# pathway asparagine step glt # Cluster 1 414-574 amino acids (not heteromeric) # UniProt::A1S570 Sodium:dicarboxylate symporter # CharProtDB::CH_014038,SwissProt::P0A830,TCDB::P0A830,ecocyc::DCTA-MONOMER,metacyc::DCTA-MONOMER GB|AAC76553.1;; DCTA_ECOLI;; 2.A.23.1.7;; b3528;; P0A830 aerobic C4-dicarboxylate transport protein;; Aerobic C4-dicarboxylate transport protein;; Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase;; C4 dicarboxylate/orotate:H+ symporter;; C4 dicarboxylate/orotate:H+ symporter Escherichia coli;; Escherichia coli (strain K12);; Escherichia coli (strain K12);; Escherichia coli K-12 substr. MG1655;; Escherichia coli (strain K12) # CharProtDB::CH_088342,SwissProt::P24944 GI|143002;; GLTT_BACCA proton/sodium-glutamate symport protein GltT;; Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein Bacillus caldotenax;; Bacillus caldotenax # CharProtDB::CH_091614,SwissProt::P24942,TCDB::P24942 RF|NP_062098.1;; EAA1_RAT;; 2.A.23.2.1 excitatory amino acid transporter 1;; Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3;; Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers Rattus norvegicus;; Rattus norvegicus (Rat);; Rattus norvegicus (Rat) # SwissProt::O57321 EAA1_AMBTI Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST Ambystoma tigrinum (Eastern tiger salamander) # SwissProt::O59010,TCDB::O59010 GLT_PYRHO;; 2.A.23.1.5 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter;; Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3);; Pyrococcus horikoshii # SwissProt::P21345,TCDB::P21345,ecocyc::GLTP-MONOMER GLTP_ECOLI;; 2.A.23.1.1;; b4077 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein;; Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5);; glutamate/aspartate : H+ symporter GltP Escherichia coli (strain K12);; Escherichia coli;; Escherichia coli K-12 substr. MG1655 # SwissProt::P24943,CharProtDB::CH_088341,TCDB::P24943 GLTT_GEOSE;; GI|143000;; 2.A.23.1.2 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein;; proton/sodium-glutamate symport protein GltT;; Glutamate/aspartate:Na+ + H+ symporter Geobacillus stearothermophilus (Bacillus stearothermophilus);; Geobacillus stearothermophilus;; Bacillus stearothermophilus # SwissProt::P31596,TCDB::P31596 EAA2_RAT;; 2.A.23.2.2 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2;; Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1 Rattus norvegicus (Rat);; Rattus norvegicus (Rat) # SwissProt::P31597 EAA3_RABIT Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Oryctolagus cuniculus (Rabbit) # SwissProt::P39817 GLTP_BACSU Proton/glutamate-aspartate symporter; Proton/glutamate symport protein Bacillus subtilis (strain 168) # SwissProt::P43003,TCDB::P43003 EAA1_HUMAN;; 2.A.23.2.6 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3;; Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) Homo sapiens (Human);; Homo sapiens # SwissProt::P43004,TCDB::P43004 EAA2_HUMAN;; 2.A.23.2.7 Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2;; Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Homo sapiens (Human);; Homo sapiens # SwissProt::P43005,TCDB::P43005 EAA3_HUMAN;; 2.A.23.2.3 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1;; Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation Homo sapiens (Human);; Homo sapiens (Human) # SwissProt::P43006 EAA2_MOUSE Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 Mus musculus (Mouse) # SwissProt::P46411 EAA1_BOVIN Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 Bos taurus (Bovine) # SwissProt::P51906 EAA3_MOUSE Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Mus musculus (Mouse) # SwissProt::P51907 EAA3_RAT Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Rattus norvegicus (Rat) # SwissProt::P56564 EAA1_MOUSE Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 Mus musculus (Mouse) # TCDB::B0W0K4 2.A.23.2.11 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas Culex quinquefasciatus # TCDB::Q10901 2.A.23.2.10 Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs Caenorhabditis elegans # UniProt::A0A0C4Y5S4 Uncharacterized protein # UniProt::A0A0N9WTL5 Amino acid:proton symporter Cluster1 Sodium:dicarboxylate symporter curated:UniProt::A1S570 curated:CharProtDB::CH_014038 curated:CharProtDB::CH_088342 curated:CharProtDB::CH_091614 curated:SwissProt::O57321 curated:SwissProt::O59010 curated:SwissProt::P21345 curated:SwissProt::P24943 curated:SwissProt::P31596 curated:SwissProt::P31597 curated:SwissProt::P39817 curated:SwissProt::P43003 curated:SwissProt::P43004 curated:SwissProt::P43005 curated:SwissProt::P43006 curated:SwissProt::P46411 curated:SwissProt::P51906 curated:SwissProt::P51907 curated:SwissProt::P56564 curated:TCDB::B0W0K4 curated:TCDB::Q10901 curated:UniProt::A0A0C4Y5S4 curated:UniProt::A0A0N9WTL5 # Cluster 2 561-579 amino acids (not heteromeric) # SwissProt::O35544 EAA4_MOUSE Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Mus musculus (Mouse) # SwissProt::O35921 EAA4_RAT Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Rattus norvegicus (Rat) # SwissProt::P48664,TCDB::P48664 EAA4_HUMAN;; 2.A.23.2.8 Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6;; Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) Homo sapiens (Human);; Homo sapiens # SwissProt::Q9N1R2 EAA4_CANLF Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Canis lupus familiaris (Dog) (Canis familiaris) # TCDB::Q8T0S9 2.A.23.2.4 Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency Drosophila melanogaster (Fruit fly) Cluster2 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 curated:SwissProt::O35544 curated:SwissProt::O35921 curated:SwissProt::P48664 curated:SwissProt::Q9N1R2 curated:TCDB::Q8T0S9