Other Characterized Proteins Similar to Slc2a5

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to Slc2a5

Finding the characterized proteins for Slc2a5 (fructose:H+ symporter) in D-fructose catabolism

Or see clustering for step Slc2a5

Or see all steps for D-fructose catabolism

Or cluster curated proteins matching a keyword

Definition of Slc2a5

Curated sequence A0ZXK6: The monosaccharide (MST) (glucose > mannose > galactose > fructose):H+ symporter, MST1
Curated sequence CH_091463: sugar transport protein 13. The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death
Curated sequence P22732: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5. Fructose uniporter, GLUT5
Curated sequence P43427: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence P46408: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence P58353: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Ignore hits to Q6PXP3 when looking for 'other' hits (Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7. The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport)
Curated sequence Q9WV38: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence Q9XIH7: The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). Also transports other substrates at lower rates. PMT2 is largely of the same sequence and function. Both are present in pollen and young xylem cells (Klepek et al., 2005). A similar ortholog has been identifed in pollen grains of Petunia hybrida
Comment: Ignore Q6PXP3 (GTR7_HUMAN) as there is debate as to its activity

Fetched 8 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 45 other characterized sequences. (Found 53 hits including self hits.)

Removing ignored items reduces this to 44 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for Slc2a5.)

MST4_ORYSJ / Q10PW9 Sugar transport protein MST4; Monosaccharide transporter 4; OsMST4; Sugar:proton symporter MST4 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
515 amino acids: PaperBLAST, CDD, SwissProt::Q10PW9
82% identical to

TC 2.A.1.1.50 / Q94AZ2 The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_198006.1 sugar transport protein 13 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
526 amino acids: PaperBLAST, CDD

TC 2.A.1.1.79 / Q1XF07 Polyol (xylitol):H+ symporter, PLT4 from Lotus japonicus
PFams: Sugar_tr, MFS_1
519 amino acids: PaperBLAST, CDD, TCDB::Q1XF07
66% identical to

TC 2.A.1.1.75 / Q9XIH7 The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). Also transports other substrates at lower rates. PMT2 is largely of the same sequence and function. Both are present in pollen and young xylem cells (Klepek et al., 2005). A similar ortholog has been identifed in pollen grains of Petunia hybrida from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
511 amino acids: PaperBLAST, CDD

PLT5_ARATH / Q8VZ80 Polyol transporter 5; Protein POLYOL TRANSPORTER 5; AtPLT5; Sugar-proton symporter PLT5 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.34 / Q8VZ80 The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H+ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_188513.1 polyol transporter 5 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
539 amino acids: PaperBLAST, CDD, CharProtDB::CH_091483
67% identical to

TC 2.A.1.1.123 / AIU41385.1 Sorbitol (D-Glucitol):H+ co-transporter, SOT1 (Km for sorbitol of 0.64 mM) of 509 aas and 12 TMSs (Gao et al. 2003). SOT1 of P. cerasus is expressed throughout fruit development, but especially when growth and sorbitol accumulation rates are highest. In leaves, PcSOT1 expression is highest in young, expanding tissues, but substantially less in mature leaves from Prunus salicina
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, TCDB::AIU41385.1
62% identical to

TC 2.A.1.1.122 / AGG19156.1 Sorbitol (glucitol):H+ co-transporter, SOT2 (Km for sorbitol of 0.81 mM) of 491 aas and 12 TMSs (Gao et al. 2003). SOT2 of Prunus cerasus is mainly expressed only early in fruit development and not in leaves from Pyrus pyrifolia
PFams: Sugar_tr, MFS_1
491 amino acids: PaperBLAST, CDD, TCDB::AGG19156.1
64% identical to

MST6_ORYSJ / Q6Z401 Sugar transport protein MST6; Monosaccharide transporter 6; OsMST5; Sugar:proton symporter MST6 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
530 amino acids: PaperBLAST, CDD, SwissProt::Q6Z401
59% identical to

MST3_ORYSJ / Q7EZD7 Sugar transport protein MST3; Monosaccharide transporter 3; OsMST3; Sugar:proton symporter MST3 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
518 amino acids: PaperBLAST, CDD, SwissProt::Q7EZD7
60% identical to

STP7_ARATH / O04249 Sugar transport protein 7; Hexose transporter 7 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1
513 amino acids: PaperBLAST, CDD, SwissProt::O04249
61% identical to

STP1_ARATH / P23586 Sugar transport protein 1; Glucose transporter; Hexose transporter 1 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.60 / P23586 The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_172592.1 sugar transport protein 1 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
522 amino acids: PaperBLAST, CDD, CharProtDB::CH_091695
58% identical to

