Clusters of Characterized Proteins

Clustering the characterized proteins for celEIIA (cellobiose PTS system, EII-A component) in D-cellobiose catabolism

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Definition of celEIIA

• Curated sequence P69791: PTS system N,N'-diacetylchitobiose-specific EIIA component; EIIA-Chb; EIII-Chb; IIIcel; N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component. PTCA aka ChbA aka CELC aka B1736, component of N,N'-diacetylchitobiose (Chb) porter. N,N'-diacetylchitobiose-specific PTS enzyme IIA component (EC 2.7.1.196). N,N'-diacetylchitobiose-specific PTS enzyme IIA component (EC 2.7.1.196)
• Curated sequence Q9CIE9: PTS system cellobiose-specific EIIA component. PtcA, component of The cellobiose-specific (PtcA-PtcB-CelB) porter (Kowalczyk et al., 2008 )
• UniProt sequence A0A0H2UNC0: SubName: Full=PTS system, IIA component {ECO:0000313|EMBL:AAK74485.1};
• Ignore hits to A2RIE7 when looking for 'other' hits (PTS system galactose-specific EIIA component)
• Ignore hits to C4X746 when looking for 'other' hits (PEP-dependent phosphotransferase enzyme III, component of N,N'-diacetylchitobiose (cellobiose) PTS permease, CelABC (IIABC))
• Comment: E. coli also has chbABC (separate EII-A, EII-B and EII-C components), and Lactococcus lactis has a similar system (ptcA-ptcB-celB). Separate EIIABC proteins are also known in Streptococcus pneumoniae, see PMC3302838. (SP0308 = celC = EIIA = A0A0H2UNC0; Sp0305 = celB = EIIB = A0A0H2UNC2; SP0310 = celD = EIIC = A0A0H2UNC6.) Ignore a close homolog from L. lactis cremoris (annotated as galactose-specific) and a systems from Klebsiella pneumoniae and Serratia marcescens that may transport cellobiose.

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 104-116 amino acids (2/3 heteromeric)

b1736 N,N'-diacetylchitobiose-specific PTS enzyme IIA component (EC 2.7.1.196) from Escherichia coli K-12 substr. MG1655
P69791 N,N'-diacetylchitobiose-specific PTS enzyme IIA component (EC 2.7.1.196) from Escherichia coli (strain K12)
PTQA_ECOLI / P69791 PTS system N,N'-diacetylchitobiose-specific EIIA component; EIIA-Chb; EIII-Chb; IIIcel; N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12)
TC 4.A.3.2.1 / P69791 PTCA aka ChbA aka CELC aka B1736, component of N,N'-diacetylchitobiose (Chb) porter from Escherichia coli
PFams: PTS_IIA
Heteromeric, 116 amino acids: PaperBLAST, CDD, Compare to cluster

PTCA_LACLA / Q9CIE9 PTS system cellobiose-specific EIIA component from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
TC 4.A.3.2.4 / Q9CIE9 PtcA, component of The cellobiose-specific (PtcA-PtcB-CelB) porter (Kowalczyk et al., 2008 ) from Lactococcus lactis subsp. lactis (Streptococcus lactis)
PFams: PTS_IIA
Heteromeric, 116 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0H2UNC0 PTS system, IIA component
104 amino acids: PaperBLAST, CDD, Compare to cluster