Clusters of Characterized Proteins

Clustering the characterized proteins for actP (large subunit of pyruvate transporter (actP-like)) in pyruvate catabolism

Or see other characterized proteins similar to actP

Or see all steps for pyruvate catabolism

Or cluster curated proteins matching a keyword

Definition of actP

• UniProt sequence A0A1N7U9G2: SubName: Full=Acetate permease {ECO:0000313|EMBL:AIB35691.1}; SubName: Full=Actetate permease {ECO:0000313|EMBL:ERH55332.1}; SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:PRW83281.1}; SubName: Full=Cation/acetate symporter {ECO:0000313|EMBL:SFB56078.1};
• UniProt sequence G8AHY6: SubName: Full=Acetate transporter {ECO:0000313|EMBL:CCC96889.1};
• UniProt sequence A0A166PH03: SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:KZN18898.1};
• UniProt sequence A0A165ZRB0: SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:AMZ74981.1};
• Ignore hits to P32705 when looking for 'other' hits (Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP. Acetate/glyoxylate permease, ActP. acetate/glycolate:cation symporter. acetate/glycolate:cation symporter)
• UniProt sequence E4PHQ0: SubName: Full=Sodium: solute symporter family protein {ECO:0000313|EMBL:ADP97015.1};
• Curated sequence GFF346: actP-like component of D-alanine uptake system
• Comment: A group of heterodimeric pyruvate transporters. This is the actP-like large subunit. WCS417:GFF1743 = A0A1N7U9G2, azobra:AZOBR_RS02940 = G8AHY6, pseudo1_N1B4:Pf1N1B4_3673 = A0A166PH03, pseudo6_N2E2:Pf6N2E2_5849 = A0A165ZRB0, and psRCH2:Psest_0347 (GFF346) Closely related to E. coli actP = P32705, so ignore that. Added Marinobacter HP15_1251 (E4PHQ0) because it has a specific phenotype (if mild) and fills the gap. And it is closely related to the D-alanine uptake system , so ignore that.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 552-572 amino acids (not heteromeric)

A0A165ZRB0 Cation acetate symporter
552 amino acids: PaperBLAST, CDD, Compare to cluster

A0A166PH03 Cation acetate symporter
552 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1N7U9G2 Acetate permease; SubName: Full=Actetate permease; SubName: Full=Cation acetate symporter; SubName: Full=Cation/acetate symporter
552 amino acids: PaperBLAST, CDD, Compare to cluster

G8AHY6 Acetate transporter
572 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 588-589 amino acids (1/2 heteromeric)

E4PHQ0 Sodium: solute symporter family protein
588 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_0347 actP-like component of D-alanine uptake system from Pseudomonas stutzeri RCH2
PFams: SSF, SSF
Heteromeric, 589 amino acids: PaperBLAST, CDD, Compare to cluster