Other Characterized Proteins Similar to manX

Finding the characterized proteins for manX (mannose PTS system, EII-AB component ManX/ManL) in D-mannose catabolism

Or see clustering for step manX

Or see all steps for D-mannose catabolism

Or cluster curated proteins matching a keyword

Definition of manX

• Curated sequence CH_088329: PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191. PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIAB component
• Curated sequence D2BKY7: Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine
• Curated sequence E1UCI0: PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN
• Ignore hits to Q5M5W6 when looking for 'other' hits (ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN)
• Ignore hits to Q9S4L5 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
• Ignore hits to Q04GK1 when looking for 'other' hits (Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system)
• Ignore hits to Q2QKM4 when looking for 'other' hits (ManL aka EIIAB, component of Glucose porter, ManLMN)
• Comment: E. coli has manXYZ, where manX has EII-AB, manY has EII-C, and manZ has EII-D. (ManZ is listed twice with slightly different sequence lengths). Similar systems are known in Lactococcus lactis, Listeria monocytogenes, and Streptococcus thermophilus. However, the S. thermophilus system seems not to be active due to a defective IIC domain (PMID:12957931), so those proteins are marked ignore. L. monocytogenes also has a PTS-like regulatory system, mpoABCD, which is not included. (It is reported to act as a glucose transporter, but slowly; not clear if it transports mannose.) There's also a paper about manLMN from Streptococcus salivarius, but I don't think it is actually characterized, so ignore. Closely related to some systems with unclear specificity, ignore those.

Fetched 3 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 4 other characterized sequences. (Found 7 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for manX.)

Q9S4L5 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Streptococcus salivarius
PFams: EIIA-man, PTSIIB_sorb
330 amino acids: PaperBLAST, CDD, BRENDA::Q9S4L5
78% identical to

TC 4.A.6.1.11 / D2BKY7 Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 329 amino acids: PaperBLAST, CDD

TC 4.A.6.1.7 / Q5M5W6 ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 330 amino acids: PaperBLAST, CDD, TCDB::Q5M5W6
76% identical to

TC 4.A.6.1.11 / D2BKY7 Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 329 amino acids: PaperBLAST, CDD

TC 4.A.6.1.6 / Q2QKM4 ManL aka EIIAB, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 324 amino acids: PaperBLAST, CDD, TCDB::Q2QKM4
63% identical to

TC 4.A.6.1.15 / E1UCI0 PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 321 amino acids: PaperBLAST, CDD

TC 4.A.6.1.10 / Q04GK1 Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 331 amino acids: PaperBLAST, CDD, TCDB::Q04GK1
62% identical to

TC 4.A.6.1.15 / E1UCI0 PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 321 amino acids: PaperBLAST, CDD