GapMind for catabolism of small carbon sources


Clusters of Characterized Proteins

Clustering the characterized proteins for SLC5A8 (sodium-coupled monocarboxylate transporter) in propionate catabolism

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Definition of SLC5A8

Fetched 1 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 0 of these sequences

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Homo sapiens

SC5A8_HUMAN / Q8N695 Sodium-coupled monocarboxylate transporter 1; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8 from Homo sapiens (Human)
TC 2.A.21.5.3 / Q8N695 Na+-dependent short chain fatty acid transporter SLC5A8 (tumor suppressor gene product, down-regulated in colon cancer) (substrates: lactate, pyruvate, acetate, propionate, butyrate (Km ≈1 mM)) [propionate:Na+ = 1:3] (Miyauchi et al., 2004). Pyroglutamate (5-oxoproline) is also transported in a Na+- coupled mechanism (Miyauchi et al., 2010). SMCT1 and SMCT2 may transport monocarboxylate drugs (e.g. nicotinate and its derivatives) across the intestinal brush boarder membrane
PFams: SSF
610 amino acids: PaperBLAST, CDD (Singleton 1)