Other Characterized Proteins Similar to nupC

Finding the characterized proteins for nupC (deoxyinosine:H+ symporter NupC) in 2'-deoxyinosine catabolism

Or see clustering for step nupC

Or see all steps for 2'-deoxyinosine catabolism

Or cluster curated proteins matching a keyword

Definition of nupC

• Curated sequence O25792: Nucleoside permease NupC
• Curated sequence P0AFF2: Nucleoside permease NupC; Nucleoside-transport system protein NupC. Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system. nucleoside:H⁺ symporter NupC. nucleoside:H⁺ symporter NupC
• Curated sequence P42312: Purine nucleoside transport protein NupG. The purine nucleoside uptake transporter NupG (YxjA)
• Curated sequence Q9KPL5: Concentrative nucleoside transporter, CNT, of 418 aas and 12 TMSs. A repeat-swapped model of VcCNT predicts that nucleoside transport occurs via a mechanism involving an elevator-like substrate binding domain movement across the membrane
• Ignore hits to P33021 when looking for 'other' hits (Putative nucleoside permease NupX. Nucleoside permease NupX. putative nucleoside transporter)
• Comment: These proteins are reported to transport inosine, and likely transport deoxyinosine as well. The specificity of E. coli nupX (P33021, also known as yeiJ) seems to be unknown.

Fetched 4 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 2 other characterized sequences. (Found 6 hits including self hits.)

Removing ignored items reduces this to 1 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for nupC.)

NUPC_BACSU / P39141 Nucleoside permease NupC from Bacillus subtilis (strain 168)
TC 2.A.41.1.2 / P39141 Pyrimidine-specific nucleoside:H+ symporter, NupC from Bacillus subtilis
PFams: Nucleos_tra2_N, Nucleos_tra2_C
393 amino acids: PaperBLAST, CDD, SwissProt::P39141
60% identical to

b2393 nucleoside:H⁺ symporter NupC from Escherichia coli K-12 substr. MG1655
P0AFF2 nucleoside:H⁺ symporter NupC from Escherichia coli (strain K12)
NUPC_ECOLI / P0AFF2 Nucleoside permease NupC; Nucleoside-transport system protein NupC from Escherichia coli (strain K12)
TC 2.A.41.1.1 / P0AFF2 Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system from Escherichia coli
PFams: Nucleos_tra2_N, Gate, Nucleos_tra2_C
400 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for nupC.)

P33021 putative nucleoside transporter from Escherichia coli (strain K12)
NUPX_ECOLI / P33021 Putative nucleoside permease NupX from Escherichia coli (strain K12)
TC 2.A.41.2.10 / P33021 Nucleoside permease NupX from Escherichia coli (strain K12)
PFams: Nucleos_tra2_N, Nucleos_tra2_C
416 amino acids: PaperBLAST, CDD, SwissProt::P33021
50% identical to

TC 2.A.41.2.11 / Q9KPL5 Concentrative nucleoside transporter, CNT, of 418 aas and 12 TMSs. A repeat-swapped model of VcCNT predicts that nucleoside transport occurs via a mechanism involving an elevator-like substrate binding domain movement across the membrane from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
PFams: Nucleos_tra2_N, Gate, Nucleos_tra2_C
418 amino acids: PaperBLAST, CDD