Other Characterized Proteins Similar to glt

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to glt

Finding the characterized proteins for glt (aspartate:proton symporter Glt) in L-asparagine catabolism

Or see clustering for step glt

Or see all steps for L-asparagine catabolism

Or cluster curated proteins matching a keyword

Definition of glt

Curated sequence P21345: Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein. Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). glutamate/aspartate : H⁺ symporter GltP
Curated sequence CH_014038: aerobic C4-dicarboxylate transport protein. Aerobic C4-dicarboxylate transport protein. Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase. C4 dicarboxylate/orotate:H⁺ symporter. C4 dicarboxylate/orotate:H⁺ symporter
UniProt sequence A0A0N9WTL5: SubName: Full=Amino acid:proton symporter {ECO:0000313|EMBL:ALI05583.1};
UniProt sequence A0A0C4Y5S4: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AJG18233.1};
Curated sequence CH_088342: proton/sodium-glutamate symport protein GltT. Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein
Curated sequence P24943: Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein. proton/sodium-glutamate symport protein GltT. Glutamate/aspartate:Na+ + H+ symporter
Curated sequence P43003: Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3. Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)
Curated sequence CH_091614: excitatory amino acid transporter 1. Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3. Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers
Curated sequence O35544: Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
Curated sequence O35921: Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
Curated sequence O57321: Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST
Curated sequence O59010: Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter. Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+
Curated sequence P24943: Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein. proton/sodium-glutamate symport protein GltT. Glutamate/aspartate:Na+ + H+ symporter
Curated sequence P31596: Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2. Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1
Curated sequence P31597: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
Curated sequence P43004: Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2. Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Curated sequence P43005: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1. Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation
Curated sequence P43006: Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2
Curated sequence P46411: Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3
Curated sequence P48664: Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6. Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
Curated sequence P51906: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
Curated sequence P51907: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
Curated sequence P56564: Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3
Curated sequence Q9N1R2: Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
Curated sequence B0W0K4: EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas
Curated sequence Q10901: Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs
Curated sequence Q8T0S9: Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency
Curated sequence CH_088342: proton/sodium-glutamate symport protein GltT. Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein
Ignore hits to Q9N280 when looking for 'other' hits (glucuronosyltransferase (EC 2.4.1.17))
Curated sequence P39817: Proton/glutamate-aspartate symporter; Proton/glutamate symport protein
UniProt sequence A1S570: SubName: Full=Sodium:dicarboxylate symporter {ECO:0000313|EMBL:ABL99526.1};
Comment: The original cluster was entirely eukaryotic except for gltPh from Pyrococcus horikoshii. Added gltT from Bacillus caldotenax (CharProtDB::CH_088342), which is also an aspartate transporter. So, named it glt. Ignore Q9N280 which has a questionable annotation in BRENDA. But the more distantly related protein AO356_01905 (A0A0N9WTL5) also seems to be an aspartate transporter. Similarly, the related protein RR42_RS03990 (A0A0C4Y5S4) is specifically important for asparagine utilization. Asparagine is probably cleaved in the periplasm (by RR42_RS12610 or RR42_RS26140) so this is probably an aspartate transporter as well. And the related protein P24944 (CH_088342) or P24943 is an aspartate transporter. This cluster also includes the aspartate transporter DctA from E. coli; it is almost 80% identical to Pseudomonas dicarboxylate transporters whose activity on aspartate is uncertain. As these are not important for aspartate utilization (AO356_18980, AO353_02800), do not mark them as ignored. The gltP from B. subtilis (P39817) was added manually. A related aspartate/glutamate transporter was identified in Shewanella amazonensis SB2B (Sama_1319, A1S570) using fitness data.

Fetched 28 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 14 other characterized sequences. (Found 39 hits including self hits.)

Removing ignored items reduces this to 13 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for glt.)

DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: SDF
436 amino acids: PaperBLAST, CDD, SwissProt::Q9I4F5
77% identical to

b3528 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P0A830 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli (strain K12)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12)
GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli
PFams: SDF
428 amino acids: PaperBLAST, CDD

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD, TCDB::Q848I3
77% identical to

AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
PFams: SDF
450 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_18980
76% identical to

TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
PFams: SDF
444 amino acids: PaperBLAST, CDD, TCDB::Q01857
63% identical to

TC 2.A.23.2.12 / B0W0K5 Dicarboxylic acid over dicarboxylic amino acid from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD, TCDB::B0W0K5
64% identical to

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD

TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
PFams: SDF
442 amino acids: PaperBLAST, CDD, TCDB::Q1J1H5
62% identical to

TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis
PFams: SDF
421 amino acids: PaperBLAST, CDD, TCDB::P96603
56% identical to

TC 2.A.23.2.5 / O00341 solute carrier family 1 (glutamate transporter), member 7 from Homo sapiens
PFams: SDF
560 amino acids: PaperBLAST, CDD, TCDB::O00341
56% identical to

EAA1_HUMAN / P43003 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Homo sapiens (Human)
TC 2.A.23.2.6 / P43003 Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) from Homo sapiens
PFams: SDF
542 amino acids: PaperBLAST, CDD

SATT_HUMAN / P43007 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4 from Homo sapiens (Human)
TC 2.A.23.3.1 / P43007 Neutral amino acid (alanine, serine, cysteine, threonine):Na+ symporter. Also transports homocysteine (Jiang et al., 2007). AscT1 is the Syncytin-1 (Q9UQF0) receptor. Syncytin-1, of 538 aas with 4-7 TMSs, is a viral fusion protein and is involved in the development of multiple sclerosis (Antony et al. 2007). Mutation causes nuerological problems including global developmental delay, severe progressive microcephaly, seizures, spasticity and thin corpus callosum (CC) from Homo sapiens (Human)
RF|NP_003029.2 neutral amino acid transporter A from Homo sapiens
PFams: SDF
532 amino acids: PaperBLAST, CDD, CharProtDB::CH_091534
45% identical to

EAA3_MOUSE / P51906 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Mus musculus (Mouse)
PFams: SDF
523 amino acids: PaperBLAST, CDD

AAAT_BOVIN / Q95JC7 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Bos taurus (Bovine)
PFams: SDF
539 amino acids: PaperBLAST, CDD, SwissProt::Q95JC7
43% identical to

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD

AAAT_MOUSE / P51912 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Mus musculus (Mouse)
TC 2.A.23.3.2 / P51912 Insulin-activated, Na+-dependet amino acid (serine, alanine, glutamate, glutamine and other neutral amino acids):amino acid antiporter (Ndaru et al. 2019). Also transports homocysteine from Mus musculus (Mouse)
CH_091706 neutral amino acid transporter B(0) from Mus musculus
PFams: SDF
553 amino acids: PaperBLAST, CDD, CharProtDB::CH_091706
44% identical to

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD

AAAT_RABIT / O19105 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Oryctolagus cuniculus (Rabbit)
PFams: SDF
541 amino acids: PaperBLAST, CDD, SwissProt::O19105
44% identical to

EAA3_RABIT / P31597 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Oryctolagus cuniculus (Rabbit)
PFams: SDF
524 amino acids: PaperBLAST, CDD

AAAT_HUMAN / Q15758 Neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Homo sapiens (Human)
TC 2.A.23.3.3 / Q15758 Broad-specificity amino acid:Na+ symporter, LAT1, M7V1, RDR, RDRC or SLC1A5 (transports most neutral, zwitterionic and dibasic amino acids either uptake or bidirectional transport) (Scalise et al. 2018). Required for intracellular multiplication of Legionella pneumophila (Wieland et al., 2005). SLC7A5 with accessory protein SLC3A2 (the heavy chain; TC# 8.A.9.2.2) mediates bidirectional transport of amino acids and regulates mTOR and autophagy from Homo sapiens (Human)
RF|NP_005619.1 neutral amino acid transporter B(0) from Homo sapiens
PFams: SDF
541 amino acids: PaperBLAST, CDD, CharProtDB::CH_091239
41% identical to

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for glt.)

Q9N280 glucuronosyltransferase (EC 2.4.1.17) from Canis lupus familiaris
PFams: SDF
542 amino acids: PaperBLAST, CDD, BRENDA::Q9N280
97% identical to

EAA1_BOVIN / P46411 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Bos taurus (Bovine)
PFams: SDF
542 amino acids: PaperBLAST, CDD