GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for mcmA (methylmalonyl-CoA mutase, fused catalytic and adenosylcobamide-binding components) in L-isoleucine catabolism

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Definition of mcmA

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 709-750 amino acids (not heteromeric)

MUTA_HUMAN / P22033 Methylmalonyl-CoA mutase, mitochondrial; MCM; Methylmalonyl-CoA isomerase; EC 5.4.99.2 from Homo sapiens (Human)
P22033 methylmalonyl-CoA mutase (EC 5.4.99.2) from Homo sapiens
P22033 Methylmalonyl-CoA mutase, mitochondrial (EC 5.4.99.2) from Homo sapiens
PFams: MM_CoA_mutase, B12-binding
750 amino acids: PaperBLAST, CDD, Compare to cluster

Q23381 methylmalonyl-CoA mutase (EC 5.4.99.2) from Caenorhabditis elegans
PFams: MM_CoA_mutase, B12-binding
744 amino acids: PaperBLAST, CDD, Compare to cluster

Q84FZ1 methylmalonyl-CoA mutase (EC 5.4.99.2) from Methylorubrum extorquens
PFams: MM_CoA_mutase, B12-binding
721 amino acids: PaperBLAST, CDD, Compare to cluster

Q8MI68 methylmalonyl-CoA mutase (EC 5.4.99.2) from Sus scrofa
PFams: MM_CoA_mutase, B12-binding
750 amino acids: PaperBLAST, CDD, Compare to cluster

MCM_RHIME / O86028 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
PFams: MM_CoA_mutase, B12-binding
712 amino acids: PaperBLAST, CDD, Compare to cluster

b2917 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli K-12 substr. MG1655
SCPA_ECOLI / P27253 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Escherichia coli (strain K12)
P27253 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli (strain K12)
PFams: MM_CoA_mutase, B12-binding
714 amino acids: PaperBLAST, CDD, Compare to cluster

MCM_RHOS4 / Q3J4D7 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Q3J4D7 methylmalonyl-CoA mutase (EC 5.4.99.2) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
PFams: MM_CoA_mutase, B12-binding
709 amino acids: PaperBLAST, CDD, Compare to cluster

F1KUP0 methylmalonyl-CoA mutase subunit (EC 5.4.99.2) from Ascaris suum
PFams: MM_CoA_mutase, B12-binding
748 amino acids: PaperBLAST, CDD, Compare to cluster

Dsui_0519 Methylmalonyl-CoA mutase (EC 5.4.99.2) from Dechlorosoma suillum PS
PFams: MM_CoA_mutase, B12-binding
721 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 1099-1125 amino acids (not heteromeric)

Q8F222 methylmalonyl-CoA mutase (EC 5.4.99.2) from Leptospira interrogans serovar lai str. 56601
PFams: B12-binding, MeaB, cobW, MM_CoA_mutase
1125 amino acids: PaperBLAST, CDD, Compare to cluster

Q8Y2U5 methylmalonyl-CoA mutase (EC 5.4.99.2) from Ralstonia solanacearum
PFams: B12-binding, MeaB, cobW, MM_CoA_mutase
1099 amino acids: PaperBLAST, CDD, Compare to cluster