STP6_ARATH / Q9SFG0 Sugar transport protein 6; Hexose transporter 6 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.56 / Q9SFG0 High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_187247.1 sugar transport protein 6 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
507 amino acids: PaperBLAST, CDD, CharProtDB::CH_091493
58% identical to

MST8_ORYSJ / Q94EC4 Sugar transport protein MST8; Monosaccharide transporter 8; OsMST8; Sugar:proton symporter MST8 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1, TRI12
513 amino acids: PaperBLAST, CDD, SwissProt::Q94EC4
59% identical to

MST5_ORYSJ / Q6ZKF0 Sugar transport protein MST5; Monosaccharide transporter 5; OsMST5; Sugar:proton symporter MST5 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
519 amino acids: PaperBLAST, CDD, SwissProt::Q6ZKF0
56% identical to

STP11_ARATH / Q9FMX3 Sugar transport protein 11; Hexose transporter 11 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.61 / Q9FMX3 High affinity monosaccharide (Km = 25 µM) transporter (takes up glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose), STP11 (expressed in pollen tubes) from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1
514 amino acids: PaperBLAST, CDD, SwissProt::Q9FMX3
57% identical to

STP9_ARATH / Q9SX48 Sugar transport protein 9; Hexose transporter 9 from Arabidopsis thaliana (Mouse-ear cress)
PFams: MFS_1, Sugar_tr
517 amino acids: PaperBLAST, CDD, SwissProt::Q9SX48
55% identical to

MST7_ORYSJ / Q94EC3 Sugar transport protein MST7; Monosaccharide transporter 7; OsMST7; Sugar:proton symporter MST7 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
512 amino acids: PaperBLAST, CDD, SwissProt::Q94EC3
58% identical to

TC 2.A.1.1.124 / Q9LT15 The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4 from Arabidopsis thaliana
PFams: MFS_1, Sugar_tr
514 amino acids: PaperBLAST, CDD, TCDB::Q9LT15
55% identical to

STP4_ARATH / Q39228 Sugar transport protein 4; Hexose transporter 4 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.49 / Q39228 The sink-specific, stress-regulated monosaccharide uptake porter, STP4. (Induced upon wounding or infection with bacteria or fungi; expressed in roots and flowers) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_188627.1 sugar transport protein 4 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
514 amino acids: PaperBLAST, CDD, CharProtDB::CH_091568
54% identical to

MST2_ORYSJ / Q851G4 Sugar transport protein MST2; Monosaccharide transporter 2; OsMST2; Sugar:proton symporter MST2 from Oryza sativa subsp. japonica (Rice)
PFams: Sugar_tr, MFS_1
522 amino acids: PaperBLAST, CDD, SwissProt::Q851G4
54% identical to

STP2_ARATH / Q9LNV3 Sugar transport protein 2; Hexose transporter 2 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.48 / Q9LNV3 The pentose/hexose transporter (sugar transport protein 2), STP2. (Expressed during pollen maturation and early stages of gametophyte development) from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1
498 amino acids: PaperBLAST, CDD, SwissProt::Q9LNV3
52% identical to

TC 2.A.1.1.14 / P15686 Hexose:H+ symporter of 534 aas and 12 TMSs from Chlorella kessleri
PFams: Sugar_tr, MFS_1
534 amino acids: PaperBLAST, CDD, TCDB::P15686
49% identical to

GTR9_MOUSE / Q3T9X0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1, MFS_1
538 amino acids: PaperBLAST, CDD, SwissProt::Q3T9X0
45% identical to

GTR5_MOUSE / Q9WV38 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD

TC 2.A.1.1.47 / Q5ERC7 The embryonic liver, kidney, and other tissue uric acid (urate) transporter, Glut9 (SLC2A9) (Wright et al. 2010). Mutations in this transporter cause severe renal hyperuricemia from Mus musculus (Mouse)
RF|NP_001012363.2 glucose transporter 9b from Mus musculus
PFams: Sugar_tr, MFS_1
523 amino acids: PaperBLAST, CDD, CharProtDB::CH_091552
45% identical to

GTR9_HUMAN / Q9NRM0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
540 amino acids: PaperBLAST, CDD, SwissProt::Q9NRM0
46% identical to

GTR5_BOVIN / P58353 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD

TC 2.A.1.1.72 / Q9NRM0 The kidney basolateral urate efflux transporter (SLC2A9, URATv1 or GLUT9) (orthologue of 2.A.1.1.47) (Anzai et al., 2008). Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses from Homo sapiens
PFams: Sugar_tr, MFS_1
540 amino acids: PaperBLAST, CDD, TCDB::Q9NRM0
46% identical to

GTR3_MOUSE / P32037 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
493 amino acids: PaperBLAST, CDD, SwissProt::P32037
44% identical to

