GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for SLC38A3 (L-histidine:Na+ symporter) in L-histidine catabolism

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Definition of SLC38A3

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 504-505 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

S38A3_HUMAN / Q99624 Sodium-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1 from Homo sapiens (Human)
TC 2.A.18.6.3 / Q99624 System N1, SNAT3 [glutamine/histidine/asparagine/alanine]:[Na+ + H+] sym/antiporter (1 aa + 2 Na+ cotransported against 1 H+ antiported out) (probable orthologue of mNAT). Li+ can substitute for Na+; system N1 can function bidirectionally. SNAT3 is a primarily a glutamine transporter required for amino acid homeostasis. Loss cannot be compensated, suggesting that this transporter is a major route of glutamine transport in the liver, brain, and kidney from Homo sapiens (Human)
RF|NP_006832.1 sodium-coupled neutral amino acid transporter 3 from Homo sapiens
PFams: Aa_trans
504 amino acids: PaperBLAST, CDD, Compare to cluster

S38A3_MOUSE / Q9DCP2 Sodium-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; mNAT; System N amino acid transporter 1 from Mus musculus (Mouse)
TC 2.A.18.6.2 / Q9DCP2 Liver histidine and glutamine specific system N-like, Na+-dependent amino acid transporter, mNAT. Also called SNAT3. SNAT3 trafficking occurs in a dynamin-independent manner and is influenced by caveolin
RF|NP_076294.2 sodium-coupled neutral amino acid transporter 3 from Mus musculus
PFams: Aa_trans
505 amino acids: PaperBLAST, CDD, Compare to cluster