# pathway lysine step hisM # Cluster 1 229-238 amino acids (6/7 heteromeric) # TCDB::Q9HU29 3.A.1.3.23 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) heteromeric # SwissProt::P0A2I7,TCDB::P0A2I7 HISM_SALTY;; 3.A.1.3.1 Histidine transport system permease protein HisM;; Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720);; Salmonella typhimurium heteromeric # SwissProt::P0AEU3,TCDB::P0AEU3,ecocyc::HISM-MONOMER HISM_ECOLI;; 3.A.1.3.29;; b2307 Histidine transport system permease protein HisM;; Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential;; lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1) Escherichia coli (strain K12);; Escherichia coli (strain K12);; Escherichia coli K-12 substr. MG1655 heteromeric # UniProt::Q88GX2 Amino acid ABC transporter, membrane protein # reanno::pseudo5_N2C3_1:AO356_05505 AO356_05505 ABC transporter for L-Lysine, permease component 2 Pseudomonas fluorescens FW300-N2C3 heteromeric # reanno::pseudo5_N2C3_1:AO356_09910 AO356_09910 ABC transporter for L-Lysine, permease component 2 Pseudomonas fluorescens FW300-N2C3 heteromeric # reanno::pseudo6_N2E2:Pf6N2E2_2960 Pf6N2E2_2960 ABC transporter for L-Lysine, permease component 2 Pseudomonas fluorescens FW300-N2E2 heteromeric Cluster1 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR curated:TCDB::Q9HU29 curated:SwissProt::P0A2I7 curated:SwissProt::P0AEU3 curated:UniProt::Q88GX2 curated:reanno::pseudo5_N2C3_1:AO356_05505 curated:reanno::pseudo5_N2C3_1:AO356_09910 curated:reanno::pseudo6_N2E2:Pf6N2E2_2960