Other Characterized Proteins Similar to icd

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to icd

Finding the characterized proteins for icd (isocitrate dehydrogenase) in citrate catabolism

Or see clustering for step icd

Or see all steps for citrate catabolism

Or cluster curated proteins matching a keyword

Definition of icd

Curated proteins or TIGRFams with EC 1.1.1.41
Curated proteins or TIGRFams with EC 1.1.1.42
Curated proteins or TIGRFams with EC 1.1.1.286
Comment: Eukaryotic icd is heteromeric, but the regulatory subunits are similar to the enzymatic subunits, so this is not represented here

Fetched 75 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 19 other characterized sequences. (Found 94 hits including self hits.)

There are also 1 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for icd.)

LEU3_METJA / Q58130 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58130 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
PFams: Iso_dh
333 amino acids: PaperBLAST, CDD, SwissProt::Q58130
53% identical to

HICDH_THET8 / Q5SIJ1 Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.87 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
HICDH_THET2 / Q72IW9 Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.87 from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Q5SIJ1 homoisocitrate dehydrogenase (EC 1.1.1.87) from Thermus thermophilus
Q72IW9 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286); 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
Q5SIJ1 homoisocitrate dehydrogenase subunit (EC 1.1.1.87) from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
PFams: Iso_dh
334 amino acids: PaperBLAST, CDD

LEU3_HALVD / D4GYE8 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
PFams: Iso_dh
324 amino acids: PaperBLAST, CDD, SwissProt::D4GYE8
50% identical to

AKSF_METJA / Q58991 Homoisocitrate dehydrogenase; HICDH; Isohomocitrate dehydrogenase; IHDH; NAD-dependent threo-isohomocitrate dehydrogenase; EC 1.1.1.87 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58991 methanogen homoaconitase (EC 4.2.1.114) from Methanocaldococcus jannaschii
Q58991 NAD-dependent threo-isocitrate dehydrogenase (EC 1.1.1.87) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
PFams: Iso_dh
347 amino acids: PaperBLAST, CDD, SwissProt::Q58991
48% identical to

LYS12_YEAST / P40495 Homoisocitrate dehydrogenase, mitochondrial; HIcDH; EC 1.1.1.87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P40495 homoisocitrate dehydrogenase (EC 1.1.1.87) from Saccharomyces cerevisiae
PFams: Iso_dh
371 amino acids: PaperBLAST, CDD, BRENDA::P40495
48% identical to

Q76LM6 oxalosuccinate reductase subunit from Hydrogenobacter thermophilus
PFams: Iso_dh
421 amino acids: PaperBLAST, CDD, metacyc::MONOMER-11846
47% identical to

Q8U488 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Pyrococcus furiosus
PFams: Iso_dh
400 amino acids: PaperBLAST, CDD

LYS12_SCHPO / O14104 Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.87 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Iso_dh
362 amino acids: PaperBLAST, CDD, SwissProt::O14104
47% identical to

P24098 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus aquaticus
PFams: Iso_dh
344 amino acids: PaperBLAST, CDD, BRENDA::P24098
45% identical to

P61495 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD, BRENDA::P61495
45% identical to

LEU3_THET8 / Q5SIY4 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Q5SIY4 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD, BRENDA::Q5SIY4
45% identical to

P61494 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD, BRENDA::P61494
44% identical to

LEU3_SULTO / P50455 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
P50455 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD, SwissProt::P50455
42% identical to

Q4JB37 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD, BRENDA::Q4JB37
41% identical to

LEU3_ACIFR / Q56268 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
Q56268 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Acidithiobacillus ferrooxidans
PFams: Iso_dh
358 amino acids: PaperBLAST, CDD, SwissProt::Q56268
41% identical to

LEU3_BACCO / P12010 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Bacillus coagulans
PFams: Iso_dh
366 amino acids: PaperBLAST, CDD, SwissProt::P12010
40% identical to

P94929 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mycobacterium tuberculosis variant bovis
PFams: Iso_dh
336 amino acids: PaperBLAST, CDD, BRENDA::P94929
42% identical to

LEU3_MYCTU / P9WKK9 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Iso_dh
336 amino acids: PaperBLAST, CDD, SwissProt::P9WKK9
41% identical to

LEU31_ARATH / Q9FMT1 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress)
Q9FMT1 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana
Q9FMT1 isopropylmalate dehydrogenase 3 (EC 1.1.1.85) from Arabidopsis thaliana
PFams: Iso_dh
409 amino acids: PaperBLAST, CDD, BRENDA::Q9FMT1
40% identical to

Q00412 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arthrospira platensis
PFams: Iso_dh
355 amino acids: PaperBLAST, CDD, BRENDA::Q00412
40% identical to

Q0X0C1 (2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate dehydrogenase from Streptomyces lasaliensis
PFams: Iso_dh
362 amino acids: PaperBLAST, CDD, metacyc::MONOMER-19585
40% identical to

Q5JFV8 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286) from Thermococcus kodakarensis
PFams: Iso_dh
347 amino acids: PaperBLAST, CDD

HMM-only sequences

(Since these sequences' annotations are outside the definition for icd, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

IDHG2_MOUSE / Q8BPC6 Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Isocitric dehydrogenase subunit gamma 2; NAD(+)-specific ICDH subunit gamma 2 from Mus musculus (Mouse)
PFams: Iso_dh
Heteromeric, 396 amino acids: PaperBLAST, CDD