GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for PCBD (pterin-4-alpha-carbinoalamine dehydratase) in L-phenylalanine catabolism

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Definition of PCBD

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 2 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 96-136 amino acids (not heteromeric)

PHS_CHICK / O73930 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; cDcoH; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Gallus gallus (Chicken)
PFams: Pterin_4a
104 amino acids: PaperBLAST, CDD, Compare to cluster

Q48G05 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Pseudomonas syringae
PFams: Pterin_4a
118 amino acids: PaperBLAST, CDD, Compare to cluster

PHS2_HUMAN / Q9H0N5 Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; EC 4.2.1.96 from Homo sapiens (Human)
Q9H0N5 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Homo sapiens
Q9H0N5 Pterin-4-alpha-carbinolamine dehydratase 2 (EC 4.2.1.96) from Homo sapiens
PFams: Pterin_4a
130 amino acids: PaperBLAST, CDD, Compare to cluster

PHS_SCHPO / O42658 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Overlapping meiotic transcript 2; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
RF|NP_594610.1 4-alpha-hydroxytetrahydrobiopterin dehydratase (predicted); EC 4.2.1.96 from Schizosaccharomyces pombe
PFams: Pterin_4a
96 amino acids: PaperBLAST, CDD, Compare to cluster

PHS_HUMAN / P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human)
PHS_RAT / P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat)
P61457 Pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96) from Homo sapiens
PFams: Pterin_4a
104 amino acids: PaperBLAST, CDD, Compare to cluster

PHS2_MOUSE / Q9CZL5 Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; EC 4.2.1.96 from Mus musculus (Mouse)
PFams: Pterin_4a
136 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 218-220 amino acids (not heteromeric)

B6TSX9 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Zea mays
PFams: Pterin_4a
218 amino acids: PaperBLAST, CDD, Compare to cluster

ATP1_ARATH / Q9LU63 Probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic; 4-alpha-hydroxy-tetrahydropterin dehydratase; PCD/DCoH-like protein 1; Protein AIRP2 TARGET PROTEIN 1; Protein SDIR1-INTERACTING PROTEIN 1; EC 4.2.1.96 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Pterin_4a
220 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/5 heteromeric)

Q2Q449 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) from Toxoplasma gondii
PFams: Pterin_4a
104 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q48G05 from Cluster 1, but similarity to seed sequence is below thresholds)

PHS_DROME / O76454 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Drosophila melanogaster (Fruit fly)
PFams: Pterin_4a
192 amino acids: PaperBLAST, CDD

PHS_YEAST / P38744 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Pterin_4a
120 amino acids: PaperBLAST, CDD

PDL2_ARATH / Q6QJ72 Pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial; 4-alpha-hydroxy-tetrahydropterin dehydratase; PCD/DCoH-like protein 2; EC 4.2.1.96 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Pterin_4a
187 amino acids: PaperBLAST, CDD

A8IT23 pterin-4alpha-carbinolamine dehydratase (EC 4.2.1.96) from Chlamydomonas reinhardtii
PFams: Pterin_4a
191 amino acids: PaperBLAST, CDD