GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for liuE (hydroxymethylglutaryl-CoA lyase) in L-leucine catabolism

Or see other characterized proteins similar to liuE

Or see all steps for L-leucine catabolism

Or cluster curated proteins matching a keyword

Definition of liuE

Fetched 12 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 10 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 286-370 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) from Homo sapiens
HMGCL_HUMAN / P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Homo sapiens (Human)
P35914 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Homo sapiens
PFams: HMGL-like
325 amino acids: PaperBLAST, CDD, Compare to cluster

HMGCL_RAT / P97519 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Rattus norvegicus (Rat)
P97519 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Rattus norvegicus
PFams: HMGL-like
325 amino acids: PaperBLAST, CDD, Compare to cluster

Q9I2A0 hydroxymethylglutaryl-CoA lyase subunit (EC 4.1.3.26; EC 4.1.3.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
LIUE_PSEAE / Q9I2A0 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase; HIHG-CoA lyase; HMG-CoA lyase; (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase; EC 4.1.3.26; EC 4.1.3.4 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q9I2A0 3-Hydroxy-3-isohexenylglutaryl-CoA lyase (EC 4.1.3.26) from Pseudomonas aeruginosa PAO1
PFams: HMGL-like
300 amino acids: PaperBLAST, CDD, Compare to cluster

P13703 hydroxymethylglutaryl-CoA lyase monomer (EC 4.1.3.4) from Pseudomonas mevalonii
GB|AAA25895.1 hydroxymethylglutaryl-CoA lyase; EC 4.1.3.4 from Pseudomonas mevalonii
PFams: HMGL-like
301 amino acids: PaperBLAST, CDD, Compare to cluster

HMGC2_RAT / D4A5C3 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; EC 4.1.3.4 from Rattus norvegicus (Rat)
PFams: HMGL-like
343 amino acids: PaperBLAST, CDD, Compare to cluster

HMGCL_BACSU / O34873 Hydroxymethylglutaryl-CoA lyase YngG; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Bacillus subtilis (strain 168)
PFams: HMGL-like
299 amino acids: PaperBLAST, CDD, Compare to cluster

HMGCL_MOUSE / P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Mus musculus (Mouse)
PFams: HMGL-like
325 amino acids: PaperBLAST, CDD, Compare to cluster

HMGC2_HUMAN / Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase; er-cHL; EC 4.1.3.4 from Homo sapiens (Human)
PFams: HMGL-like
370 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS13115 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Pedobacter sp. GW460-11-11-14-LB5
PFams: HMGL-like
286 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b21125 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) from Sinorhizobium meliloti 1021
PFams: HMGL-like
289 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

CH_122457 3-hydroxy-3-methylglutaryl-coenzyme A lyase/3-methylglutaconyl-coenzyme A hydratase; EC 4.1.3.4; EC 4.2.1.18 from Emericella nidulans
PFams: HMGL-like, ECH_1, ECH_2
599 amino acids: PaperBLAST, CDD

HMGCL_ARATH / O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; EC 4.1.3.4 from Arabidopsis thaliana (Mouse-ear cress)
PFams: HMGL-like
468 amino acids: PaperBLAST, CDD