Finding the characterized proteins for MCT4 (pyruvate symporter MCT4 (SLC16A3)) in pyruvate catabolism
Or see clustering for step MCT4
Or see all steps for pyruvate catabolism
Or cluster curated proteins matching a keyword
Definition of MCT4
Fetched 1 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 5 other characterized sequences. (Found 6 hits including self hits.)
(Sequences that are similar to these will not be high-confidence candidates for MCT4.)
MOT2_MESAU / P53988 Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7 from Mesocricetus auratus (Golden hamster)
PFams: MFS_1
484 amino acids: PaperBLAST, CDD, SwissProt::P53988
44% identical to
TC 2.A.1.13.6 / O15427 Plasma membrane proton-linked monocarboxylate transporter, MCT4 (SLC16A3). Catalyzes the rapid low affinity plasma membrane transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate from Homo sapiens
PFams: MFS_1
465 amino acids: PaperBLAST, CDD
TC 2.A.1.13.5 / O60669 Low affinity monocarboxylate transporter-2 (MCT2). Transports γ-hydroxybutyrate (Wang and Morris, 2007). MCT2 requires the ancillary protein, embigin (Q6PCB8; 8.A.23.1.2) for plasma membrane localization (Ovens et al., 2010). It is present in neurons but not astrocytes where the low affinity MCT1 and MCT4 predominate (Hertz and Dienel 2013). Partially localizes to the peroxysomal membrane (Visser et al. 2007). MCT1 is a negative regulator and MCT2 a positive regulator of osteoclast differentiation, while MCT2 is required for bone resorption by osteoclasts from Homo sapiens (Human)
PFams: MFS_1
478 amino acids: PaperBLAST, CDD, TCDB::O60669
46% identical to
TC 2.A.1.13.6 / O15427 Plasma membrane proton-linked monocarboxylate transporter, MCT4 (SLC16A3). Catalyzes the rapid low affinity plasma membrane transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate from Homo sapiens
PFams: MFS_1
465 amino acids: PaperBLAST, CDD
MOT2_HUMAN / O60669 Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7 from Homo sapiens (Human)
PFams: MFS_1
478 amino acids: PaperBLAST, CDD, SwissProt::O60669
46% identical to
TC 2.A.1.13.6 / O15427 Plasma membrane proton-linked monocarboxylate transporter, MCT4 (SLC16A3). Catalyzes the rapid low affinity plasma membrane transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate from Homo sapiens
PFams: MFS_1
465 amino acids: PaperBLAST, CDD
MOT2_MOUSE / O70451 Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7 from Mus musculus (Mouse)
PFams: MFS_1
484 amino acids: PaperBLAST, CDD, SwissProt::O70451
46% identical to
TC 2.A.1.13.6 / O15427 Plasma membrane proton-linked monocarboxylate transporter, MCT4 (SLC16A3). Catalyzes the rapid low affinity plasma membrane transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate from Homo sapiens
PFams: MFS_1
465 amino acids: PaperBLAST, CDD
MOT2_RAT / Q63344 Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7 from Rattus norvegicus (Rat)
PFams: MFS_1
489 amino acids: PaperBLAST, CDD, SwissProt::Q63344
46% identical to
TC 2.A.1.13.6 / O15427 Plasma membrane proton-linked monocarboxylate transporter, MCT4 (SLC16A3). Catalyzes the rapid low affinity plasma membrane transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate from Homo sapiens
PFams: MFS_1
465 amino acids: PaperBLAST, CDD