Other Characterized Proteins Similar to glk

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to glk

Finding the characterized proteins for glk (glucokinase) in D-maltose catabolism

Or see clustering for step glk

Or see all steps for D-maltose catabolism

Or cluster curated proteins matching a keyword

Definition of glk

Curated proteins or TIGRFams with EC 2.7.1.1
Curated proteins or TIGRFams with EC 2.7.1.2
UniProt sequence A8LLL9: SubName: Full=Glucokinase {ECO:0000313|EMBL:ABV93397.1}; EC=2.7.1.2 {ECO:0000313|EMBL:ABV93397.1};
UniProt sequence Q5GAN8: SubName: Full=General specificity hexokinase {ECO:0000313|EMBL:AAT74901.1};
Curated sequence MONOMER-19002: N-acetylglucosamine kinase (EC 2.7.1.59)
Ignore hits to CH_123431 when looking for 'other' hits (N-acetylglucosamine kinase)
Ignore hits to Q9ADE8 when looking for 'other' hits (polyphosphate-glucose phosphotransferase (EC 2.7.1.63))
UniProt sequence I7DXX1: SubName: Full=Glucokinase Glk {ECO:0000313|EMBL:AFO90274.1}; EC=2.7.1.2 {ECO:0000313|EMBL:AFO90274.1};
Comment: Dshi_1655 (A8LLL9) was identified using fitness data, is very important for growth on glucose and several glucose-containing disaccharides; and functional residues seem to be conserved. The related protein PGA1_c05420 (I7DXX1) also seems to be glk. Q5GAN8 = hexA from B. fragilis is a broad-specificity hexokinase (PMID:15659667). Q5GBH5 = rokA = MONOMER-19002 from B. fragilis is a glucose/mannose/NAG kinase (PMID:15659667). (MetaCyc lists it as NAG kinase only but it is just as active on glucose.) CH_123431 is nearly identical to a characterized broad-specificity hexose kinase, so ignore. SCO5059 (Q9ADE8) is reported to have ATP-glucokinase activity (PMID:24200789), so ignore.

Fetched 98 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 8 other characterized sequences. (Found 103 hits including self hits.)

Removing ignored items reduces this to 6 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for glk.)

b0394 fructokinase (EC 2.7.1.7; EC 2.7.1.4) from Escherichia coli K-12 substr. MG1655
P23917 fructokinase (EC 2.7.1.7; EC 2.7.1.4) from Escherichia coli (strain K12)
MAK_ECOLI / P23917 Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 from Escherichia coli (strain K12)
PFams: ROK, Glucokinase
302 amino acids: PaperBLAST, CDD, SwissProt::P23917
59% identical to

Sama_2231 glucokinase (EC 2.7.1.2) from Shewanella amazonensis SB2B
PFams: ROK, Glucokinase
299 amino acids: PaperBLAST, CDD

SMc03109 Mannokinase (EC 2.7.1.7) from Sinorhizobium meliloti 1021
PFams: ROK
298 amino acids: PaperBLAST, CDD, reanno::Smeli:SMc03109
52% identical to

Sama_2231 glucokinase (EC 2.7.1.2) from Shewanella amazonensis SB2B
PFams: ROK, Glucokinase
299 amino acids: PaperBLAST, CDD

Q76LT2 polyphosphate-dependent glucokinase subunit (EC 2.7.1.63) from Microlunatus phosphovorus
PFams: ROK
266 amino acids: PaperBLAST, CDD, metacyc::MONOMER-6061
50% identical to

P9WIN1 polyphosphate-dependent glucokinase (EC 2.7.1.63) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PPGK_MYCTA / A5U654 Polyphosphate glucokinase; Poly(P) glucokinase; ATP-dependent glucokinase; Polyphosphate--glucose phosphotransferase; EC 2.7.1.63; EC 2.7.1.2 from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
PPGK_MYCTU / P9WIN1 Polyphosphate glucokinase; Poly(P) glucokinase; ATP-dependent glucokinase; Polyphosphate--glucose phosphotransferase; EC 2.7.1.63; EC 2.7.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: ROK
265 amino acids: PaperBLAST, CDD

b1119 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli K-12 substr. MG1655
P75959 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli (strain K12)
NAGK_ECOLI / P75959 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Escherichia coli (strain K12)
GB|ABB62126.1 N-acetyl-D-glucosamine kinase; EC 2.7.1.59 from Escherichia coli K12
PFams: ROK, Glucokinase
303 amino acids: PaperBLAST, CDD, CharProtDB::CH_002679
42% identical to

Sama_2231 glucokinase (EC 2.7.1.2) from Shewanella amazonensis SB2B
PFams: ROK, Glucokinase
299 amino acids: PaperBLAST, CDD

Q8R8N4 ADP-specific glucokinase (EC 2.7.1.147) from Caldanaerobacter subterraneus subsp. tengcongensis
PFams: ROK
312 amino acids: PaperBLAST, CDD, BRENDA::Q8R8N4
41% identical to

Q8RDE9 glucokinase (EC 2.7.1.2) from Caldanaerobacter subterraneus subsp. tengcongensis
PFams: ROK
315 amino acids: PaperBLAST, CDD

NAGK_SALTY / Q8ZPZ9 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: ROK, Glucokinase
303 amino acids: PaperBLAST, CDD, SwissProt::Q8ZPZ9
40% identical to

Sama_2231 glucokinase (EC 2.7.1.2) from Shewanella amazonensis SB2B
PFams: ROK, Glucokinase
299 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for glk.)

CH_123431 N-acetylglucosamine kinase from Candida albicans
PFams: Hexokinase_1, Hexokinase_2
493 amino acids: PaperBLAST, CDD, CharProtDB::CH_123431
99% identical to

HXK1_CANAL / Q59RW5 N-acetylglucosamine kinase 1; GlcNAc kinase 1; Hexokinase 1; EC 2.7.1.59; EC 2.7.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: Hexokinase_1, Hexokinase_2
493 amino acids: PaperBLAST, CDD

Q9ADE8 polyphosphate-glucose phosphotransferase (EC 2.7.1.63) from Streptomyces coelicolor
PFams: ROK
246 amino acids: PaperBLAST, CDD, BRENDA::Q9ADE8
57% identical to