Clusters of Characterized Proteins

Clustering the characterized proteins for dhaK (dihydroxyacetone:PEP phosphotransferase, subunit K) in glycerol catabolism

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Definition of dhaK

• Curated sequence P76015: glycerone kinase (EC 2.7.1.29). dihydroxyacetone kinase, DhaK subunit; EC 2.7.-.-. PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121. dihydroxyacetone kinase subunit K (EC 2.7.1.121). dihydroxyacetone kinase subunit K
• Curated sequence Q92EU2: PTS-dependent dihydroxyacetone kinase 2, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121
• Curated sequence Q9CIV8: PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121
• Ignore hits to items matching 2.7.1.121 when looking for 'other' hits
• Ignore hits to A0A1D3TV19 when looking for 'other' hits (glycerone kinase (EC 2.7.1.29))
• Comment: most prokaryotic dihydroxyacetone kinases are heteromeric and use phosophoenolpyruvate rather than ATP as the phosphoryl donor (EC 2.7.1.121) This is a PTS-like system that relies on EI and Hpr proteins to phosphorylate the dhaM subunit The BRENDA entry does not actually seem to be characterized, not clear if it is dhaK or dhaK'

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 331-356 amino acids (not heteromeric)

b1200 dihydroxyacetone kinase subunit K (EC 2.7.1.121) from Escherichia coli K-12 substr. MG1655
P76015 dihydroxyacetone kinase subunit K from Escherichia coli (strain K12)
DHAK_ECOLI / P76015 PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121 from Escherichia coli (strain K12)
P76015 glycerone kinase (EC 2.7.1.29) from Escherichia coli
CH_088626 dihydroxyacetone kinase, DhaK subunit; EC 2.7.-.- from Escherichia coli K12
PFams: Dak1
356 amino acids: PaperBLAST, CDD, Compare to cluster

DHAK2_LISIN / Q92EU2 PTS-dependent dihydroxyacetone kinase 2, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121 from Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
PFams: Dak1
331 amino acids: PaperBLAST, CDD, Compare to cluster

DHAK_LACLA / Q9CIV8 PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK; EC 2.7.1.121 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
PFams: Dak1
332 amino acids: PaperBLAST, CDD, Compare to cluster