Other Characterized Proteins Similar to acdH

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to acdH

Finding the characterized proteins for acdH ((2S)-2-methylbutanoyl-CoA dehydrogenase) in L-isoleucine catabolism

Or see clustering for step acdH

Or see all steps for L-isoleucine catabolism

Or cluster curated proteins matching a keyword

Definition of acdH

Curated proteins or TIGRFams with EC 1.3.8.5
Curated sequence PfGW456L13_2983: Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1)
Curated sequence 7025618: Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)
Curated sequence MONOMER-17424: short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1)
Ignore hits to GFF2392 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.1))
Ignore hits to GFF2713 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to PfGW456L13_2985 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to AO353_25670 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
Ignore hits to P45857 when looking for 'other' hits (Acyl-CoA dehydrogenase; EC 1.3.99.-)
Ignore hits to CH_091788 when looking for 'other' hits (acyl-CoA dehydrogenase)
Comment: EC 1.3.8.5 includes (2S)-2-methylbutanoyl-CoA dehydrogenases and also isobutyryl-CoA dehydrogenases (involved in valine degradation) or sometimes 3-methylbutanoyl-CoA dehydrogenases (involved in leucine degradation, usually given EC 1.3.8.4). Some enzymes act on all three methylacyl-CoA substrates. Other genes are required only for valine degradation and their activity on 2-methylbutanoyl-CoA uncertain, so they are marked ignore. PfGW456L13_2983 and Shewana3_2769 (VIMSS 7025618) and PP_2216 (MONOMER-17424) were annotated with other EC numbers (implying other acyl-CoA substrates) but are involved in isoleucine utilization, so are included. Various isobutyryl-CoA dehydrogenases are ignored (they may well act on 2-methylbutanoyl-CoA as well). P45857 (mmgC from B. subtilis) is part of an operon with methylcitrate cycle genes, and could be involved in isoleucine catabolism, but its biochemical activity is uncertain, so it is ignored, as is the nearly-identical CH_091788.

Fetched 14 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 30 other characterized sequences. (Found 44 hits including self hits.)

Removing ignored items reduces this to 24 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for acdH.)

ACAD8_HUMAN / Q9UKU7 Isobutyryl-CoA dehydrogenase, mitochondrial; IBDH; Activator-recruited cofactor 42 kDa component; ARC42; Acyl-CoA dehydrogenase family member 8; ACAD-8; EC 1.3.8.- from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
415 amino acids: PaperBLAST, CDD, SwissProt::Q9UKU7
55% identical to

Shewana3_2769 Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) from Shewanella sp. ANA-3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
385 amino acids: PaperBLAST, CDD

ACDA_BACSU / P45867 Acyl-CoA dehydrogenase; EC 1.3.99.- from Bacillus subtilis (strain 168)
GB|CAA89868.1 acyl-CoA dehydrogenase; EC 1.3.99.3 from Bacillus subtilis
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD, SwissProt::P45867
50% identical to

Pf6N2E2_1146 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

D9TQ00 butanal dehydrogenase (EC 1.2.1.57) from Thermoanaerobacterium saccharolyticum
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
380 amino acids: PaperBLAST, CDD, BRENDA::D9TQ00
49% identical to

ACADS_RAT / P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
412 amino acids: PaperBLAST, CDD, SwissProt::P15651
47% identical to

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

ACADS_BOVIN / Q3ZBF6 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Bos taurus (Bovine)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
412 amino acids: PaperBLAST, CDD, SwissProt::Q3ZBF6
47% identical to

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

D2RL84 butanoyl-CoA dehydrogenase (NAD+, ferredoxin) (subunit 1/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (subunit 1/2) (EC 1.3.8.1) from Acidaminococcus fermentans
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
Heteromeric, 383 amino acids: PaperBLAST, CDD, BRENDA::D2RL84
48% identical to

P16219 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Homo sapiens
ACADS_HUMAN / P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
412 amino acids: PaperBLAST, CDD, SwissProt::P16219
47% identical to

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

CH_122582 acyl-CoA dehydrogenase, putative (AFU_orthologue; AFUA_1G14850) from Emericella nidulans
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
437 amino acids: PaperBLAST, CDD, CharProtDB::CH_122582
50% identical to

ACDSB_HUMAN / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
432 amino acids: PaperBLAST, CDD

D4QEZ8 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Homo sapiens
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
412 amino acids: PaperBLAST, CDD, BRENDA::D4QEZ8
47% identical to

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

Q18AQ1 butanoyl-CoA dehydrogenase (NAD+, ferredoxin) (subunit 3/3) (EC 1.3.1.109); short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Clostridioides difficile
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
Heteromeric, 378 amino acids: PaperBLAST, CDD, BRENDA::Q18AQ1
47% identical to

A5N5C8 butyryl-CoA dehydrogenase (EC 1.3.8.1) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD, metacyc::MONOMER-13470
47% identical to

