Clusters of Characterized Proteins

Clustering the characterized proteins for hisM (L-lysine ABC transporter, permease component 1 (HisM)) in L-lysine catabolism

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Definition of hisM

• Curated sequence P0A2I7: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium
• Curated sequence P0AEU3: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1)
• Curated sequence Q9HU29: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Curated sequence AO356_05505: ABC transporter for L-Lysine, permease component 2
• Curated sequence AO356_09910: ABC transporter for L-Lysine, permease component 2
• Curated sequence Pf6N2E2_2960: ABC transporter for L-Lysine, permease component 2
• UniProt sequence Q88GX2: SubName: Full=Amino acid ABC transporter, membrane protein {ECO:0000313|EMBL:AAN69195.1};

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Escherichia coli

b2307 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
HISM_ECOLI / P0AEU3 Histidine transport system permease protein HisM from Escherichia coli (strain K12)
TC 3.A.1.3.29 / P0AEU3 Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
PFams: BPD_transp_1
Heteromeric, 238 amino acids: PaperBLAST, CDD (Cluster 1)

Organism unknown

Q88GX2 Amino acid ABC transporter, membrane protein
236 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas aeruginosa

TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: BPD_transp_1
Heteromeric, 230 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas fluorescens

AO356_05505 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
PFams: BPD_transp_1
Heteromeric, 236 amino acids: PaperBLAST, CDD (Cluster 1)

AO356_09910 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2C3
PFams: BPD_transp_1
Heteromeric, 229 amino acids: PaperBLAST, CDD (Cluster 1)

Pf6N2E2_2960 ABC transporter for L-Lysine, permease component 2 from Pseudomonas fluorescens FW300-N2E2
PFams: BPD_transp_1
Heteromeric, 236 amino acids: PaperBLAST, CDD (Cluster 1)

Salmonella typhimurium

HISM_SALTY / P0A2I7 Histidine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium
PFams: BPD_transp_1
Heteromeric, 235 amino acids: PaperBLAST, CDD (Cluster 1)