Other Characterized Proteins Similar to HMIT

Finding the characterized proteins for HMIT (myo-inositol:H+ symporter) in myo-inositol catabolism

Or see clustering for step HMIT

Or see all steps for myo-inositol catabolism

Or cluster curated proteins matching a keyword

Definition of HMIT

• Curated sequence CH_091598: inositol transporter 4. Inositol transporter 4; Myo-inositol-proton symporter INT4; Protein INOSITOL TRANSPORTER 4. High affinity (0.24mM) plasma membrane myoinositol-specific H+ symporter, INT4
• Curated sequence Q921A2: Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13
• Curated sequence Q96QE2: Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13. Myoinositol:H+ symporter, HMIT (also transport other inositols including scyllo-, muco- and chiro-, but not allo-inositol) (Aouameur et al., 2007). Expressed in the Golgi of the hippocampus and cortex. May also transport inositoltriphosphate (Di Daniel et al., 2009). Interacts directly with γ-secretase (9.B.47.1.1) to regulate its activity and the production of Abeta production, important in Alzheimer's disease
• Curated sequence Q9C757: Probable inositol transporter 2. Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H+ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll
• Curated sequence Q9ZQP6: Probable inositol transporter 3

Fetched 5 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 6 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for HMIT.)

INT1_ARATH / Q8VZR6 Inositol transporter 1 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.66 / Q8VZR6 The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62) from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, SwissProt::Q8VZR6
43% identical to

INT3_ARATH / Q9ZQP6 Probable inositol transporter 3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1, TRI12, Sugar_tr
580 amino acids: PaperBLAST, CDD