Other Characterized Proteins Similar to manX
Finding the characterized proteins for manX (glucose PTS, enzyme EIIAB) in lactose catabolism
Or see clustering for step manX
Or see all steps for lactose catabolism
Or cluster curated proteins matching a keyword
Definition of manX
- Curated sequence CH_088329: PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191. PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIAB component
- Curated sequence E1UCI0: PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN
- Curated sequence Q04GK1: Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system
- Curated sequence Q2QKM4: ManL aka EIIAB, component of Glucose porter, ManLMN
- Curated sequence Q5M5W6: ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
- Ignore hits to Q9S4L5 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
- Ignore hits to D2BKY7 when looking for 'other' hits (Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine)
- Comment: PTS system manXYZ (manX is EIIAB; manY is EIIC; manZ is EIID) from E. coli, Listeria, Oenococcus, Lactobacillus, and Streptococcus. Systems related to manXYZ in Streptococcus salivarius and Lactococcus lactis subsp. lactis are reported to act on glucose, but are listed with other preferred substrates; ignore these.
Fetched 5 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 2 other characterized sequences. (Found 7 hits including self hits.)
Removing ignored items reduces this to 0 close sequences.
Close but ignored sequences
(Sequences that are similar to these will still be high-confidence candidates for manX.)
Q9S4L5 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Streptococcus salivarius
PFams: EIIA-man, PTSIIB_sorb
330 amino acids: PaperBLAST, CDD, BRENDA::Q9S4L5
96% identical to
TC 4.A.6.1.7 / Q5M5W6 ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 330 amino acids: PaperBLAST, CDD
TC 4.A.6.1.11 / D2BKY7 Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 329 amino acids: PaperBLAST, CDD, TCDB::D2BKY7
76% identical to
TC 4.A.6.1.7 / Q5M5W6 ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 330 amino acids: PaperBLAST, CDD