Clusters of Characterized Proteins

Clustering the characterized proteins for cstA (large subunit of pyruvate transporter (CstA)) in pyruvate catabolism

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Definition of cstA

• UniProt sequence A0A0C4Y7X7: SubName: Full=Carbon starvation protein A {ECO:0000313|EMBL:AJG21527.1};
• Curated sequence P15078: Peptide transporter CstA; Carbon starvation protein A. carbon starvation protein A
• Curated sequence P39396: Pyruvate/proton symporter BtsT; Brenztraubensaure transporter; Pyruvate/H(+) symporter. pyruvate:H⁺ symporter. pyruvate:H⁺ symporter
• UniProt sequence A0A0N9VZ52: SubName: Full=Carbon starvation protein A {ECO:0000313|EMBL:ALI04206.1};
• Ignore hits to Q0P9Y2 when looking for 'other' hits (Peptide transporter CstA; Carbon starvation protein A. CstA of 703 aas and 18 putative TMSs. In C. jejuni, this protein plays a role in starvation responses and peptide uptake.  A ΔcstA mutant has reduced use of di- and tri-peptides when used as nitrogen sources. The mutant also has reduced motility and agglutination and shows decreased host-pathogen relationships)
• Comment: E. coli cstA (P15078) was originally thought to be a peptide transporter, but is involved in pyruvate transport along with ybdD (PMID:29358499). The related protein btsT (P39396, formerly yjiY) is also a pyruvate transporter. And a similar protein from Cupriavidus basilensis, RR42_RS20515 = A0A0C4Y7X7, is important for pyruvate utilization. As is AO353_25255 (A0A0N9VZ52) from Pseudomonas fluorescens FW300-N2E3. CstA and RR42_RS20515 seem to operate together with ybdD or similar proteins, but purified BtsT is reported to transport pyruvate (PMID:29061664), so it may not require a ybdD-like component. It is not clear if AO353_25255 functions with a ybdD-like component: the downstream gene, AO353_25260, is ybdD-like and has subtle defects during growth on pyruvate. Q0P9Y2 (CSTA_CAMJE) was proposed to be a peptide transporter in Campylobacter jejuni, but is suspiciously similar to pyruvate transporters, so is ignored.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 685-716 amino acids (not heteromeric)

b0598 carbon starvation protein A from Escherichia coli K-12 substr. MG1655
CSTA_ECOLI / P15078 Peptide transporter CstA; Carbon starvation protein A from Escherichia coli (strain K12)
PFams: CstA, CstA_5TM
701 amino acids: PaperBLAST, CDD, Compare to cluster

b4354 pyruvate:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P39396 pyruvate:H⁺ symporter from Escherichia coli (strain K12)
BTST_ECOLI / P39396 Pyruvate/proton symporter BtsT; Brenztraubensaure transporter; Pyruvate/H(+) symporter from Escherichia coli (strain K12)
PFams: CstA, CstA_5TM
716 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0C4Y7X7 Carbon starvation protein A
690 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0N9VZ52 Carbon starvation protein A
685 amino acids: PaperBLAST, CDD, Compare to cluster