Other Characterized Proteins Similar to ilvE

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to ilvE

Finding the characterized proteins for ilvE (L-leucine transaminase) in L-leucine catabolism

Or see clustering for step ilvE

Or see all steps for L-leucine catabolism

Or cluster curated proteins matching a keyword

Definition of ilvE

Curated proteins or TIGRFams with EC 2.6.1.6
Curated proteins or TIGRFams with EC 2.6.1.42
Comment: These enzymes transfer the amino group to 2-oxoglutarate to form glutamate; glutamate dehydrogenase (not included in the pathway definition) can then release the ammonia. Many other paths are possible but do not seem to be known (i.e., transfer to oxaloacetate followed by aspartate-ammonia lyase).

Fetched 48 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 36 other characterized sequences. (Found 84 hits including self hits.)

There are also 1 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for ilvE.)

ARAT1_THELN / H3ZPL1 Aromatic-amino-acid aminotransferase 1; ARAT-I; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
PFams: Aminotran_1_2, Aminotran_MocR
417 amino acids: PaperBLAST, CDD, SwissProt::H3ZPL1
94% identical to

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Aminotran_MocR
417 amino acids: PaperBLAST, CDD

O85746 tyrosine aminotransferase monomer (EC 2.6.1.88) from Klebsiella pneumoniae
TYRB_KLEPN / O85746 Tyrosine aminotransferase; TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase; EC 2.6.1.5; EC 2.6.1.57; EC 2.6.1.1 from Klebsiella pneumoniae
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, SwissProt::O85746
83% identical to

b4054 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.42; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.1) from Escherichia coli K-12 substr. MG1655
P04693 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.27; EC 2.6.1.1) from Escherichia coli (strain K12)
TYRB_ECOLI / P04693 Aromatic-amino-acid aminotransferase; ARAT; AROAT; Beta-methylphenylalanine transaminase; EC 2.6.1.57; EC 2.6.1.107 from Escherichia coli (strain K12)
GB|AAC77024.1 aromatic-amino-acid transaminase TyrB; EC 2.6.1.57 from Escherichia coli K12
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD

O57946 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Pyrococcus horikoshii
PFams: Aminotran_1_2, Aminotran_MocR
428 amino acids: PaperBLAST, CDD, BRENDA::O57946
75% identical to

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Aminotran_MocR
417 amino acids: PaperBLAST, CDD

TAR1_ARATH / Q9LR29 Tryptophan aminotransferase-related protein 1; EC 2.6.1.27; EC 2.6.1.99 from Arabidopsis thaliana (Mouse-ear cress)
Q9LR29 tryptophan transaminase (EC 2.6.1.27) from Arabidopsis thaliana
PFams: Alliinase_C, Aminotran_1_2
388 amino acids: PaperBLAST, CDD, BRENDA::Q9LR29
68% identical to

Q9S7N2 tryptophan aminotransferase (EC 2.6.1.1; EC 2.6.1.58; EC 2.6.1.2; EC 2.6.1.6; EC 2.6.1.27; EC 2.6.1.99) from Arabidopsis thaliana
TAA1_ARATH / Q9S7N2 L-tryptophan--pyruvate aminotransferase 1; Protein CYTOKININ INDUCED ROOT CURLING 1; Protein SHADE AVOIDANCE 3; Protein TRANSPORT INHIBITOR RESPONSE 2; Protein TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS 1; Protein WEAK ETHYLENE INSENSITIVE 8; Tryptophan transaminase; EC 2.6.1.27; EC 2.6.1.99 from Arabidopsis thaliana (Mouse-ear cress)
Q9S7N2 tryptophan transaminase (EC 2.6.1.27); L-tryptophan-pyruvate aminotransferase (EC 2.6.1.99) from Arabidopsis thaliana
PFams: Alliinase_C, Aminotran_1_2
391 amino acids: PaperBLAST, CDD

HTYB_ASPRU / K0E3V3 Transaminase htyB; L-homotyrosine biosynthetic cluster protein B; EC 2.6.1.- from Aspergillus rugulosus (Emericella rugulosa)
PFams: Aminotran_4
379 amino acids: PaperBLAST, CDD, SwissProt::K0E3V3
64% identical to

GLOG_GLAL2 / S3DQP8 Branched-chain amino acid aminotransferase gloG; L-homotyrosine biosynthesis sub-cluster protein gloG; Pneumocandin biosynthesis cluster protein G; EC 2.6.1.42 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD

