Other Characterized Proteins Similar to fumD

Finding the characterized proteins for fumD ((S)-2-methylmalate dehydratase (mesaconase)) in L-glutamate catabolism

Or see clustering for step fumD

Or see all steps for L-glutamate catabolism

Or cluster curated proteins matching a keyword

Definition of fumD

• Curated proteins or TIGRFams with EC 4.2.1.34
• Ignore hits to items matching 4.2.1.2 when looking for 'other' hits
• Comment: An enzyme from Burkholderia xenovorans was shown to have a physiologically relevant mesaconase. Many fumarases (EC 4.2.1.2) may have this activity as well, so they are marked ignore.

Fetched 3 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 3 other characterized sequences. (Found 6 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for fumD.)

Q8X999 fumarate hydratase (EC 4.2.1.2) from Escherichia coli
PFams: Fumerase, Fumerase_C
550 amino acids: PaperBLAST, CDD, BRENDA::Q8X999
68% identical to

b1612 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli K-12 substr. MG1655
P0AC33 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli (strain K12)
FUMA_ECOLI / P0AC33 Fumarate hydratase class I, aerobic; Fumarase A; Oxaloacetate keto--enol-isomerase; OAAKE isomerase; Oxaloacetate tautomerase; EC 4.2.1.2; EC 5.3.2.2 from Escherichia coli (strain K12)
P0AC33 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Escherichia coli
CH_021646 fumarate hydratase class I, aerobic; EC 4.2.1.2 from Escherichia coli K12
PFams: Fumerase, Fumerase_C
548 amino acids: PaperBLAST, CDD

FUM2_LEIMA / E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major
PFams: Fumerase, Fumerase_C
568 amino acids: PaperBLAST, CDD, SwissProt::E9AE57
64% identical to

b1612 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli K-12 substr. MG1655
P0AC33 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli (strain K12)
FUMA_ECOLI / P0AC33 Fumarate hydratase class I, aerobic; Fumarase A; Oxaloacetate keto--enol-isomerase; OAAKE isomerase; Oxaloacetate tautomerase; EC 4.2.1.2; EC 5.3.2.2 from Escherichia coli (strain K12)
P0AC33 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Escherichia coli
CH_021646 fumarate hydratase class I, aerobic; EC 4.2.1.2 from Escherichia coli K12
PFams: Fumerase, Fumerase_C
548 amino acids: PaperBLAST, CDD

FUM1_LEIMA / Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major
PFams: Fumerase, Fumerase_C
549 amino acids: PaperBLAST, CDD, SwissProt::Q4QAU9
62% identical to

b4122 fumarase B (EC 4.2.1.2; EC 4.2.1.81) from Escherichia coli K-12 substr. MG1655
P14407 fumarase B (EC 4.2.1.2; EC 4.2.1.81) from Escherichia coli (strain K12)
FUMB_ECOLI / P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12)
P14407 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Escherichia coli
GB|AAC77083.1 fumarate hydratase class I, anaerobic; EC 4.2.1.2 from Escherichia coli K12
EW|b4122 anaerobic class I fumarate hydratase (fumarase B) from Escherichia coli K12
PFams: Fumerase, Fumerase_C
548 amino acids: PaperBLAST, CDD