Clusters of Characterized Proteins

Clustering the characterized proteins for thuK (sucrose ABC transporter, ATPase component ThuK) in sucrose catabolism

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Definition of thuK

• Curated sequence Q72L52: Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose
• Curated sequence Q9R9Q4: ThuK aka RB0314 aka SMB20328, component of Trehalose/maltose/sucrose porter (trehalose inducible). ABC transporter for D-Trehalose, ATPase component
• Ignore hits to SMc03065 when looking for 'other' hits (ABC transporter for D-Maltose and D-Trehalose, ATPase component. AglK aka R00699 aka SMC03065, component of Sucrose/maltose/trehalose porter (sucrose-inducible))
• UniProt sequence A0A166QFW2: SubName: Full=ABC transporter {ECO:0000313|EMBL:KZN20193.1};
• Comment: aglK (Q9Z3R9, SMc03065) also clustered with thuK but is not that similar (56% identity) so is marked ignore

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 342-381 amino acids (2/3 heteromeric)

TC 3.A.1.1.24 / TC 3.A.1.1.25 / Q72L52 Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
PFams: ABC_tran, OB_MalK, TOBE_2, TOBE
Heteromeric, 376 amino acids: PaperBLAST, CDD, Compare to cluster

SM_b20328 ABC transporter for D-Trehalose, ATPase component from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q4 ThuK aka RB0314 aka SMB20328, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti)
PFams: ABC_tran, TOBE_2, TOBE
Heteromeric, 342 amino acids: PaperBLAST, CDD, Compare to cluster

A0A166QFW2 ABC transporter
381 amino acids: PaperBLAST, CDD, Compare to cluster