GTR3_RABIT / Q9XSC2 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Oryctolagus cuniculus (Rabbit)
PFams: Sugar_tr, MFS_1
494 amino acids: PaperBLAST, CDD, SwissProt::Q9XSC2
44% identical to

GLUT4_HUMAN / P14672 Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4 from Homo sapiens (Human)
TC 2.A.1.1.80 / P14672 Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM) from Homo sapiens
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, SwissProt::P14672
43% identical to

GTR5_HUMAN / P22732 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Homo sapiens (Human)
TC 2.A.1.1.13 / P22732 Fructose uniporter, GLUT5
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD

GLUT4_RAT / P19357 Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, SwissProt::P19357
42% identical to

GTR5_RAT / P43427 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Rattus norvegicus (Rat)
PFams: MFS_1, Sugar_tr
502 amino acids: PaperBLAST, CDD

TC 2.A.1.1.130 / Q63ZP5 Glucose transporter 1, GLUT1 or Slc2A1 of 491 aas and 12 TMSs from Xenopus laevis
PFams: Sugar_tr, MFS_1
491 amino acids: PaperBLAST, CDD, TCDB::Q63ZP5
42% identical to

GTR3_RAT / Q07647 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Rattus norvegicus (Rat)
TC 2.A.1.1.12 / Q07647 Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b) from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
493 amino acids: PaperBLAST, CDD, SwissProt::Q07647
43% identical to

GTR1_MOUSE / P17809 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, SwissProt::P17809
43% identical to

GTR1_RAT / P11167 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, SwissProt::P11167
42% identical to

GLUT4_MOUSE / P14142 Solute carrier family 2, facilitated glucose transporter member 4; GT2; Glucose transporter type 4, insulin-responsive; GLUT-4 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, SwissProt::P14142
43% identical to

GTR3_SHEEP / P47843 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Ovis aries (Sheep)
PFams: Sugar_tr, MFS_1
494 amino acids: PaperBLAST, CDD, SwissProt::P47843
43% identical to

GTR1_BOVIN / P27674 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, SwissProt::P27674
44% identical to

GTR1_HUMAN / P11166 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter from Homo sapiens (Human)
TC 2.A.1.1.28 / P11166 The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, SwissProt::P11166
44% identical to

GTR3_HUMAN / P11169 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Homo sapiens (Human)
TC 2.A.1.1.91 / P11169 Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose from Homo sapiens
PFams: Sugar_tr, MFS_1
496 amino acids: PaperBLAST, CDD, SwissProt::P11169
42% identical to

GTR14_HUMAN / Q8TDB8 Solute carrier family 2, facilitated glucose transporter member 14; Glucose transporter type 14; GLUT-14 from Homo sapiens (Human)
TC 2.A.1.1.90 / Q8TDB8 Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) from Homo sapiens
PFams: Sugar_tr, MFS_1
520 amino acids: PaperBLAST, CDD, SwissProt::Q8TDB8
41% identical to

GTR11_HUMAN / Q9BYW1 Solute carrier family 2, facilitated glucose transporter member 11; Glucose transporter type 11; GLUT-11 from Homo sapiens (Human)
TC 2.A.1.1.44 / Q9BYW1 The hexose (glucose and fructose but not galactose) transporter (Glut11; SLC2A11) from Homo sapiens
PFams: Sugar_tr, MFS_1
496 amino acids: PaperBLAST, CDD, SwissProt::Q9BYW1
42% identical to

TC 2.A.1.1.86 / H9BPB6 The sea bream facilitative glucose transporter 1 (GLUT1) from Sparus aurata
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, TCDB::H9BPB6
41% identical to

GTR1_DROME / Q8IRI6 Glucose transporter type 1 from Drosophila melanogaster (Fruit fly)
PFams: Sugar_tr, MFS_1
1440 amino acids: PaperBLAST, CDD, SwissProt::Q8IRI6
40% identical to

GTR2_HUMAN / P11168 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Homo sapiens (Human)
TC 2.A.1.1.29 / P11168 Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011; from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
524 amino acids: PaperBLAST, CDD, SwissProt::P11168
41% identical to

GTR2_MOUSE / P14246 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1, Folate_carrier
523 amino acids: PaperBLAST, CDD, SwissProt::P14246
40% identical to

GTR2_RAT / P12336 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1, Folate_carrier
522 amino acids: PaperBLAST, CDD, SwissProt::P12336
40% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for Slc2a5.)

GTR7_HUMAN / Q6PXP3 Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7 from Homo sapiens (Human)
TC 2.A.1.1.37 / Q6PXP3 The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
512 amino acids: PaperBLAST, CDD, SwissProt::Q6PXP3
60% identical to