Other Characterized Proteins Similar to cstA

Finding the characterized proteins for cstA (large subunit of pyruvate transporter (CstA)) in pyruvate catabolism

Or see clustering for step cstA

Or see all steps for pyruvate catabolism

Or cluster curated proteins matching a keyword

Definition of cstA

• UniProt sequence A0A0C4Y7X7: SubName: Full=Carbon starvation protein A {ECO:0000313|EMBL:AJG21527.1};
• Curated sequence P15078: Peptide transporter CstA; Carbon starvation protein A. carbon starvation protein A
• Curated sequence P39396: Pyruvate/proton symporter BtsT; Brenztraubensaure transporter; Pyruvate/H(+) symporter. pyruvate:H⁺ symporter. pyruvate:H⁺ symporter
• UniProt sequence A0A0N9VZ52: SubName: Full=Carbon starvation protein A {ECO:0000313|EMBL:ALI04206.1};
• Ignore hits to Q0P9Y2 when looking for 'other' hits (Peptide transporter CstA; Carbon starvation protein A. CstA of 703 aas and 18 putative TMSs. In C. jejuni, this protein plays a role in starvation responses and peptide uptake.  A ΔcstA mutant has reduced use of di- and tri-peptides when used as nitrogen sources. The mutant also has reduced motility and agglutination and shows decreased host-pathogen relationships)
• Comment: E. coli cstA (P15078) was originally thought to be a peptide transporter, but is involved in pyruvate transport along with ybdD (PMID:29358499). The related protein btsT (P39396, formerly yjiY) is also a pyruvate transporter. And a similar protein from Cupriavidus basilensis, RR42_RS20515 = A0A0C4Y7X7, is important for pyruvate utilization. As is AO353_25255 (A0A0N9VZ52) from Pseudomonas fluorescens FW300-N2E3. CstA and RR42_RS20515 seem to operate together with ybdD or similar proteins, but purified BtsT is reported to transport pyruvate (PMID:29061664), so it may not require a ybdD-like component. It is not clear if AO353_25255 functions with a ybdD-like component: the downstream gene, AO353_25260, is ybdD-like and has subtle defects during growth on pyruvate. Q0P9Y2 (CSTA_CAMJE) was proposed to be a peptide transporter in Campylobacter jejuni, but is suspiciously similar to pyruvate transporters, so is ignored.

Fetched 4 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 3 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for cstA.)

CSTA_CAMJE / Q0P9Y2 Peptide transporter CstA; Carbon starvation protein A from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
TC 2.A.114.1.5 / Q0P9Y2 CstA of 703 aas and 18 putative TMSs. In C. jejuni, this protein plays a role in starvation responses and peptide uptake.  A ΔcstA mutant has reduced use of di- and tri-peptides when used as nitrogen sources. The mutant also has reduced motility and agglutination and shows decreased host-pathogen relationships from Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
PFams: CstA, CstA_5TM
703 amino acids: PaperBLAST, CDD, SwissProt::Q0P9Y2
56% identical to

b0598 carbon starvation protein A from Escherichia coli K-12 substr. MG1655
CSTA_ECOLI / P15078 Peptide transporter CstA; Carbon starvation protein A from Escherichia coli (strain K12)
PFams: CstA, CstA_5TM
701 amino acids: PaperBLAST, CDD