Other Characterized Proteins Similar to KDF-hydrolase

Finding the characterized proteins for KDF-hydrolase (2,4-diketo-3-deoxy-L-fuconate hydrolase) in L-fucose catabolism

Or see clustering for step KDF-hydrolase

Or see all steps for L-fucose catabolism

Or cluster curated proteins matching a keyword

Definition of KDF-hydrolase

• UniProt sequence A0A2E7P912: SubName: Full=FAA hydrolase family protein {ECO:0000313|EMBL:MBO18215.1};
• Curated sequence BPHYT_RS34210: 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-)
• Curated sequence SM_b21112: L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase
• UniProt sequence D8INW0: SubName: Full=2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway) protein {ECO:0000313|EMBL:ADJ62780.1}; EC=4.2.1.80 {ECO:0000313|EMBL:ADJ62780.1};
• Ignore hits to Q39BA7 when looking for 'other' hits (Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3)
• Curated sequence MONOMER-16233: L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (EC 1.1.1.401)
• Comment: C785_RS20550 (A0A2E7P912) was shown to be a L-2-keto-3-deoxyfuconate (L-KDF) hydrolase by PMC6336799. HSERO_RS06355 (D8INW0) is important for fucose utilization. Q39BA7 is rather closely related but is reported to be a ureidoglycolate lyase. metacyc MONOMER-16233 is misannotated as a dehydrogenase in MetaCyc -- it is the hydrolase.

Fetched 5 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 4 other characterized sequences. (Found 7 hits including self hits.)

Removing ignored items reduces this to 3 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for KDF-hydrolase.)

FAHD1_ARATH / Q93ZE5 Probable acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress)
PFams: FAA_hydrolase
223 amino acids: PaperBLAST, CDD, SwissProt::Q93ZE5
47% identical to

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD

FAHD2_ARATH / Q9LUR3 Probable acylpyruvase FAHD2, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2; FAH domain-containing protein 2; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress)
PFams: FAA_hydrolase
224 amino acids: PaperBLAST, CDD, SwissProt::Q9LUR3
43% identical to

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD

A0A076VF18 fumarylacetoacetase (EC 3.7.1.2) from Rhodotorula diobovata
PFams: FAA_hydrolase
308 amino acids: PaperBLAST, CDD, BRENDA::A0A076VF18
40% identical to

D8INW0 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway) protein; EC=4.2.1.80
281 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for KDF-hydrolase.)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD, SwissProt::Q39BA7
74% identical to

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD