GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for put1 (proline dehydrogenase) in L-proline catabolism

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Definition of put1

Fetched 39 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 38 of these sequences

Found 6 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 1053-1333 amino acids (not heteromeric)

B1014 fused DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase PutA (EC 1.5.5.2; EC 1.2.1.88) from Escherichia coli K-12 substr. MG1655
P09546 fused DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase PutA (EC 1.5.5.2; EC 1.2.1.88) from Escherichia coli (strain K12)
PUTA_ECOLI / P09546 Bifunctional protein PutA; EC 1.5.5.2; EC 1.2.1.88 from Escherichia coli (strain K12)
P09546 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); proline dehydrogenase (EC 1.5.5.2) from Escherichia coli
GB|BAA35791.1 proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; EC 1.5.1.12; EC 1.5.99.8 from Escherichia coli K12
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1320 amino acids: PaperBLAST, CDD, Compare to cluster

Shewana3_0819 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Shewanella sp. ANA-3
PFams: Pro_dh-DNA_bdg, Pro_dh, Aldedh
1064 amino acids: PaperBLAST, CDD, Compare to cluster

RR42_RS20125 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Cupriavidus basilensis 4G11
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1333 amino acids: PaperBLAST, CDD, Compare to cluster

HSERO_RS00905 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Herbaspirillum seropedicae SmR1
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1230 amino acids: PaperBLAST, CDD, Compare to cluster

BWI76_RS10795 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Klebsiella michiganensis M5al
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1320 amino acids: PaperBLAST, CDD, Compare to cluster

HP15_2688 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Marinobacter adhaerens HP15
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1209 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_c11750 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Phaeobacter inhibens BS107
PFams: Pro_dh-DNA_bdg, Pro_dh, Aldedh
1158 amino acids: PaperBLAST, CDD, Compare to cluster

Sama_2676 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Shewanella amazonensis SB2B
PFams: Pro_dh-DNA_bdg, Pro_dh, Aldedh
1058 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_2850 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Acidovorax sp. GW101-3H11
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1261 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS23695 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Azospirillum brasilense Sp245
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1235 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_3079 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Pseudomonas stutzeri RCH2
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1053 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_12810 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) from Pseudomonas fluorescens FW300-N2E3
PFams: PRODH, Pro_dh-DNA_bdg, Pro_dh, Aldedh
1317 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 377-386 amino acids (1/7 heteromeric)

O59089 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus horikoshii
PFams: DAO, FAD_binding_2, Pyr_redox, NAD_binding_8
Heteromeric, 382 amino acids: PaperBLAST, CDD, Compare to cluster

O59445 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus horikoshii
PFams: DAO, FAD_binding_2, NAD_binding_8
377 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JFG2 proline dehydrogenase (EC 1.5.5.2) from Thermococcus kodakarensis
PFams: DAO, FAD_binding_2
385 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JFG7 proline dehydrogenase (EC 1.5.5.2) from Thermococcus kodakarensis
PFams: DAO, Pyr_redox, FAD_binding_2, NAD_binding_8
386 amino acids: PaperBLAST, CDD, Compare to cluster

Q76M73 proline dehydrogenase (EC 1.5.5.2) from Thermococcus profundus
PFams: DAO, FAD_binding_2, NAD_binding_8
385 amino acids: PaperBLAST, CDD, Compare to cluster

Q8U022 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus furiosus
PFams: DAO, FAD_binding_2, NAD_binding_8
378 amino acids: PaperBLAST, CDD, Compare to cluster

Q8U1G2 proline dehydrogenase (EC 1.5.5.2) from Pyrococcus furiosus
PFams: DAO, FAD_binding_2, Pyr_redox, NAD_binding_8
382 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 398-536 amino acids (not heteromeric)

V9XZ65 proline dehydrogenase (EC 1.5.5.2) from Jatropha curcas
PFams: Pro_dh
494 amino acids: PaperBLAST, CDD, Compare to cluster

P92983 proline dehydrogenase 1 (EC 1.5.5.2) from Arabidopsis thaliana
PROD1_ARATH / P92983 Proline dehydrogenase 1, mitochondrial; Osmotic stress-induced proline dehydrogenase; Proline oxidase; Protein EARLY RESPONSIVE TO DEHYDRATION 5; EC 1.5.5.2 from Arabidopsis thaliana (Mouse-ear cress)
P92983 proline dehydrogenase (EC 1.5.5.2) from Arabidopsis thaliana
PFams: Pro_dh
499 amino acids: PaperBLAST, CDD, Compare to cluster

Q6NKX1 proline dehydrogenase 2 (EC 1.5.5.2) from Arabidopsis thaliana
PROD2_ARATH / Q6NKX1 Proline dehydrogenase 2, mitochondrial; Osmotic stress-induced proline dehydrogenase; Proline oxidase; EC 1.5.5.2 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Pro_dh
476 amino acids: PaperBLAST, CDD, Compare to cluster

