Clusters of Characterized Proteins

Clustering the characterized proteins for HMIT (myo-inositol:H+ symporter) in myo-inositol catabolism

Or see other characterized proteins similar to HMIT

Or see all steps for myo-inositol catabolism

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Definition of HMIT

• Curated sequence CH_091598: inositol transporter 4. Inositol transporter 4; Myo-inositol-proton symporter INT4; Protein INOSITOL TRANSPORTER 4. High affinity (0.24mM) plasma membrane myoinositol-specific H+ symporter, INT4
• Curated sequence Q921A2: Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13
• Curated sequence Q96QE2: Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13. Myoinositol:H+ symporter, HMIT (also transport other inositols including scyllo-, muco- and chiro-, but not allo-inositol) (Aouameur et al., 2007). Expressed in the Golgi of the hippocampus and cortex. May also transport inositoltriphosphate (Di Daniel et al., 2009). Interacts directly with γ-secretase (9.B.47.1.1) to regulate its activity and the production of Abeta production, important in Alzheimer's disease
• Curated sequence Q9C757: Probable inositol transporter 2. Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H+ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll
• Curated sequence Q9ZQP6: Probable inositol transporter 3

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Arabidopsis thaliana

INT4_ARATH / O23492 Inositol transporter 4; Myo-inositol-proton symporter INT4; Protein INOSITOL TRANSPORTER 4 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.62 / O23492 High affinity (0.24mM) plasma membrane myoinositol-specific H+ symporter, INT4 from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_193381.1 inositol transporter 4 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1, TRI12, Sugar_tr
582 amino acids: PaperBLAST, CDD (Cluster 1)

INT2_ARATH / Q9C757 Probable inositol transporter 2 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.63 / Q9C757 Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H+ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1, TRI12, Sugar_tr
580 amino acids: PaperBLAST, CDD (Cluster 1)

INT3_ARATH / Q9ZQP6 Probable inositol transporter 3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1, TRI12, Sugar_tr
580 amino acids: PaperBLAST, CDD (Cluster 1)

Homo sapiens

MYCT_HUMAN / Q96QE2 Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13 from Homo sapiens (Human)
TC 2.A.1.1.25 / Q96QE2 Myoinositol:H+ symporter, HMIT (also transport other inositols including scyllo-, muco- and chiro-, but not allo-inositol) (Aouameur et al., 2007). Expressed in the Golgi of the hippocampus and cortex. May also transport inositoltriphosphate (Di Daniel et al., 2009). Interacts directly with γ-secretase (9.B.47.1.1) to regulate its activity and the production of Abeta production, important in Alzheimer's disease from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1, Sugar_tr
648 amino acids: PaperBLAST, CDD (Cluster 1)

Rattus norvegicus

MYCT_RAT / Q921A2 Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1, Sugar_tr
637 amino acids: PaperBLAST, CDD (Cluster 1)