Other Characterized Proteins Similar to actP

Finding the characterized proteins for actP (large subunit of pyruvate transporter (actP-like)) in pyruvate catabolism

Or see clustering for step actP

Or see all steps for pyruvate catabolism

Or cluster curated proteins matching a keyword

Definition of actP

• UniProt sequence A0A1N7U9G2: SubName: Full=Acetate permease {ECO:0000313|EMBL:AIB35691.1}; SubName: Full=Actetate permease {ECO:0000313|EMBL:ERH55332.1}; SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:PRW83281.1}; SubName: Full=Cation/acetate symporter {ECO:0000313|EMBL:SFB56078.1};
• UniProt sequence G8AHY6: SubName: Full=Acetate transporter {ECO:0000313|EMBL:CCC96889.1};
• UniProt sequence A0A166PH03: SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:KZN18898.1};
• UniProt sequence A0A165ZRB0: SubName: Full=Cation acetate symporter {ECO:0000313|EMBL:AMZ74981.1};
• Ignore hits to P32705 when looking for 'other' hits (Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP. Acetate/glyoxylate permease, ActP. acetate/glycolate:cation symporter. acetate/glycolate:cation symporter)
• UniProt sequence E4PHQ0: SubName: Full=Sodium: solute symporter family protein {ECO:0000313|EMBL:ADP97015.1};
• Curated sequence GFF346: actP-like component of D-alanine uptake system
• Comment: A group of heterodimeric pyruvate transporters. This is the actP-like large subunit. WCS417:GFF1743 = A0A1N7U9G2, azobra:AZOBR_RS02940 = G8AHY6, pseudo1_N1B4:Pf1N1B4_3673 = A0A166PH03, pseudo6_N2E2:Pf6N2E2_5849 = A0A165ZRB0, and psRCH2:Psest_0347 (GFF346) Closely related to E. coli actP = P32705, so ignore that. Added Marinobacter HP15_1251 (E4PHQ0) because it has a specific phenotype (if mild) and fills the gap. And it is closely related to the D-alanine uptake system , so ignore that.

Fetched 6 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 7 other characterized sequences. (Found 8 hits including self hits.)

Removing ignored items reduces this to 6 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for actP.)

TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
PFams: SSF
578 amino acids: PaperBLAST, CDD, TCDB::D5APM1
66% identical to

A0A165ZRB0 Cation acetate symporter
552 amino acids: PaperBLAST, CDD

TC 2.A.21.7.4 / D5AU53 Acetate uptake permease, ActP1; also takes up tellurite from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
PFams: SSF
551 amino acids: PaperBLAST, CDD, TCDB::D5AU53
65% identical to

A0A1N7U9G2 Acetate permease; SubName: Full=Actetate permease; SubName: Full=Cation acetate symporter; SubName: Full=Cation/acetate symporter
552 amino acids: PaperBLAST, CDD

TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida
PFams: SSF
520 amino acids: PaperBLAST, CDD, TCDB::O50471
68% identical to

A0A1N7U9G2 Acetate permease; SubName: Full=Actetate permease; SubName: Full=Cation acetate symporter; SubName: Full=Cation/acetate symporter
552 amino acids: PaperBLAST, CDD

Sama_1523 actP-like component of lactate uptake system from Shewanella amazonensis SB2B
PFams: SSF, SSF
Heteromeric, 572 amino acids: PaperBLAST, CDD, reanno::SB2B:6937353
57% identical to

E4PHQ0 Sodium: solute symporter family protein
588 amino acids: PaperBLAST, CDD

Shew_2371 actP-like component of L-lactate and L-malate uptake system from Shewanella loihica PV-4
PFams: SSF, SSF
Heteromeric, 572 amino acids: PaperBLAST, CDD, reanno::PV4:5209923
57% identical to

E4PHQ0 Sodium: solute symporter family protein
588 amino acids: PaperBLAST, CDD

MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum
PFams: SSF
551 amino acids: PaperBLAST, CDD, SwissProt::Q8NS49
44% identical to

A0A165ZRB0 Cation acetate symporter
552 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for actP.)

b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655
P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli
PFams: SSF
549 amino acids: PaperBLAST, CDD, SwissProt::P32705
79% identical to

A0A166PH03 Cation acetate symporter
552 amino acids: PaperBLAST, CDD