# pathway deoxyinosine step nupC # Cluster 1 397-400 amino acids (not heteromeric) # SwissProt::P0AFF2,TCDB::P0AFF2,ecocyc::NUPC-MONOMER,metacyc::NUPC-MONOMER NUPC_ECOLI;; 2.A.41.1.1;; b2393;; P0AFF2 Nucleoside permease NupC; Nucleoside-transport system protein NupC;; Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system;; nucleoside:H+ symporter NupC;; nucleoside:H+ symporter NupC Escherichia coli (strain K12);; Escherichia coli;; Escherichia coli K-12 substr. MG1655;; Escherichia coli (strain K12) # SwissProt::P42312,TCDB::P42312 NUPG_BACSU;; 2.A.41.1.3 Purine nucleoside transport protein NupG;; The purine nucleoside uptake transporter NupG (YxjA) Bacillus subtilis (strain 168);; Bacillus subtilis Cluster1 Nucleoside permease NupC; Nucleoside-transport system protein NupC;; Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system;; nucleoside:H+ symporter NupC;; nucleoside:H+ symporter NupC curated:SwissProt::P0AFF2 curated:SwissProt::P42312 # Cluster 2 418-418 amino acids (not heteromeric) # SwissProt::O25792 NUPC_HELPY Nucleoside permease NupC Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) # TCDB::Q9KPL5 2.A.41.2.11 Concentrative nucleoside transporter, CNT, of 418 aas and 12 TMSs. A repeat-swapped model of VcCNT predicts that nucleoside transport occurs via a mechanism involving an elevator-like substrate binding domain movement across the membrane Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Cluster2 Nucleoside permease NupC curated:SwissProt::O25792 curated:TCDB::Q9KPL5