APF4_GIBF5 / S0DS11 Aminotransferase apf4; Apicidin F synthesis protein 4; EC 2.6.1.- from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
PFams: Aminotran_4
378 amino acids: PaperBLAST, CDD, SwissProt::S0DS11
60% identical to

TOXF_COCCA / Q9Y885 Putative branched-chain-amino-acid aminotransferase TOXF; EC 2.6.1.42 from Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)
PFams: Aminotran_4
357 amino acids: PaperBLAST, CDD

RR42_RS33490 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Cupriavidus basilensis 4G11
PFams: Aminotran_1_2
400 amino acids: PaperBLAST, CDD, reanno::Cup4G11:RR42_RS33490
57% identical to

AMT5_ALTAL / C9K7B6 Transaminase AMT5; AM-toxin biosynthesis protein 5; EC 2.6.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aminotran_4
373 amino acids: PaperBLAST, CDD, SwissProt::C9K7B6
55% identical to

AMT52_ALTAL / C9K7D8 Transaminase AMT5-2; AM-toxin biosynthesis protein 5-2; EC 2.6.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aminotran_4
373 amino acids: PaperBLAST, CDD, SwissProt::C9K7D8
54% identical to

TAR2_ARATH / Q94A02 Tryptophan aminotransferase-related protein 2; EC 2.6.1.27; EC 2.6.1.99 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Alliinase_C, Aminotran_1_2
440 amino acids: PaperBLAST, CDD, SwissProt::Q94A02
51% identical to

F2FB37 tryptophan transaminase (EC 2.6.1.27) from Zea mays
PFams: Alliinase_C, Aminotran_1_2
530 amino acids: PaperBLAST, CDD, BRENDA::F2FB37
51% identical to

LCSP_PURLI / A0A179HME7 Aminotransferase lcsP; Leucinostatins biosynthesis cluster protein P; EC 2.6.1.- from Purpureocillium lilacinum (Paecilomyces lilacinus)
PFams: Aminotran_4
387 amino acids: PaperBLAST, CDD, SwissProt::A0A179HME7
48% identical to

TAR2_ORYSJ / Q5VQG8 Tryptophan aminotransferase-related protein 2; OsTAR2; Protein FISH BONE; EC 2.6.1.27 from Oryza sativa subsp. japonica (Rice)
PFams: Alliinase_C, Aminotran_1_2
507 amino acids: PaperBLAST, CDD, SwissProt::Q5VQG8
49% identical to

TAR1_ORYSJ / Q0DKE8 Tryptophan aminotransferase-related protein 1; OsTAR1; Protein FISH BONE-LIKE; Protein FIB-LIKE; EC 2.6.1.27 from Oryza sativa subsp. japonica (Rice)
PFams: Alliinase_C, Aminotran_1_2
441 amino acids: PaperBLAST, CDD, SwissProt::Q0DKE8
48% identical to

ATNJ_EMENI / Q5AV04 Aminotransferase atnJ; Aspercryptin biosynthesis cluster protein J; EC 2.6.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
348 amino acids: PaperBLAST, CDD, SwissProt::Q5AV04
49% identical to

P43336 tyrosine aminotransferase subunit (EC 2.6.1.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Aminotran_1_2
399 amino acids: PaperBLAST, CDD, metacyc::MONOMER-12023
45% identical to

B4FQ44 L-tryptophan:pyruvate aminotransferase (EC 2.6.1.99) from Zea mays
PFams: Alliinase_C, Aminotran_1_2
431 amino acids: PaperBLAST, CDD, metacyc::GDQC-105657-MONOMER
48% identical to

Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
PFams: Aminotran_1_2, Aminotran_MocR
397 amino acids: PaperBLAST, CDD, metacyc::MONOMER-6727
45% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Aminotran_MocR
401 amino acids: PaperBLAST, CDD

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus
PFams: Aminotran_1_2, Aminotran_MocR
397 amino acids: PaperBLAST, CDD, BRENDA::Q72LL6
45% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Aminotran_MocR
401 amino acids: PaperBLAST, CDD

AO353_18575 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens FW300-N2E3
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_18575
43% identical to

Psest_0779 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas stutzeri RCH2
PFams: Aminotran_1_2
398 amino acids: PaperBLAST, CDD, reanno::psRCH2:GFF765
43% identical to

