Clusters of Characterized Proteins

Clustering the characterized proteins for KDF-hydrolase (2,4-diketo-3-deoxy-L-fuconate hydrolase) in L-fucose catabolism

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Definition of KDF-hydrolase

• UniProt sequence A0A2E7P912: SubName: Full=FAA hydrolase family protein {ECO:0000313|EMBL:MBO18215.1};
• Curated sequence BPHYT_RS34210: 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-)
• Curated sequence SM_b21112: L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase
• UniProt sequence D8INW0: SubName: Full=2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway) protein {ECO:0000313|EMBL:ADJ62780.1}; EC=4.2.1.80 {ECO:0000313|EMBL:ADJ62780.1};
• Ignore hits to Q39BA7 when looking for 'other' hits (Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3)
• Curated sequence MONOMER-16233: L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (EC 1.1.1.401)
• Comment: C785_RS20550 (A0A2E7P912) was shown to be a L-2-keto-3-deoxyfuconate (L-KDF) hydrolase by PMC6336799. HSERO_RS06355 (D8INW0) is important for fucose utilization. Q39BA7 is rather closely related but is reported to be a ureidoglycolate lyase. metacyc MONOMER-16233 is misannotated as a dehydrogenase in MetaCyc -- it is the hydrolase.

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 281-285 amino acids (not heteromeric)

A0A2E7P912 FAA hydrolase family protein
281 amino acids: PaperBLAST, CDD, Compare to cluster

D8INW0 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (Catechol pathway) protein; EC=4.2.1.80
281 amino acids: PaperBLAST, CDD, Compare to cluster

Q1NEI7 L-2-keto-3-deoxyrhamnonate 4-dehydrogenase subunit (EC 1.1.1.401) from Sphingomonas sp. (strain SKA58)
PFams: FAA_hydrolase
285 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
PFams: FAA_hydrolase
282 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
PFams: FAA_hydrolase
281 amino acids: PaperBLAST, CDD, Compare to cluster