Other Characterized Proteins Similar to prpB

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to prpB

Finding the characterized proteins for prpB (2-methylisocitrate lyase) in propionate catabolism

Or see clustering for step prpB

Or see all steps for propionate catabolism

Or cluster curated proteins matching a keyword

Definition of prpB

Curated proteins or TIGRFams with EC 4.1.3.30
Ignore hits to items matching 4.1.3.1 when looking for 'other' hits
Comment: Many 2-methylisocitrate lyases are closely related to isocitrate lyases (EC 4.1.3.1)

Fetched 26 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 21 other characterized sequences. (Found 47 hits including self hits.)

Removing ignored items reduces this to 4 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for prpB.)

CH_123497 Isocitrate lyase from Candida albicans
PFams: ICL, PEP_mutase
550 amino acids: PaperBLAST, CDD, CharProtDB::CH_123497
74% identical to

ACEA_YARLI / P41555 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
PFams: ICL, PEP_mutase
540 amino acids: PaperBLAST, CDD

P11435 carboxyphosphonoenolpyruvate phosphonomutase monomer (EC 2.7.8.23) from Streptomyces hygroscopicus
PFams: PEP_mutase, ICL
295 amino acids: PaperBLAST, CDD, metacyc::MONOMER-15044
42% identical to

PRPB2_CORGL / Q8NSL2 Probable 2-methylisocitrate lyase 2; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: PEP_mutase, ICL
307 amino acids: PaperBLAST, CDD

A0A0M3WPI5 carboxyphosphonoenolpyruvate phosphonomutase (EC 2.7.8.23) from Kitasatospora phosalacinea
PFams: PEP_mutase, ICL
295 amino acids: PaperBLAST, CDD, metacyc::MONOMER-19768
40% identical to

PRPB1_CORGL / Q8NSH8 Probable 2-methylisocitrate lyase 1; 2-MIC; MICL; (2R,3S)-2-methylisocitrate lyase; EC 4.1.3.30 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: PEP_mutase, ICL
305 amino acids: PaperBLAST, CDD

Q0QLE4 2,3-dimethylmalate lyase subunit (EC 4.1.3.32) from Eubacterium barkeri
DML_EUBBA / Q0QLE4 2,3-dimethylmalate lyase; EC 4.1.3.32 from Eubacterium barkeri (Clostridium barkeri)
PFams: PEP_mutase, ICL
289 amino acids: PaperBLAST, CDD, SwissProt::Q0QLE4
40% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for prpB.)

Q5YLB6 isocitrate lyase (EC 4.1.3.1) from Paracoccidioides brasiliensis
PFams: ICL, PEP_mutase
537 amino acids: PaperBLAST, CDD, BRENDA::Q5YLB6
85% identical to

ACEA_EMENI / P28298 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PDB|1DQU_A isocitrate lyase; EC 4.1.3.1 from Emericella nidulans
PFams: ICL, PEP_mutase
538 amino acids: PaperBLAST, CDD

Q4HYR2 isocitrate lyase (EC 4.1.3.1) from Fusarium graminearum
PFams: ICL, PEP_mutase
546 amino acids: PaperBLAST, CDD, BRENDA::Q4HYR2
84% identical to

ACEA_NEUCR / P28299 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
PFams: ICL, PEP_mutase
548 amino acids: PaperBLAST, CDD

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: ICL, PEP_mutase, ICL
432 amino acids: PaperBLAST, CDD, SwissProt::P42449
79% identical to

P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis
PFams: ICL, PEP_mutase, ICL
428 amino acids: PaperBLAST, CDD

Q9P8Q7 isocitrate lyase (EC 4.1.3.1) from Candida albicans
PFams: ICL, PEP_mutase
550 amino acids: PaperBLAST, CDD, BRENDA::Q9P8Q7
74% identical to

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus
PFams: ICL, ICL
436 amino acids: PaperBLAST, CDD, BRENDA::Q8RPZ0
71% identical to

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
PFams: ICL, PEP_mutase, ICL
450 amino acids: PaperBLAST, CDD, reanno::PV4:5208774
63% identical to

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
PFams: ICL, PEP_mutase, ICL
439 amino acids: PaperBLAST, CDD, reanno::SB2B:6938260
61% identical to

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
PFams: ICL, PEP_mutase, ICL
441 amino acids: PaperBLAST, CDD, reanno::pseudo1_N1B4:Pf1N1B4_4042
62% identical to

b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655
P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12)
PFams: ICL, PEP_mutase, ICL
434 amino acids: PaperBLAST, CDD, SwissProt::P0A9G6
61% identical to

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
PFams: ICL, PEP_mutase, ICL
440 amino acids: PaperBLAST, CDD, reanno::MR1:200655
62% identical to

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans
PFams: ICL, PEP_mutase, ICL, Malate_synthase
968 amino acids: PaperBLAST, CDD, SwissProt::Q10663
63% identical to

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
PFams: ICL, PEP_mutase, ICL
434 amino acids: PaperBLAST, CDD, reanno::Koxy:BWI76_RS01665
61% identical to

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus
PFams: ICL, PEP_mutase, ICL
437 amino acids: PaperBLAST, CDD, BRENDA::Q97YI8
58% identical to

Ac3H11_2831 Isocitrate lyase (EC 4.1.3.1) from Acidovorax sp. GW101-3H11
PFams: ICL, PEP_mutase, ICL
443 amino acids: PaperBLAST, CDD, reanno::acidovorax_3H11:Ac3H11_2831
57% identical to

ACEA_BRANA / P25248 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Brassica napus (Rape)
PFams: ICL, PEP_mutase
576 amino acids: PaperBLAST, CDD, SwissProt::P25248
56% identical to

P28297 isocitrate lyase (EC 4.1.3.1) from Arabidopsis thaliana
ACEA_ARATH / P28297 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: ICL, PEP_mutase
576 amino acids: PaperBLAST, CDD, SwissProt::P28297
56% identical to

ACEA_ORYSJ / Q6Z6M4 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Oryza sativa subsp. japonica (Rice)
PFams: ICL, PEP_mutase
572 amino acids: PaperBLAST, CDD, SwissProt::Q6Z6M4
54% identical to