Sequence Cluster id id2 desc organism isHeteromeric 1 Cluster1 UniProt::A1S570 Sodium:dicarboxylate symporter 2 Cluster1 CharProtDB::CH_014038 GB|AAC76553.1 aerobic C4-dicarboxylate transport protein Escherichia coli 2 Cluster1 SwissProt::P0A830 DCTA_ECOLI Aerobic C4-dicarboxylate transport protein Escherichia coli (strain K12) 2 Cluster1 TCDB::P0A830 2.A.23.1.7 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase Escherichia coli (strain K12) 2 Cluster1 ecocyc::DCTA-MONOMER b3528 C4 dicarboxylate/orotate:H+ symporter Escherichia coli K-12 substr. MG1655 2 Cluster1 metacyc::DCTA-MONOMER P0A830 C4 dicarboxylate/orotate:H+ symporter Escherichia coli (strain K12) 3 Cluster1 CharProtDB::CH_088342 GI|143002 proton/sodium-glutamate symport protein GltT Bacillus caldotenax 3 Cluster1 SwissProt::P24944 GLTT_BACCA Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein Bacillus caldotenax 4 Cluster1 CharProtDB::CH_091614 RF|NP_062098.1 excitatory amino acid transporter 1 Rattus norvegicus 4 Cluster1 SwissProt::P24942 EAA1_RAT Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3 Rattus norvegicus (Rat) 4 Cluster1 TCDB::P24942 2.A.23.2.1 Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers Rattus norvegicus (Rat) 5 Cluster1 SwissProt::O57321 EAA1_AMBTI Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST Ambystoma tigrinum (Eastern tiger salamander) 6 Cluster1 SwissProt::O59010 GLT_PYRHO Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 6 Cluster1 TCDB::O59010 2.A.23.1.5 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ Pyrococcus horikoshii 7 Cluster1 SwissProt::P21345 GLTP_ECOLI Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein Escherichia coli (strain K12) 7 Cluster1 TCDB::P21345 2.A.23.1.1 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) Escherichia coli 7 Cluster1 ecocyc::GLTP-MONOMER b4077 glutamate/aspartate : H+ symporter GltP Escherichia coli K-12 substr. MG1655 8 Cluster1 SwissProt::P24943 GLTT_GEOSE Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein Geobacillus stearothermophilus (Bacillus stearothermophilus) 8 Cluster1 CharProtDB::CH_088341 GI|143000 proton/sodium-glutamate symport protein GltT Geobacillus stearothermophilus 8 Cluster1 TCDB::P24943 2.A.23.1.2 Glutamate/aspartate:Na+ + H+ symporter Bacillus stearothermophilus 9 Cluster1 SwissProt::P31596 EAA2_RAT Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 Rattus norvegicus (Rat) 9 Cluster1 TCDB::P31596 2.A.23.2.2 Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1 Rattus norvegicus (Rat) 10 Cluster1 SwissProt::P31597 EAA3_RABIT Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Oryctolagus cuniculus (Rabbit) 11 Cluster1 SwissProt::P39817 GLTP_BACSU Proton/glutamate-aspartate symporter; Proton/glutamate symport protein Bacillus subtilis (strain 168) 12 Cluster1 SwissProt::P43003 EAA1_HUMAN Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 Homo sapiens (Human) 12 Cluster1 TCDB::P43003 2.A.23.2.6 Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) Homo sapiens 13 Cluster1 SwissProt::P43004 EAA2_HUMAN Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 Homo sapiens (Human) 13 Cluster1 TCDB::P43004 2.A.23.2.7 Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Homo sapiens 14 Cluster1 SwissProt::P43005 EAA3_HUMAN Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Homo sapiens (Human) 14 Cluster1 TCDB::P43005 2.A.23.2.3 Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation Homo sapiens (Human) 15 Cluster1 SwissProt::P43006 EAA2_MOUSE Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 Mus musculus (Mouse) 16 Cluster1 SwissProt::P46411 EAA1_BOVIN Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 Bos taurus (Bovine) 17 Cluster1 SwissProt::P51906 EAA3_MOUSE Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Mus musculus (Mouse) 18 Cluster1 SwissProt::P51907 EAA3_RAT Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 Rattus norvegicus (Rat) 19 Cluster1 SwissProt::P56564 EAA1_MOUSE Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 Mus musculus (Mouse) 20 Cluster1 TCDB::B0W0K4 2.A.23.2.11 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas Culex quinquefasciatus 21 Cluster1 TCDB::Q10901 2.A.23.2.10 Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs Caenorhabditis elegans 22 Cluster1 UniProt::A0A0C4Y5S4 Uncharacterized protein 23 Cluster1 UniProt::A0A0N9WTL5 Amino acid:proton symporter 24 Cluster2 SwissProt::O35544 EAA4_MOUSE Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Mus musculus (Mouse) 25 Cluster2 SwissProt::O35921 EAA4_RAT Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Rattus norvegicus (Rat) 26 Cluster2 SwissProt::P48664 EAA4_HUMAN Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Homo sapiens (Human) 26 Cluster2 TCDB::P48664 2.A.23.2.8 Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) Homo sapiens 27 Cluster2 SwissProt::Q9N1R2 EAA4_CANLF Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 Canis lupus familiaris (Dog) (Canis familiaris) 28 Cluster2 TCDB::Q8T0S9 2.A.23.2.4 Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency Drosophila melanogaster (Fruit fly)