Other Characterized Proteins Similar to gdhA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to gdhA

Finding the characterized proteins for gdhA (glutamate dehydrogenase, NAD-dependent) in L-glutamate catabolism

Or see clustering for step gdhA

Or see all steps for L-glutamate catabolism

Or cluster curated proteins matching a keyword

Definition of gdhA

Curated proteins or TIGRFams with EC 1.4.1.2
UniProt sequence G8AE86: RecName: Full=Glutamate dehydrogenase {ECO:0000256|ARBA:ARBA00012896}; EC=1.4.1.2 {ECO:0000256|ARBA:ARBA00012896};
Ignore hits to items matching 1.4.1.3 when looking for 'other' hits
Comment: The NADP dependent enzyme acts primarily in the reverse direction, so would not contribute to catabolism. EC 1.4.1.3 describes glutamate dehydrogenases that can use either NAD or NADP; these are ignored. AZOBR_RS00190 (G8AE86) is important for proline and glutamine catabolism, and both are catabolized via glutamate; this confirms it is a glutamate dehydrogenase.

Fetched 29 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 38 other characterized sequences. (Found 66 hits including self hits.)

Removing ignored items reduces this to 17 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for gdhA.)

DHE4_PYRCJ / A3MWK6 NADP(+)-dependent glutamate dehydrogenase; NADP-GDH; EC 1.4.1.4 from Pyrobaculum calidifontis (strain JCM 11548 / VA1)
A3MWK6 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Pyrobaculum calidifontis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD, BRENDA::A3MWK6
81% identical to

DHE2_PYRCJ / A3MUY9 NAD(+)-dependent glutamate dehydrogenase; NAD-GDH; NAD-specific glutamate dehydrogenase; EC 1.4.1.2 from Pyrobaculum calidifontis (strain JCM 11548 / VA1)
A3MUY9 glutamate dehydrogenase (EC 1.4.1.2) from Pyrobaculum calidifontis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
424 amino acids: PaperBLAST, CDD

P31026 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Corynebacterium glutamicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
447 amino acids: PaperBLAST, CDD, BRENDA::P31026
54% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

P28724 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Giardia intestinalis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
449 amino acids: PaperBLAST, CDD, BRENDA::P28724
53% identical to

DHE2_CLOSY / P24295 NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Clostridium symbiosum (Bacteroides symbiosus)
P24295 glutamate dehydrogenase (EC 1.4.1.2) from Clostridium symbiosum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
450 amino acids: PaperBLAST, CDD

b1761 glutamate dehydrogenase (EC 1.4.1.4) from Escherichia coli K-12 substr. MG1655
P00370 glutamate dehydrogenase (EC 1.4.1.4) from Escherichia coli (strain K12)
DHE4_ECOLI / P00370 NADP-specific glutamate dehydrogenase; NADP-GDH; EC 1.4.1.4 from Escherichia coli (strain K12)
P00370 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Escherichia coli
PFams: ELFV_dehydrog_N, ELFV_dehydrog
447 amino acids: PaperBLAST, CDD, BRENDA::P00370
54% identical to

Q8XDW9 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Escherichia coli
PFams: ELFV_dehydrog_N, ELFV_dehydrog
447 amino acids: PaperBLAST, CDD, BRENDA::Q8XDW9
54% identical to

Q977X9 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Thermococcus waiotapuensis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
419 amino acids: PaperBLAST, CDD, BRENDA::Q977X9
53% identical to

P27346 glutamate dehydrogenase (EC 1.4.1.2) from Clostridioides difficile
GB|AAA62756.1 NAD-specific glutamate dehydrogenase; EC 1.4.1.2 from Clostridium difficile
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD

DHE4_PSYT1 / Q9S1F9 NADP-specific glutamate dehydrogenase; NADP-GDH; EC 1.4.1.4 from Psychrobacter sp. (strain TAD1)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
448 amino acids: PaperBLAST, CDD, SwissProt::Q9S1F9
52% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

Q8ILF7 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Plasmodium falciparum
PFams: ELFV_dehydrog_N, ELFV_dehydrog, NAD_binding_7
510 amino acids: PaperBLAST, CDD, BRENDA::Q8ILF7
52% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

A0R3E3 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Mycolicibacterium smegmatis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
449 amino acids: PaperBLAST, CDD, BRENDA::A0R3E3
51% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