G3KIM8 propionyl-CoA dehydrogenase from Anaerotignum propionicum
ACRC_ANAPI / G3KIM8 Acryloyl-CoA reductase (NADH); Propionyl-CoA dehydrogenase; EC 1.3.1.95 from Anaerotignum propionicum (Clostridium propionicum)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
Heteromeric, 394 amino acids: PaperBLAST, CDD, SwissProt::G3KIM8
47% identical to

CARC_ACEWD / H6LGM6 Caffeyl-CoA reductase-Etf complex subunit CarC; Caffeoyl-CoA reductase CarC; NADH-dependent caffeyl-CoA reduction; EC 1.3.1.108 from Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)
H6LGM6 caffeoyl-CoA reductase (subunit 3/3) (EC 1.3.1.108) from Acetobacterium woodii
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
Heteromeric, 379 amino acids: PaperBLAST, CDD, SwissProt::H6LGM6
46% identical to

PfGW456L13_2983 Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Pseudomonas fluorescens GW456-L13
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

J7TF92 cinnamate reductase monomer from Clostridium sporogenes (strain ATCC 15579)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
377 amino acids: PaperBLAST, CDD, metacyc::MONOMER-20595
46% identical to

P52042 butyryl-CoA dehydrogenase (EC 1.3.8.1) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
ACDS_CLOAB / P52042 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; SCAD; EC 1.3.8.1 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
CH_091785 butyryl-CoA dehydrogenase; EC 1.3.99.2 from Clostridium acetobutylicum
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD, CharProtDB::CH_091785
45% identical to

Q06319 butyryl-CoA dehydrogenase subunit (EC 1.3.8.1) from Megasphaera elsdenii
GI|149886 butyryl-CoA dehydrogenase; EC 1.3.99.2 from Megasphaera elsdenii
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, CharProtDB::CH_091787
45% identical to

Q39QF5 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase (EC 1.3.8.10) from Geobacter metallireducens
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
380 amino acids: PaperBLAST, CDD, BRENDA::Q39QF5
41% identical to

Q2LQN9 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase monomer (EC 1.3.7.8; EC 1.3.8.10) from Syntrophus aciditrophicus (strain SB)
CH1CO_SYNAS / Q2LQN9 Cyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Ch1CoA; EC 1.3.8.10 from Syntrophus aciditrophicus (strain SB)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
414 amino acids: PaperBLAST, CDD, SwissProt::Q2LQN9
41% identical to

PGA1_c10280 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Phaeobacter inhibens BS107
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
386 amino acids: PaperBLAST, CDD, reanno::Phaeo:GFF1011
41% identical to

AO356_26355 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2C3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

MBCD_SOLTU / Q9FS88 2-methylacyl-CoA dehydrogenase, mitochondrial; 2-methylbutanoyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2MBCD; Isovaleryl-CoA dehydrogenase 1; St-IVD1; EC 1.3.99.12 from Solanum tuberosum (Potato)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
412 amino acids: PaperBLAST, CDD, SwissProt::Q9FS88
40% identical to

Pf1N1B4_4787 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N1B4
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

SM_b21121 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) from Sinorhizobium meliloti 1021
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
387 amino acids: PaperBLAST, CDD, reanno::Smeli:SM_b21121
41% identical to

Q65Y10 short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Butyrivibrio fibrisolvens
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
387 amino acids: PaperBLAST, CDD, BRENDA::Q65Y10
40% identical to

P11310 mitochondrial medium-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.7) from Homo sapiens
ACADM_HUMAN / P11310 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; EC 1.3.8.7 from Homo sapiens (Human)
P11310 medium-chain acyl-CoA dehydrogenase (EC 1.3.8.7) from Homo sapiens
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
421 amino acids: PaperBLAST, CDD, BRENDA::P11310
40% identical to

ACAD9_HUMAN / Q9H845 Complex I assembly factor ACAD9, mitochondrial; Acyl-CoA dehydrogenase family member 9; ACAD-9; EC 1.3.8.- from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
621 amino acids: PaperBLAST, CDD, SwissProt::Q9H845
40% identical to

Q88KS3 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for acdH.)

PS417_13840 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, reanno::WCS417:GFF2713
59% identical to

AO353_25670 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_25670
60% identical to

Psest_2445 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD

PfGW456L13_2985 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens GW456-L13
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, reanno::pseudo13_GW456_L13:PfGW456L13_2985
59% identical to

Psest_2445 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD

Psest_2440 isobutyryl-CoA dehydrogenase (EC 1.3.8.1) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
383 amino acids: PaperBLAST, CDD, reanno::psRCH2:GFF2392
59% identical to

Psest_2445 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD

ACDB_BACSU / P45857 Acyl-CoA dehydrogenase; EC 1.3.99.- from Bacillus subtilis (strain 168)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD, SwissProt::P45857
50% identical to

GI|1303933 acyl-CoA dehydrogenase from Bacillus subtilis
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
378 amino acids: PaperBLAST, CDD, CharProtDB::CH_091788
50% identical to