GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for iolT (myo-inositol:H+ symporter) in myo-inositol catabolism

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Definition of iolT

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 17 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 473-609 amino acids (not heteromeric)

INT1_ARATH / Q8VZR6 Inositol transporter 1 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.66 / Q8VZR6 The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62) from Arabidopsis thaliana (Mouse-ear cress)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, Compare to cluster

PLT5_ARATH / Q8VZ80 Polyol transporter 5; Protein POLYOL TRANSPORTER 5; AtPLT5; Sugar-proton symporter PLT5 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.34 / Q8VZ80 The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H+ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_188513.1 polyol transporter 5 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
539 amino acids: PaperBLAST, CDD, Compare to cluster

ITR1_YEAST / P30605 Myo-inositol transporter 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.1.1.8 / P30605 Myoinositol:H+ symporter from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_010785.1 Myo-inositol transporter 1 from Saccharomyces cerevisiae
PFams: Sugar_tr, MFS_1, MFS_3
584 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123508 myo-inositol transporter 2 from Candida albicans
PFams: Sugar_tr, MFS_1
554 amino acids: PaperBLAST, CDD, Compare to cluster

IOLT_BACSU / O34718 Major myo-inositol transporter IolT from Bacillus subtilis (strain 168)
TC 2.A.1.1.26 / O34718 Major myoinositol:H+ symporter, IolT from Bacillus subtilis
PFams: Sugar_tr, MFS_1
473 amino acids: PaperBLAST, CDD, Compare to cluster

ITR2_YEAST / P30606 Myo-inositol transporter 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.1.1.104 / P30606 Myo-inositol transporter 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Sugar_tr, TRI12, MFS_1
609 amino acids: PaperBLAST, CDD, Compare to cluster

ITR2_SCHPO / P87110 Myo-inositol transporter 2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
RF|NP_593320.1 MFS myo-inositol transporter from Schizosaccharomyces pombe
PFams: Sugar_tr, MFS_1
557 amino acids: PaperBLAST, CDD, Compare to cluster

ITR1_SCHPO / Q10286 Myo-inositol transporter 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
GI|1420856 myo-inositol transporter Itr1 from Schizosaccharomyces pombe
PFams: Sugar_tr, MFS_1, TRI12
575 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.126 / A8DCT2 Myo inositol uptake porter of 574 aas and 12 TMSs, Fst1 from Gibberella moniliformis
PFams: Sugar_tr, MFS_1, TRI12
574 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.131 / AIU34725.1 Myo-inositol-specific uptake transporter, ITR1 of 509 aas and 12 TMSs from Pneumocystis carinii
PFams: Sugar_tr, MFS_1, MFS_1
507 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.20 / Q01440 Myoinositol:H+ symporter, MIT from Leishmania donovani
PFams: Sugar_tr, MFS_1
547 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.53 / Q8NTX0 Myo-Inositol uptake porter, IolT1 (Km=0.2mM) from Corynebacterium glutamicum (Brevibacterium flavum)
PFams: Sugar_tr, MFS_1, MFS_1
491 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 456-508 amino acids (not heteromeric)

TC 2.A.1.1.120 / E1WAV3 Major myo-inositol transporter, IolT1, of 456 aas from Salmonella typhimurium (strain SL1344)
PFams: Sugar_tr, MFS_1
456 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.121 / E1WAV4 Minor myo-inositol transporter, IolT2, of 478 aas from Salmonella typhimurium (strain SL1344)
PFams: Sugar_tr, MFS_1
478 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.54 / Q8NL90 Myo-Inositol (Km=0.45mM) uptake porter, IolT2 (Krings et al., 2006).  Can not transport D-glucose from Corynebacterium glutamicum (Brevibacterium flavum)
PFams: Sugar_tr, MFS_1
508 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 630-638 amino acids (not heteromeric)

CH_123411 potential myo-inositol transporter from Candida albicans
PFams: Sugar_tr, MFS_1
630 amino acids: PaperBLAST, CDD, Compare to cluster

CH_124311 major myo-inositol transporter iolT from Magnaporthe grisea 70-15
PFams: Sugar_tr, MFS_1
638 amino acids: PaperBLAST, CDD, Compare to cluster