Other Characterized Proteins Similar to levDE

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to levDE

Finding the characterized proteins for levDE (fructose PTS system (fructose 6-phosphate forming), EII-AB component) in D-fructose catabolism

Or see clustering for step levDE

Or see all steps for D-fructose catabolism

Or cluster curated proteins matching a keyword

Definition of levDE

Curated sequence CH_088329: PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191. PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIAB component
Curated sequence Q04GK1: Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system
Curated sequence Q5M5W6: ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
Ignore hits to Q9S4L5 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
Ignore hits to D2BKY7 when looking for 'other' hits (Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine)
Comment: Q9S4L5 is nearly identical to Q5M5W6; not sure if it acts on fructose or not. D2BKY7 is very similar to Q5M5W6 and has been studied mostly as a receptor to bacteriocins; not sure if it acts on fructose or not.

Fetched 3 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 4 other characterized sequences. (Found 7 hits including self hits.)

Removing ignored items reduces this to 2 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for levDE.)

TC 4.A.6.1.15 / E1UCI0 PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 321 amino acids: PaperBLAST, CDD, TCDB::E1UCI0
62% identical to

TC 4.A.6.1.10 / Q04GK1 Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 331 amino acids: PaperBLAST, CDD

TC 4.A.6.1.6 / Q2QKM4 ManL aka EIIAB, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 324 amino acids: PaperBLAST, CDD, TCDB::Q2QKM4
59% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for levDE.)

Q9S4L5 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Streptococcus salivarius
PFams: EIIA-man, PTSIIB_sorb
330 amino acids: PaperBLAST, CDD, BRENDA::Q9S4L5
96% identical to

TC 4.A.6.1.7 / Q5M5W6 ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 330 amino acids: PaperBLAST, CDD

TC 4.A.6.1.11 / D2BKY7 Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 329 amino acids: PaperBLAST, CDD, TCDB::D2BKY7
76% identical to