Other Characterized Proteins Similar to uxuL

Finding the characterized proteins for uxuL (D-glucaro-1,5-lactonase UxuL or UxuF) in D-glucuronate catabolism

Or see clustering for step uxuL

Or see all steps for D-glucuronate catabolism

Or cluster curated proteins matching a keyword

Definition of uxuL

• UniProt sequence B2UIY8: SubName: Full=SMP-30/Gluconolaconase/LRE domain protein {ECO:0000313|EMBL:ACD29539.1};
• UniProt sequence Q888H2: SubName: Full=Senescence marker protein-30 family protein {ECO:0000313|EMBL:AAO54583.1};
• UniProt sequence A4JG52: SubName: Full=3-carboxymuconate cyclase-like protein {ECO:0000313|EMBL:ABO55255.1};
• UniProt sequence A0A0H3KPX2: SubName: Full=6-phosphogluconolactonase {ECO:0000313|EMBL:BAG44069.1}; EC=3.1.1.31 {ECO:0000313|EMBL:BAG44069.1};
• UniProt sequence Q39EM3: SubName: Full=3-carboxymuconate cyclase-like protein {ECO:0000313|EMBL:ABB09093.1};
• UniProt sequence Q881W7: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAO56265.1};
• UniProt sequence Q88NN7: SubName: Full=Gluconolactonase {ECO:0000313|EMBL:AAN66794.1}; EC=3.1.1.- {ECO:0000313|EMBL:AAN66794.1}; EC=3.1.1.17 {ECO:0000313|EMBL:AAN66794.1};
• Ignore hits to GFF3393 when looking for 'other' hits (galactaro-1,5-lactonase)
• Comment: Biochemical studies showed that lactonases uxuL and uxuF act on D-glucaro-1,5-lactone (PMC6304669). These include Rpic_4446 = B2UIY8, PSPTO_1052 = Q888H2, Bcep1808_2255 = A4JG52, BMULJ_02167 = A0A0H3KPX2, Bcep18194_A5499 = Q39EM3, and PSPTO_2765 = Q881W7, Genetic data from P. putida KT2440 shows that a uxuL-like protein (PP_1170 = Q88NN7) is involved in glucuronate utilization. UxuL/uxuF are also active on galactaro-1,5-lactone, and PS417_17365 from WCS417 may well act on both substrates, but this is not proven.

Fetched 7 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 1 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for uxuL.)

PS417_17365 galactaro-1,5-lactonase from Pseudomonas simiae WCS417
PFams: SGL
291 amino acids: PaperBLAST, CDD, reanno::WCS417:GFF3393
66% identical to

Q888H2 Senescence marker protein-30 family protein
294 amino acids: PaperBLAST, CDD