P18819 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Aspergillus nidulans
CH_122285 NADP-specific glutamate dehydrogenase (NADP-GDH); EC 1.4.1.4 from Emericella nidulans
PFams: ELFV_dehydrog_N, ELFV_dehydrog
459 amino acids: PaperBLAST, CDD, BRENDA::P18819
51% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

P00369 glutamate dehydrogenase subunit (EC 1.4.1.4) from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
454 amino acids: PaperBLAST, CDD, metacyc::MONOMER-13461
51% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

B6V7E4 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Aspergillus niger
PFams: ELFV_dehydrog_N, ELFV_dehydrog
460 amino acids: PaperBLAST, CDD, BRENDA::B6V7E4
50% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

Q8ILT0 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Plasmodium falciparum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
470 amino acids: PaperBLAST, CDD, BRENDA::Q8ILT0
50% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

Q9YC65 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Aeropyrum pernix
PFams: ELFV_dehydrog_N, ELFV_dehydrog
418 amino acids: PaperBLAST, CDD, BRENDA::Q9YC65
49% identical to

Q9Y8I4 glutamate dehydrogenase (EC 1.4.1.2) from Pyrobaculum islandicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD

C6EVR5 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Xanthophyllomyces dendrorhous
PFams: ELFV_dehydrog_N, ELFV_dehydrog
455 amino acids: PaperBLAST, CDD, BRENDA::C6EVR5
50% identical to

DHE4_YEAST / P07262 NADP-specific glutamate dehydrogenase 1; NADP-GDH 1; NADP-dependent glutamate dehydrogenase 1; EC 1.4.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P07262 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Saccharomyces cerevisiae
PFams: ELFV_dehydrog_N, ELFV_dehydrog
454 amino acids: PaperBLAST, CDD, BRENDA::P07262
49% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

DHE4_HALSI / Q5MBG2 NADP-specific glutamate dehydrogenase A1; EC 1.4.1.4 from Halobacterium salinarum (Halobacterium halobium)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
417 amino acids: PaperBLAST, CDD, SwissProt::Q5MBG2
49% identical to

P29051 GdhA (EC 1.4.1.4) from Halobacterium salinarum
DHE2_HALSI / P29051 NAD-specific glutamate dehydrogenase A; NAD-GDH A; EC 1.4.1.2 from Halobacterium salinarum (Halobacterium halobium)
P29051 glutamate dehydrogenase (EC 1.4.1.2) from Halobacterium salinarum
GB|AAW19068.1 glutamate dehydrogenase; EC 1.4.1.2 from Halobacterium salinarum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
435 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for gdhA.)

P00367 Glutamate dehydrogenase 1, mitochondrial (EC 1.4.1.3) from Homo sapiens
DHE3_HUMAN / P00367 Glutamate dehydrogenase 1, mitochondrial; GDH 1; EC 1.4.1.3 from Homo sapiens (Human)
P00367 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Homo sapiens
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD, BRENDA::P00367
97% identical to

DHE3_BOVIN / P00366 Glutamate dehydrogenase 1, mitochondrial; GDH 1; EC 1.4.1.3 from Bos taurus (Bovine)
P00366 glutamate dehydrogenase (EC 1.4.1.2) from Bos taurus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD

DHE3_MOUSE / P26443 Glutamate dehydrogenase 1, mitochondrial; GDH 1; EC 1.4.1.3 from Mus musculus (Mouse)
P26443 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Mus musculus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD, BRENDA::P26443
97% identical to

DHE3_RAT / P10860 Glutamate dehydrogenase 1, mitochondrial; GDH 1; Memory-related gene 2 protein; MRG-2; EC 1.4.1.3 from Rattus norvegicus (Rat)
P10860 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Rattus norvegicus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD, BRENDA::P10860
96% identical to

P49448 Glutamate dehydrogenase 2, mitochondrial (EC 1.4.1.3) from Homo sapiens
DHE4_HUMAN / P49448 Glutamate dehydrogenase 2, mitochondrial; GDH 2; EC 1.4.1.3 from Homo sapiens (Human)
P49448 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Homo sapiens
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD, BRENDA::P49448
93% identical to

Q9LEC8 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Nicotiana plumbaginifolia
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, BRENDA::Q9LEC8
90% identical to

P93541 glutamate dehydrogenase (EC 1.4.1.3) from Solanum lycopersicum
P93541 glutamate dehydrogenase (EC 1.4.1.2) from Solanum lycopersicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
412 amino acids: PaperBLAST, CDD

