Other Characterized Proteins Similar to amaB

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to amaB

Finding the characterized proteins for amaB (L-2-aminoadipate semialdehyde dehydrogenase (AmaB/Pcd)) in L-lysine catabolism

Or see clustering for step amaB

Or see all steps for L-lysine catabolism

Or cluster curated proteins matching a keyword

Definition of amaB

Curated proteins or TIGRFams with EC 1.2.1.31
Ignore hits to Q4L235 when looking for 'other' hits (Beta-alanine-activating enzyme; Acyl-CoA synthetase family member 4; Protein NRPS998; EC 6.2.1.-. L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31))
Do not include HMM TIGR03443 (when considering EC numbers)
Ignore hits to P83402 when looking for 'other' hits (Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31)
Ignore hits to P84463 when looking for 'other' hits (Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31)
Curated sequence MONOMER-12387: Δ¹-piperideine-6-carboxylate dehydrogenase
UniProt sequence Q88CC3: SubName: Full=L-piperidine-6-carboxylate dehydrogenase {ECO:0000313|EMBL:AAN70823.1}; EC=1.2.1.21 {ECO:0000313|EMBL:AAN70823.1};
UniProt sequence Q92L07: SubName: Full=Putative aldehyde dehydrogenase transmembrane protein {ECO:0000313|EMBL:CAC47869.1}; EC=1.2.1.3 {ECO:0000313|EMBL:CAC47869.1};
Comment: Q4L235 is misannotated in BRENDA. TIGR03443 hits both amaB and the ATP-hydrolyzing L-2-aminoadipate reductase. P83402 and P84463 are short sequence fragments. In MetaCyc, MONOMER-20455 is annotated as performing this reaction but was not given this EC number. PP_5258 (Q88CC3) is in a newer version of metacyc. SMc04385 (Q92L07) was identified using fitness data.

Fetched 9 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 8 other characterized sequences. (Found 15 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for amaB.)

CH_123559 alpha-aminoadipate reductase from Candida albicans
PFams: AMP-binding, PP-binding, Epimerase, 3Beta_HSD, NAD_binding_4
1404 amino acids: PaperBLAST, CDD, CharProtDB::CH_123559
59% identical to

P07702 L-2-aminoadipate reductase (EC 1.2.1.95) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
LYS2_YEAST / P07702 L-2-aminoadipate reductase; Alpha-aminoadipate reductase; Alpha-AR; L-aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31; EC 1.2.1.95 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P07702 L-2-aminoadipate reductase (EC 1.2.1.95) from Saccharomyces cerevisiae
PFams: AMP-binding, PP-binding, Epimerase, NAD_binding_4
1392 amino acids: PaperBLAST, CDD

Q69P84 aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Oryza sativa
Q9FPK6 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Oryza sativa
PFams: Aldedh
509 amino acids: PaperBLAST, CDD, BRENDA::Q69P84
60% identical to

AL7A1_RAT / Q64057 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Rattus norvegicus (Rat)
PFams: Aldedh
539 amino acids: PaperBLAST, CDD

Q12572 L-2-aminoadipate reductase (EC 1.2.1.95) from Candida albicans
PFams: AMP-binding, PP-binding, Epimerase, 3Beta_HSD, NAD_binding_4
1391 amino acids: PaperBLAST, CDD, BRENDA::Q12572
56% identical to

AL7B4_ARATH / Q9SYG7 Aldehyde dehydrogenase family 7 member B4; Antiquitin-1; Turgor-responsive ALDH; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aldedh
508 amino acids: PaperBLAST, CDD, SwissProt::Q9SYG7
60% identical to

P49419 Alpha-aminoadipic semialdehyde dehydrogenase (EC 1.2.1.8; EC 1.2.1.31) from Homo sapiens
AL7A1_HUMAN / P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human)
P49419 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) from Homo sapiens
PFams: Aldedh
539 amino acids: PaperBLAST, CDD

AL7A1_MALDO / Q9ZPB7 Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Matured fruit 60 kDa protein; MF-60; EC 1.2.1.3 from Malus domestica (Apple) (Pyrus malus)
PFams: Aldedh
508 amino acids: PaperBLAST, CDD, SwissProt::Q9ZPB7
60% identical to

AL7A1_BRANA / Q41247 Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Brassica turgor-responsive/drought-induced gene 26 protein; Btg-26; EC 1.2.1.3 from Brassica napus (Rape)
PFams: Aldedh
494 amino acids: PaperBLAST, CDD, SwissProt::Q41247
59% identical to

M2PFR6 L-2-aminoadipate reductase (EC 1.2.1.95) from Gelatoporia subvermispora
A0A0S2LUS1 L-2-aminoadipate reductase (EC 1.2.1.95) from Gelatoporia subvermispora
PFams: Condensation, AMP-binding, PP-binding, Epimerase, 3Beta_HSD, NAD_binding_4
1417 amino acids: PaperBLAST, CDD, BRENDA::M2PFR6
51% identical to

LYS2_SCHPO / P40976 L-2-aminoadipate reductase; Alpha-aminoadipate reductase; Alpha-AR; L-aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31; EC 1.2.1.95 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
P40976 L-2-aminoadipate reductase (EC 1.2.1.95) from Schizosaccharomyces pombe
RF|NP_594314.1 aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31 from Schizosaccharomyces pombe
PFams: Condensation, AMP-binding, AMP-binding_C, PP-binding, Epimerase, NAD_binding_4
1419 amino acids: PaperBLAST, CDD

Q1W284 L-2-aminoadipate reductase (EC 1.2.1.95) from Saccharomycopsis fibuligera
PFams: AMP-binding, PP-binding, Epimerase, 3Beta_HSD, NAD_binding_4
1387 amino acids: PaperBLAST, CDD, BRENDA::Q1W284
51% identical to