, Ank_3, Ank_4
573 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 320-371 amino acids (not heteromeric)

Q9RFN5 asparaginase (EC 3.5.1.1) from Rhizobium etli
PFams: Asparaginase_II
371 amino acids: PaperBLAST, CDD, Compare to cluster

W0KM71 asparaginase (EC 3.5.1.1) from Nocardiopsis alba
PFams: Asparaginase_II
320 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_c36210 L-asparaginase (EC 3.5.1.1) from Phaeobacter inhibens BS107
PFams: Asparaginase_II
333 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 308-310 amino acids (not heteromeric)

b1524 glutaminase 2 (EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655
P0A6W0 glutaminase 2 (EC 3.5.1.38) from Escherichia coli (strain K12)
GLSA2_ECOLI / P0A6W0 Glutaminase 2; EC 3.5.1.2 from Escherichia coli (strain K12)
P0A6W0 glutaminase (EC 3.5.1.2) from Escherichia coli
RF|NP_416041 glutaminase 2 from Escherichia coli K12
PFams: Glutaminase
308 amino acids: PaperBLAST, CDD, Compare to cluster

b0485 glutaminase 1 (EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655
P77454 glutaminase 1 (EC 3.5.1.38) from Escherichia coli (strain K12)
GLSA1_ECOLI / P77454 Glutaminase 1; EC 3.5.1.2 from Escherichia coli (strain K12)
P77454 glutaminase (EC 3.5.1.2) from Escherichia coli
MB|P77454 glutaminase 1 from Escherichia coli K12
PFams: Glutaminase
310 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

b0674 asparagine synthetase B (EC 6.3.5.4; EC 6.3.1.1; EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655
P22106 asparagine synthetase B (EC 6.3.5.4; EC 6.3.1.1; EC 3.5.1.38) from Escherichia coli (strain K12)
ASNB_ECOLI / P22106 Asparagine synthetase B [glutamine-hydrolyzing]; AS-B; EC 6.3.5.4 from Escherichia coli (strain K12)
P22106 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Escherichia coli
CH_002444 asparagine synthetase B, glutamine-hydrolyzing; EC 6.3.5.4 from Escherichia coli
PFams: GATase_6, GATase_7, DUF3700, Asn_synthase, Asn_synthase
554 amino acids: PaperBLAST, CDD

ASPQ_DELAC / P83712 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; EC 3.5.1.38 from Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)
33 amino acids: PaperBLAST, CDD

P28492 glutaminase subunit (EC 3.5.1.38) from Rattus norvegicus
PFams: EF-hand_14, Glutaminase, Ank_2, Ank, Ank_3, Ank_4
602 amino acids: PaperBLAST, CDD