Q43314 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Arabidopsis thaliana
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, BRENDA::Q43314
88% identical to

O04937 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Nicotiana plumbaginifolia
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, BRENDA::O04937
87% identical to

Q38946 glutamate dehydrogenase β subunit (EC 1.4.1.2) from Arabidopsis thaliana
DHE2_ARATH / Q38946 Glutamate dehydrogenase 2; GDH 2; EC 1.4.1.3 from Arabidopsis thaliana (Mouse-ear cress)
Q38946 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Arabidopsis thaliana
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD

Q9S7A0 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Arabidopsis thaliana
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, BRENDA::Q9S7A0
86% identical to

Q5QDM6 glutamate dehydrogenase (EC 1.4.1.2) from Lupinus luteus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD

DHE2_ORYSJ / Q33E23 Glutamate dehydrogenase 2, mitochondrial; OsGDH2; EC 1.4.1.3 from Oryza sativa subsp. japonica (Rice)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, SwissProt::Q33E23
83% identical to

DHE3_ORYSJ / Q6H3Y7 Glutamate dehydrogenase 3, mitochondrial; OsGDH3; EC 1.4.1.3 from Oryza sativa subsp. japonica (Rice)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, SwissProt::Q6H3Y7
81% identical to

DHE3_DROME / P54385 Glutamate dehydrogenase, mitochondrial; GDH; EC 1.4.1.3 from Drosophila melanogaster (Fruit fly)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
562 amino acids: PaperBLAST, CDD, SwissProt::P54385
70% identical to

DHE4_PRERU / P95544 NAD(P)-specific glutamate dehydrogenase; NAD(P)-GDH; NAD(P)H-dependent glutamate dehydrogenase; EC 1.4.1.3 from Prevotella ruminicola (Bacteroides ruminicola)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
444 amino acids: PaperBLAST, CDD, SwissProt::P95544
56% identical to

A0A1V1FMC4 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Streptococcus equinus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
449 amino acids: PaperBLAST, CDD, BRENDA::A0A1V1FMC4
54% identical to

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD

O74024 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Thermococcus profundus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
419 amino acids: PaperBLAST, CDD, BRENDA::O74024
53% identical to

P80319 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Pyrococcus furiosus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
420 amino acids: PaperBLAST, CDD, BRENDA::P80319
53% identical to

GUDB_BACSU / P50735 Cryptic catabolic NAD-specific glutamate dehydrogenase GudB; NAD-GDH; EC 1.4.1.2 from Bacillus subtilis (strain 168)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
427 amino acids: PaperBLAST, CDD

GB|AAA64795.1 glutamate dehydrogenase (NAD(P)(+)); EC 1.4.1.3 from Pyrococcus endeavori
PFams: ELFV_dehydrog_N, ELFV_dehydrog
420 amino acids: PaperBLAST, CDD, CharProtDB::CH_015456
52% identical to

P96110 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Thermotoga maritima
CH_015463 glutamate dehydrogenase; EC 1.4.1.3 from Thermotoga maritima
PFams: ELFV_dehydrog_N, ELFV_dehydrog
416 amino acids: PaperBLAST, CDD, CharProtDB::CH_015463
51% identical to

DHE3_THELN / Q56304 Glutamate dehydrogenase; GDH; EC 1.4.1.3 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Q56304 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3); glutamate dehydrogenase (NADP+) (EC 1.4.1.4) from Thermococcus litoralis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
419 amino acids: PaperBLAST, CDD, SwissProt::Q56304
51% identical to

O59650 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Thermococcus kodakarensis
CH_015459 glutamate dehydrogenase (NAD(P)(+)); EC 1.4.1.3 from Thermococcus kodakarensis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD, BRENDA::O59650
50% identical to

P80053 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Saccharolobus solfataricus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
420 amino acids: PaperBLAST, CDD, BRENDA::P80053
46% identical to

Q9Y8I4 glutamate dehydrogenase (EC 1.4.1.2) from Pyrobaculum islandicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD

DHE3_DICDI / Q54KB7 Glutamate dehydrogenase, mitochondrial; GDH; EC 1.4.1.3 from Dictyostelium discoideum (Slime mold)
PFams: ELFV_dehydrog_N, ELFV_dehydrog, AdoHcyase_NAD
502 amino acids: PaperBLAST, CDD, SwissProt::Q54KB7
48% identical to