Clusters of Characterized Proteins

Clustering the characterized proteins for manZ (glucose PTS, enzyme EIID) in sucrose catabolism

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Definition of manZ

• Curated sequence P69805: PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component. mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193)
• Curated sequence E1UCI2: PTS system, mannose/fructose/sorbose family, IID component, component of The primary glucose /mannose uptake transporter, ManLMN
• Curated sequence P69805: PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose
• Curated sequence Q04GJ9: PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system
• Curated sequence Q2QKM2: ManN aka EIID, component of Glucose porter, ManLMN
• Curated sequence Q5M5W8: ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
• Ignore hits to Q5IRC0 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
• Ignore hits to D2BKY9 when looking for 'other' hits (Mannose-specific PTS system, IID component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine)
• Comment: (The E. coli entry, P69805, is listed twice, because the sequence in TCDB has 3 extra N-terminal residues.) Also similar is Lmo0781 (TC 4.A.6.1.16 / Q8Y8W1) from MpoABCD; should perhaps be ignored.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Escherichia coli

b1819 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655
P69805 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli (strain K12)
PTND_ECOLI / P69805 PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component from Escherichia coli (strain K12)
PFams: EIID-AGA
Heteromeric, 283 amino acids: PaperBLAST, CDD (Cluster 1)

TC 4.A.6.1.1 / P69805 PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
PFams: EIID-AGA
Heteromeric, 286 amino acids: PaperBLAST, CDD (Cluster 1)

Lactobacillus casei

TC 4.A.6.1.6 / Q2QKM2 ManN aka EIID, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD (Cluster 1)

Listeria monocytogenes

TC 4.A.6.1.15 / E1UCI2 PTS system, mannose/fructose/sorbose family, IID component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD (Cluster 1)

Oenococcus oeni

TC 4.A.6.1.10 / Q04GJ9 PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIID-AGA
Heteromeric, 304 amino acids: PaperBLAST, CDD (Cluster 1)

Streptococcus thermophilus

TC 4.A.6.1.7 / Q5M5W8 ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD (Cluster 1)