PfGW456L13_4396 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens GW456-L13
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo13_GW456_L13:PfGW456L13_4396
42% identical to

b0928 aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.57; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.7; EC 2.6.1.3) from Escherichia coli K-12 substr. MG1655
P00509 aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.27; EC 2.6.1.7; EC 2.6.1.3) from Escherichia coli (strain K12)
AAT_ECOLI / P00509 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Escherichia coli (strain K12)
A0A140ND68 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
D3H0F7 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
P00509 aspartate transaminase (EC 2.6.1.1) from Escherichia coli
PFams: Aminotran_1_2
396 amino acids: PaperBLAST, CDD, BRENDA::A0A140ND68
42% identical to

AO356_03985 Aspartate aminotransferase (EC 2.6.1.1) from Pseudomonas fluorescens FW300-N2C3
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_03985
42% identical to

Pf6N2E2_2632 tyrosine aminotransferase (EC 2.6.1.57) from Pseudomonas fluorescens FW300-N2E2
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::pseudo6_N2E2:Pf6N2E2_2632
42% identical to

HP15_858 phenylalanine aminotransferase (EC 2.6.1.57) from Marinobacter adhaerens HP15
PFams: Aminotran_1_2
395 amino acids: PaperBLAST, CDD, reanno::Marino:GFF879
41% identical to

AAT5_ARATH / P46248 Aspartate aminotransferase, chloroplastic; Transaminase A; EC 2.6.1.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_1_2
453 amino acids: PaperBLAST, CDD, SwissProt::P46248
41% identical to

AATM_MOUSE / P05202 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Mus musculus (Mouse)
P05202 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P05202
42% identical to

P00507 mitochondrial aspartate aminotransferase subunit (EC 2.6.1.1) from Rattus norvegicus
AATM_RAT / P00507 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Rattus norvegicus (Rat)
P00507 aspartate transaminase (EC 2.6.1.1) from Rattus norvegicus
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P00507
41% identical to

P00505 Aspartate aminotransferase, mitochondrial (EC 2.6.1.23; EC 2.6.1.1; EC 2.6.1.7) from Homo sapiens
AATM_HUMAN / P00505 Aspartate aminotransferase, mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Homo sapiens (Human)
P00505 aspartate transaminase (EC 2.6.1.1) from Homo sapiens
TC 9.A.70.1.1 / P00505 Mitochondrial aspartate amino transferase of 430 aas and 1 TMS, AAT or GOT2 from Homo sapiens
PFams: Aminotran_1_2
430 amino acids: PaperBLAST, CDD, BRENDA::P00505
41% identical to

P17174 cytoplasmic aspartate aminotransferase (EC 2.6.1.1; EC 2.6.1.3) from Homo sapiens
AATC_HUMAN / P17174 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Homo sapiens (Human)
P17174 aspartate transaminase (EC 2.6.1.1) from Homo sapiens
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD, BRENDA::P17174
41% identical to

AAT3_ARATH / P46644 Aspartate aminotransferase 3, chloroplastic; Protein YELLOW-LEAF-SPECIFIC GENE 4; Transaminase A; EC 2.6.1.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_1_2
449 amino acids: PaperBLAST, CDD, SwissProt::P46644
40% identical to

AATM_CHICK / P00508 Aspartate aminotransferase, mitochondrial; mAspAT; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Transaminase A; EC 2.6.1.1; EC 2.6.1.7 from Gallus gallus (Chicken)
PFams: Aminotran_1_2
423 amino acids: PaperBLAST, CDD, SwissProt::P00508
40% identical to

P00503 aspartate aminotransferase subunit (EC 2.6.1.1) from Sus scrofa
AATC_PIG / P00503 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Sus scrofa (Pig)
PFams: Aminotran_1_2
413 amino acids: PaperBLAST, CDD, SwissProt::P00503
40% identical to

Ac3H11_1015 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_MocR
396 amino acids: PaperBLAST, CDD, reanno::acidovorax_3H11:Ac3H11_1015
40% identical to

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Aminotran_MocR
401 amino acids: PaperBLAST, CDD

AATC_CHICK / P00504 Aspartate aminotransferase, cytoplasmic; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A; EC 2.6.1.1; EC 2.6.1.3 from Gallus gallus (Chicken)
PFams: Aminotran_1_2
412 amino acids: PaperBLAST, CDD, SwissProt::P00504
40% identical to

HMM-only sequences

(Since these sequences' annotations are outside the definition for ilvE, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

ATNH_EMENI / Q5AV02 Branched-chain-amino-acid aminotransferase atnH; Aspercryptin biosynthesis cluster protein H; EC 2.6.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
396 amino acids: PaperBLAST, CDD