Other Characterized Proteins Similar to mtlA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to mtlA

Finding the characterized proteins for mtlA (PTS system for polyols, EII-CBA components) in D-sorbitol (glucitol) catabolism

Or see clustering for step mtlA

Or see all steps for D-sorbitol (glucitol) catabolism

Or cluster curated proteins matching a keyword

Definition of mtlA

Curated sequence P00550: protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197). PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197. Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex. mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198). mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198)
Curated sequence Q9KKQ7: The mannitol/glucitol transporter, MtlA (IICBAMtl)
Ignore hits to P42956 when looking for 'other' hits (PTS system, mannitol-specific IICBA component aka EIICBA-Mtl aka Mannitol-permease IIABC component aka Phosphotransferase enzyme II, CBA component aka EC 2.7.1.69 aka EII-Mtl, component of The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF)
Comment: polyol PTS system with EII-CBA all fused, known as mtlA in E. coli (TC 4.A.2.1.2). Also includes TC 4.A.2.1.12 (Q9KKQ7). TC 4.A.2.1.5 (P42956) is the B. subtilis mannitol transporter but probably has weak activity no sorbitol (PMC222339). so exclude it. Not known if the homologs from Geobacillus stearothermophilus (P50852) or Clostridium acetobutylicum (O65989) [which lack the A component], which are mannitol transporters, are capable of sorbitol transport

Fetched 2 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 5 other characterized sequences. (Found 7 hits including self hits.)

Removing ignored items reduces this to 4 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for mtlA.)

PTMCB_GEOSE / P50852 PTS system mannitol-specific EIICB component; EIICB-Mtl; EII-Mtl; EC 2.7.1.197 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
PFams: PTS_EIIC, PTS_IIB
471 amino acids: PaperBLAST, CDD, SwissProt::P50852
64% identical to

b3599 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli K-12 substr. MG1655
P00550 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli (strain K12)
PTM3C_ECOLI / P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12)
P00550 protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197) from Escherichia coli
TC 4.A.2.1.2 / P00550 Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex from Escherichia coli
GB|AAC76623.1 PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12
PFams: PTS_EIIC, PTS_IIB, PTS_EIIA_2
637 amino acids: PaperBLAST, CDD

PTMCB_CLOAB / O65989 PTS system mannitol-specific EIICB component; EIICB-Mtl; EII-Mtl; EC 2.7.1.197 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
PFams: PTS_EIIC, PTS_IIB
481 amino acids: PaperBLAST, CDD, SwissProt::O65989
56% identical to

b2933 mannitol-specific PTS enzyme IICB component CmtA (EC 2.7.1.197) from Escherichia coli K-12 substr. MG1655
P69826 mannitol-specific PTS enzyme IICB component CmtA (EC 2.7.1.197) from Escherichia coli (strain K12)
PTMCB_ECOLI / P69826 PTS system mannitol-specific cryptic EIICB component; EIICB-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12)
RF|NP_417408 EIICB-Mtl from Escherichia coli K12
PFams: PTS_EIIC, PTS_IIB
Heteromeric, 462 amino acids: PaperBLAST, CDD, SwissProt::P69826
52% identical to

PTMCB_STACA / P28008 PTS system mannitol-specific EIICB component; EIICB-Mtl; EII-Mtl; EC 2.7.1.197 from Staphylococcus carnosus
PFams: PTS_EIIC, PTS_IIB
518 amino acids: PaperBLAST, CDD, SwissProt::P28008
50% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for mtlA.)

TC 4.A.2.1.5 / P42956 PTS system, mannitol-specific IICBA component aka EIICBA-Mtl aka Mannitol-permease IIABC component aka Phosphotransferase enzyme II, CBA component aka EC 2.7.1.69 aka EII-Mtl, component of The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF from Bacillus subtilis
PFams: PTS_EIIC, PTS_IIB
Heteromeric, 478 amino acids: PaperBLAST, CDD, TCDB::P42956
63% identical to