HYPDH_MOUSE / Q8VCZ9 Hydroxyproline dehydrogenase; HYPDH; Kidney and liver proline oxidase 1; MmPOX1; Probable proline dehydrogenase 2; Probable proline oxidase 2; Proline oxidase-like protein; PO; Proline oxidase; EC 1.5.5.3; EC 1.5.5.2 from Mus musculus (Mouse)
PFams: Pro_dh
456 amino acids: PaperBLAST, CDD, Compare to cluster

Q9UF12 hydroxyproline dehydrogenase (EC 1.5.5.3) from Homo sapiens
HYPDH_HUMAN / Q9UF12 Hydroxyproline dehydrogenase; HYPDH; Kidney and liver proline oxidase 1; HsPOX1; Probable proline dehydrogenase 2; Probable proline oxidase 2; EC 1.5.5.3; EC 1.5.5.2 from Homo sapiens (Human)
Q9UF12 hydroxyproline dehydrogenase (EC 1.5.5.3) from Homo sapiens
PFams: Pro_dh
536 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_0119 Proline dehydrogenase (EC 1.5.5.2) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: Pro_dh
398 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 566-681 amino acids (not heteromeric)

O43272 mitochondrial proline dehydrogenase 1 (EC 1.5.5.2) from Homo sapiens
PROD_HUMAN / O43272 Proline dehydrogenase 1, mitochondrial; Proline oxidase; Proline oxidase 2; p53-induced gene 6 protein; EC 1.5.5.2 from Homo sapiens (Human)
O43272 proline dehydrogenase (EC 1.5.5.2) from Homo sapiens
PFams: Pro_dh
600 amino acids: PaperBLAST, CDD, Compare to cluster

Q4CVA1 proline dehydrogenase (EC 1.5.5.2) from Trypanosoma cruzi
PFams: Pro_dh
566 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WU79 proline dehydrogenase (EC 1.5.5.2) from Mus musculus
PFams: Pro_dh
599 amino acids: PaperBLAST, CDD, Compare to cluster

PROD_CAEEL / O45228 Proline dehydrogenase 1, mitochondrial; Proline oxidase; EC 1.5.5.2 from Caenorhabditis elegans
PFams: Pro_dh
616 amino acids: PaperBLAST, CDD, Compare to cluster

PROD_DROME / Q04499 Proline dehydrogenase 1, mitochondrial; Proline oxidase; Protein sluggish-A; EC 1.5.5.2 from Drosophila melanogaster (Fruit fly)
PFams: Pro_dh
681 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 302-310 amino acids (not heteromeric)

PROD1_BACSU / O32179 Proline dehydrogenase 1; PRODH 1; Proline oxidase 1; EC 1.5.5.2 from Bacillus subtilis (strain 168)
PFams: Pro_dh
302 amino acids: PaperBLAST, CDD, Compare to cluster

PROD2_BACSU / P94390 Proline dehydrogenase 2; PRODH 2; Proline oxidase 2; EC 1.5.5.2 from Bacillus subtilis (strain 168)
PFams: Pro_dh
303 amino acids: PaperBLAST, CDD, Compare to cluster

PRODH_THET2 / Q72IB8 Proline dehydrogenase; PRODH; Proline oxidase; TtPRODH; EC 1.5.5.2 from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Q72IB8 proline dehydrogenase (EC 1.5.5.2) from Thermus thermophilus
PFams: Pro_dh
307 amino acids: PaperBLAST, CDD, Compare to cluster

PROD1_BACNA / Q8RMG1 Proline dehydrogenase 1; PRODH 1; Proline oxidase 1; EC 1.5.5.2 from Bacillus subtilis subsp. natto
PFams: Pro_dh
302 amino acids: PaperBLAST, CDD, Compare to cluster

PRODH_DEIRA / Q9RW55 Proline dehydrogenase; PRODH; DrPRODH; Proline oxidase; EC 1.5.5.2 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
PFams: Pro_dh
310 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 483-493 amino acids (1/2 heteromeric)

O59088 proline dehydrogenase (subunit 2/2) (EC 1.5.5.2) from Pyrococcus horikoshii
PFams: Fer2_4, Thi4, FAD_oxidored, Pyr_redox_2, Pyr_redox_2, SO_alpha_A3
Heteromeric, 493 amino acids: PaperBLAST, CDD, Compare to cluster

Q76M76 proline dehydrogenase (EC 1.5.5.2) from Thermococcus profundus
PFams: Fer2_4, AlaDh_PNT_C, FAD_binding_3, FAD_binding_2, FAD_oxidored, GIDA, HI0933_like, Pyr_redox_2, NAD_binding_8, Pyr_redox_3, Pyr_redox
483 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

PUT1_YEAST / P09368 Proline dehydrogenase, mitochondrial; Proline oxidase; EC 1.5.5.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Pro_dh
476 amino acids: PaperBLAST, CDD

CA265_RS11605 Proline dehydrogenase (EC 1.5.5.2) from Pedobacter sp. GW460-11-11-14-LB5
PFams: Pro_dh
394 amino acids: PaperBLAST, CDD
(similar to BRENDA::P92983 from Cluster 3, but similarity to seed sequence is below thresholds)